Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2202756..2203411 Replicon chromosome
Accession NZ_CP013391
Organism Burkholderia contaminans strain FL-1-2-30-S1-D0

Toxin (Protein)


Gene name vapC Uniprot ID A0A4R4BYV1
Locus tag WI95_RS27205 Protein ID WP_046548294.1
Coordinates 2202756..2203175 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A4R4C038
Locus tag WI95_RS27210 Protein ID WP_046548594.1
Coordinates 2203172..2203411 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WI95_RS27180 2198161..2198955 + 795 WP_047849668.1 AraC family transcriptional regulator -
WI95_RS27185 2199142..2200119 + 978 WP_122476337.1 DMT family transporter -
WI95_RS27190 2200328..2200876 + 549 WP_122476339.1 permease -
WI95_RS27195 2200976..2201110 - 135 WP_006485835.1 entericidin A/B family lipoprotein -
WI95_RS27200 2201344..2202639 + 1296 WP_039360985.1 aspartate carbamoyltransferase -
WI95_RS27205 2202756..2203175 - 420 WP_046548294.1 type II toxin-antitoxin system VapC family toxin Toxin
WI95_RS27210 2203172..2203411 - 240 WP_046548594.1 Arc family DNA-binding protein Antitoxin
WI95_RS27215 2203723..2205966 + 2244 WP_122477470.1 TonB-dependent siderophore receptor -
WI95_RS27220 2205970..2206749 + 780 WP_122476341.1 sel1 repeat family protein -
WI95_RS27225 2206746..2207429 + 684 WP_122476343.1 Fe2+-dependent dioxygenase -
WI95_RS27230 2207527..2207766 + 240 WP_010089452.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
WI95_RS27235 2207763..2208158 + 396 WP_047851020.1 type II toxin-antitoxin system VapC family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15151.41 Da        Isoelectric Point: 5.7471

>T58583 WP_046548294.1 NZ_CP013391:c2203175-2202756 [Burkholderia contaminans]
MILVDTNVMSEPLRREPSAAVIEWLDAQNVETLFLAAISLGEMRFGVAALPEGRRRDWLHHSIEQRVVPLFRGRILPFDD
AASKAYASIRARARASGSTIAPADVFIAATAEANGLIIATRDVAPFEAVGLRVIDPWAS

Download         Length: 420 bp

>T58583 NZ_CP013391:c2203175-2202756 [Burkholderia contaminans]
ATGATCCTTGTTGATACGAACGTGATGTCCGAGCCGCTGCGGCGTGAGCCGAGCGCGGCCGTGATCGAGTGGCTCGATGC
CCAGAACGTCGAAACGTTGTTTCTTGCTGCGATCAGTCTTGGCGAAATGCGCTTCGGCGTGGCGGCGCTCCCGGAAGGGC
GCAGGCGCGACTGGCTTCACCACAGCATCGAGCAACGCGTCGTGCCGCTGTTTCGCGGCAGGATTCTGCCGTTCGACGAT
GCGGCGAGCAAAGCGTATGCGAGCATTCGAGCGCGTGCGCGTGCCTCGGGCAGTACGATCGCGCCTGCAGATGTCTTTAT
TGCCGCGACGGCCGAGGCGAACGGATTGATCATTGCGACGCGCGACGTTGCGCCATTCGAGGCTGTCGGCCTGCGGGTGA
TTGATCCATGGGCGTCGTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8776.06 Da        Isoelectric Point: 6.4684

>AT58583 WP_046548594.1 NZ_CP013391:c2203411-2203172 [Burkholderia contaminans]
MPVITVRNLPDEVHRALRIRAAQHGRSTEAEVRDILEQAVLPGGRLKLGTLLAEIGREAGGVEFDVRRDKTLTDPMSFE

Download         Length: 240 bp

>AT58583 NZ_CP013391:c2203411-2203172 [Burkholderia contaminans]
ATGCCCGTGATTACTGTTCGAAATTTGCCCGATGAAGTGCACCGCGCGCTCCGAATTCGTGCGGCGCAGCATGGGCGTAG
CACTGAAGCCGAGGTGCGTGACATCCTGGAGCAGGCCGTTCTGCCGGGCGGCCGGCTGAAGCTGGGAACGCTGCTGGCTG
AAATCGGACGGGAGGCGGGCGGCGTCGAATTCGACGTTCGGCGCGACAAGACGCTAACCGACCCGATGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4R4BYV1

Antitoxin

Source ID Structure
AlphaFold DB A0A4R4C038

References