Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2089481..2091231 Replicon chromosome
Accession NZ_CP013391
Organism Burkholderia contaminans strain FL-1-2-30-S1-D0

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag WI95_RS26620 Protein ID WP_122476247.1
Coordinates 2090335..2091231 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4R4BXQ4
Locus tag WI95_RS26615 Protein ID WP_047849731.1
Coordinates 2089481..2090338 (-) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WI95_RS26595 2084644..2086134 - 1491 WP_122476243.1 aldehyde dehydrogenase -
WI95_RS26600 2086207..2087034 - 828 WP_046548144.1 aspartate dehydrogenase -
WI95_RS26605 2087027..2088694 - 1668 WP_046548145.1 thiamine pyrophosphate-binding protein -
WI95_RS26610 2088687..2089484 - 798 WP_122476245.1 SDR family oxidoreductase -
WI95_RS26615 2089481..2090338 - 858 WP_047849731.1 IclR family transcriptional regulator Antitoxin
WI95_RS26620 2090335..2091231 - 897 WP_122476247.1 alpha/beta fold hydrolase Toxin
WI95_RS26625 2091250..2091777 - 528 WP_039344094.1 cupin domain-containing protein -
WI95_RS26630 2091815..2092585 - 771 WP_046548149.1 SDR family oxidoreductase -
WI95_RS26635 2092578..2093654 - 1077 WP_122476249.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
WI95_RS26640 2093707..2094018 - 312 WP_047849728.1 hypothetical protein -
WI95_RS26645 2094020..2094337 - 318 WP_011354710.1 non-heme iron oxygenase ferredoxin subunit -
WI95_RS26650 2094782..2095861 + 1080 WP_122476251.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, N-terminal

(24-72)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30777.10 Da        Isoelectric Point: 8.3561

>T58582 WP_122476247.1 NZ_CP013391:c2091231-2090335 [Burkholderia contaminans]
MSVIDKRERDRTAAFAALLGQFPERRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAATDYAASLNAWLEALGIERCVLVGHSLGAIIAGGLIRVMPARIAGLLLMSPAGGYGSAPAETR
DARRDARLAMLAELGPAGLAEQRSGNMLSGFANEDARAWVRWNMARIVPAGYAQATHLLANADLATDLAGFRGRTAVAVG
ANDAITPPAACERVAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDTFCRQCDQQRGLA

Download         Length: 897 bp

>T58582 NZ_CP013391:c2091231-2090335 [Burkholderia contaminans]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTCCCCGAACGGCGTTG
CGCGGCCGGCGCTGCGGGCACGATCGGATATCGCGAGGCCGGCGCGCAGCATGCGGGCCGTGCGTTGCCCGTCGTGCTGC
TGCACGGCATCGGCTCGGGCGCCGCATCGTGGGTGCGCCAGCTCGACACGCTCGGCGCATCGCGGCGCGTGCTCGCGTGG
GATGCGCCCGGTTACGGCGTGTCGACGCCGGTGCACGGCGCGTCGCCGGCCGCCACCGATTACGCGGCGTCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGTCATTCGCTCGGCGCGATCATCGCGGGTGGTCTCATCC
GCGTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGATGTCGCCCGCGGGCGGCTACGGCAGCGCACCGGCCGAAACGCGC
GACGCGCGCCGCGACGCGCGGCTCGCGATGCTCGCCGAACTCGGCCCGGCCGGGCTCGCCGAGCAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGAACGAGGATGCGCGTGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTATGCGC
AGGCCACGCATCTGCTGGCGAACGCCGATCTCGCAACGGATCTCGCGGGCTTTCGCGGCCGGACGGCCGTGGCCGTCGGC
GCGAATGACGCGATCACGCCGCCCGCCGCGTGCGAGCGCGTCGCCGCGGCCGCGCACGTCGGGCTGCAGGTGATTCCGCA
GGCAGGCCATGCCGGCTACGTGGAAGCACCGGCCGTTTATTCCGCACTGATCGACACGTTCTGCCGTCAGTGCGACCAAC
AGCGGGGACTGGCATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31404.94 Da        Isoelectric Point: 6.5061

>AT58582 WP_047849731.1 NZ_CP013391:c2090338-2089481 [Burkholderia contaminans]
MNEPLQQPELENGKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGALNRMTNATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQRIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT58582 NZ_CP013391:c2090338-2089481 [Burkholderia contaminans]
ATGAACGAACCGCTGCAACAACCCGAACTCGAAAACGGCAAGGCCGAAGCCAGCTACGTGGTGCCTGGCCTCGAACGCGG
GCTGCGGATTCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGCGCGCCCGAATTGTCGAAGCGGCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTCCTCGAGCGCGCGGACAAGGATCGCAACTACAAG
CTCGGCATTGCCGTGCTGCGGCTCGGTTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCCGTGATCGA
AAGCCTGCGCGATGCGACCGGCTTCACGACGCACATCGTGATCCGTGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGGCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGCACGCGCTTGCCCGCGCATGCGACGACGCACGGTCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAACTGCATGCGCTATATCCGGAAGGCGCGCTGAACCGGATGACGAACGCGAC
GCCGGAAACGGTCGACGCGCTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGCATCTCGGTGGTCACCGCGCCGGTGCGTAACGAGACGCAGAGGATCGTTGCGTGCATCACGGTGACGGTGCCG
AGGCCGGAAATTGACGCGGCGCTGATCGCGGACGGCCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTTTGAAGGCTTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4R4BXQ4

References