Detailed information of TA system TA058579

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 1786258..1786937
• Replicon: chromosome
• Accession: NZ_CP013390
• Organism: Burkholderia contaminans strain FL-1-2-30-S1-D0

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: WI95_RS08355
• Protein ID: WP_122473906.1
• Coordinates: 1786521..1786937 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A4R4C8B3
• Locus tag: WI95_RS08350
• Protein ID: WP_047850906.1
• Coordinates: 1786258..1786524 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WI95_RS08335	1781805..1784066	+	2262	WP_122473905.1	TonB-dependent siderophore receptor	-
WI95_RS08340	1784153..1784992	+	840	WP_046545684.1	N(5)-hydroxyornithine transformylase PvdF	-
WI95_RS08345	1784992..1786008	+	1017	WP_046545685.1	acetyltransferase	-
WI95_RS08350	1786258..1786524	+	267	WP_047850906.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
WI95_RS08355	1786521..1786937	+	417	WP_122473906.1	PIN domain-containing protein	Toxin
WI95_RS08360	1786986..1787891	-	906	WP_047850905.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
WI95_RS08365	1787860..1788930	-	1071	WP_046545688.1	hypothetical protein	-
WI95_RS08370	1789273..1790436	+	1164	WP_046545689.1	amidohydrolase	-
WI95_RS08375	1790462..1790629	+	168	WP_122473907.1	type II toxin-antitoxin system RelE/ParE family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-130)

Antitoxin

• SpoVT-AbrB domain (7-55)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 14684.78 Da
• Isoelectric Point: 7.3233

>T58579 WP_122473906.1 NZ_CP013390:1786521-1786937 [Burkholderia contaminans]
VTTLYMLDTNICSFIMRERPPVVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGRKASPKHAELVTAFVSRLDGVLSWDTA
AVDATAAIRADFASRGTPIGTNDASIAGHAIAAGAVLVTHDSREFGRVAGLTLEDWAA

Nucleotide

• Length: 417 bp

>T58579 NZ_CP013390:1786521-1786937 [Burkholderia contaminans]
GTGACCACGCTCTACATGCTCGATACGAACATCTGTTCGTTCATCATGCGCGAGCGGCCGCCCGTGGTGCTGTCCCGGTT
GCAGTCGTGCGTCAATGCGCAGCACCGGATCGTCGTCTCGGCAATTACCTATGCCGAAATGCGATTCGGCGCGGTCGGCA
GGAAGGCATCGCCGAAGCATGCGGAACTCGTGACGGCCTTTGTTTCGCGACTGGATGGCGTGCTGTCGTGGGACACGGCG
GCCGTCGACGCAACGGCCGCGATTCGTGCGGATTTCGCCTCGCGCGGCACGCCGATCGGCACCAACGACGCATCGATCGC
GGGCCATGCGATTGCGGCCGGTGCGGTGCTCGTCACCCACGACAGCCGCGAGTTCGGCCGTGTCGCCGGGTTGACGCTCG
AAGACTGGGCGGCCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9728.94 Da
• Isoelectric Point: 4.4819

>AT58579 WP_047850906.1 NZ_CP013390:1786258-1786524 [Burkholderia contaminans]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWLSFASEPPADADFLAERPSVIEPGRFDLSDGGG
AAPTESGQ

Nucleotide

• Length: 267 bp

>AT58579 NZ_CP013390:1786258-1786524 [Burkholderia contaminans]
ATGCGCACCGTTTCCATTTTCAAGAACGCCCGTAACCAGGCAATCCGCATCCCGAAGGACATGGAGTTCGAGGGGGTGAC
CGAACTCGAGATTCGCCGCGAGGGCGACACACTGCTGCTGCGGCCGGTGCGGCCCACATGGCTCTCGTTCGCGAGCGAAC
CGCCGGCCGACGCCGACTTCCTTGCCGAACGCCCGTCCGTCATCGAGCCCGGCCGCTTCGACCTGTCCGACGGTGGCGGC
GCCGCACCGACGGAGTCCGGCCAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A4R4C8B3