Detailed information of TA system TA058580

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 2704696..2705378
• Replicon: chromosome
• Accession: NZ_CP013390
• Organism: Burkholderia contaminans strain FL-1-2-30-S1-D0

Toxin (Protein)

• Gene name: tad
• Uniprot ID: A0A6P2YP52
• Locus tag: WI95_RS12865
• Protein ID: WP_046544690.1
• Coordinates: 2704696..2705058 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: WI95_RS12870
• Protein ID: WP_046544689.1
• Coordinates: 2705055..2705378 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WI95_RS12840	2700525..2700980	+	456	WP_046544694.1	VOC family protein	-
WI95_RS12845	2701048..2702598	-	1551	WP_046544693.1	sodium:solute symporter family protein	-
WI95_RS12850	2702595..2702837	-	243	WP_011352801.1	DUF3311 domain-containing protein	-
WI95_RS12855	2703036..2703953	-	918	WP_046544691.1	spermidine synthase	-
WI95_RS12860	2704098..2704352	+	255	WP_047852431.1	hypothetical protein	-
WI95_RS12865	2704696..2705058	+	363	WP_046544690.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
WI95_RS12870	2705055..2705378	+	324	WP_046544689.1	helix-turn-helix domain-containing protein	Antitoxin
WI95_RS12875	2705433..2705909	-	477	WP_122474219.1	DNA-deoxyinosine glycosylase	-
WI95_RS12880	2705909..2706505	-	597	WP_089484450.1	chorismate lyase	-
WI95_RS12885	2706514..2708412	-	1899	WP_046544687.1	molecular chaperone HtpG	-
WI95_RS12890	2708572..2710032	-	1461	WP_039370360.1	PLP-dependent aminotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13299.24 Da
• Isoelectric Point: 9.9311

>T58580 WP_046544690.1 NZ_CP013390:2704696-2705058 [Burkholderia contaminans]
MDPYIKPLYWLGSARKDLKAMPQAVQDTFGYALYLAQTGRKHDQAKPLKGFGSAGVLEIVESEDNGTYRAVYTVKLGSSV
YVLHCFQKKSSIGIATPRPDSDLVRERLKAAEAHAQGVRR

Nucleotide

• Length: 363 bp

>T58580 NZ_CP013390:2704696-2705058 [Burkholderia contaminans]
ATGGATCCATACATCAAACCGCTGTACTGGCTCGGCTCAGCGCGCAAGGATTTGAAAGCGATGCCGCAAGCCGTGCAGGA
CACGTTCGGCTATGCGCTGTATCTGGCGCAGACGGGACGCAAGCACGATCAGGCCAAGCCGTTGAAAGGATTCGGCTCGG
CCGGCGTGCTCGAGATCGTTGAATCGGAAGACAACGGCACGTATCGCGCGGTCTATACGGTGAAGCTCGGCAGCAGCGTG
TACGTGCTGCACTGTTTCCAGAAGAAGTCGTCGATCGGTATCGCAACACCGAGGCCGGACAGCGATCTCGTCCGCGAACG
TCTGAAAGCGGCCGAAGCACACGCACAAGGAGTAAGGCGATGA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11806.68 Da
• Isoelectric Point: 7.3600

>AT58580 WP_046544689.1 NZ_CP013390:2705055-2705378 [Burkholderia contaminans]
MIEIEQGSGNVYADLGMHDAAEMRVKAQLAAKIAEIIKARQWTQQHAARLLGITQPKLSNMLRGQFRGVSETKMLECLAK
LGRDVHIVVGPDRQSEVEGHIEVVFAA

Nucleotide

• Length: 324 bp

>AT58580 NZ_CP013390:2705055-2705378 [Burkholderia contaminans]
ATGATCGAAATCGAACAGGGCAGCGGCAACGTCTACGCCGATCTCGGCATGCACGATGCCGCCGAAATGCGGGTGAAAGC
CCAACTCGCCGCGAAGATCGCGGAAATCATCAAGGCGCGCCAATGGACACAGCAGCACGCGGCCCGGTTGCTCGGCATCA
CGCAGCCGAAGCTGTCGAACATGCTGCGCGGGCAGTTTCGCGGCGTCAGCGAAACGAAGATGCTCGAATGTCTGGCGAAG
CTCGGACGCGACGTGCACATCGTCGTCGGGCCCGATCGTCAATCGGAAGTCGAAGGGCACATCGAGGTCGTCTTCGCAGC
GTGA

Structures

Toxin

• AlphaFold DB: A0A6P2YP52