Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1527353..1529100 Replicon chromosome
Accession NZ_CP013388
Organism Burkholderia sp. BDU8

Toxin (Protein)


Gene name doc Uniprot ID A0A1B4FTR1
Locus tag WS71_RS07235 Protein ID WP_066496237.1
Coordinates 1527353..1528249 (+) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1B4FTL6
Locus tag WS71_RS07240 Protein ID WP_066496239.1
Coordinates 1528246..1529100 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WS71_RS07200 1522754..1523842 - 1089 WP_066496220.1 porin -
WS71_RS07210 1524278..1524595 + 318 WP_066496223.1 non-heme iron oxygenase ferredoxin subunit -
WS71_RS07215 1524597..1524908 + 312 WP_066496225.1 hypothetical protein -
WS71_RS07220 1524943..1526010 + 1068 WP_066496233.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
WS71_RS07225 1526007..1526777 + 771 WP_066496235.1 SDR family oxidoreductase -
WS71_RS07230 1526809..1527336 + 528 WP_066496563.1 cupin domain-containing protein -
WS71_RS07235 1527353..1528249 + 897 WP_066496237.1 alpha/beta fold hydrolase Toxin
WS71_RS07240 1528246..1529100 + 855 WP_066496239.1 IclR family transcriptional regulator Antitoxin
WS71_RS07245 1529097..1529894 + 798 WP_066496243.1 SDR family oxidoreductase -
WS71_RS07250 1529887..1531560 + 1674 WP_066496244.1 thiamine pyrophosphate-binding protein -
WS71_RS07255 1531553..1532368 + 816 WP_066496247.1 aspartate dehydrogenase -
WS71_RS07260 1532409..1533899 + 1491 WP_066496248.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-280)

Antitoxin

Transcription regulator IclR, C-terminal

(143-265)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30538.57 Da        Isoelectric Point: 7.7316

>T58574 WP_066496237.1 NZ_CP013388:1527353-1528249 [Burkholderia sp. BDU8]
MSAIPTTMNDAGATPFAELLEHFPERRAAAGATGTIGYREAGGVRGERCPVVLLHGIGSGAASWVRQLDALGATRRALAW
DAPGYGASSRVAAESPVAADYAASLGAWLDALRIERCVLVGHSLGAIVAGAFARAAGERLSGLLLISPAGGYGSAAADVR
AERRDSRLALLASLGPQGLAEQRSASMLSAHASDAARAWVRWNMARIVPAGYAQATHLLANADLAADLAHYRGRVAVAVG
ADDAITPPAACERIAQAARVGLQVIPRAGHAGYVEAPDAYGALIDAFCRQCDGQRGAA

Download         Length: 897 bp

>T58574 NZ_CP013388:1527353-1528249 [Burkholderia sp. BDU8]
ATGAGCGCGATTCCCACGACGATGAACGACGCCGGCGCGACGCCGTTCGCCGAACTGCTCGAGCATTTTCCCGAGCGGCG
CGCGGCGGCGGGTGCCACAGGCACGATCGGCTACCGGGAGGCCGGCGGCGTGCGCGGCGAGCGCTGTCCCGTCGTGCTGT
TGCACGGCATCGGATCGGGCGCGGCGTCGTGGGTGCGGCAGCTCGATGCGCTCGGCGCGACGCGCCGCGCGCTCGCGTGG
GACGCGCCCGGCTACGGCGCGTCGTCGCGCGTCGCCGCCGAGTCGCCTGTCGCGGCCGATTACGCGGCGTCGCTCGGCGC
ATGGCTCGACGCGCTGCGAATCGAGCGCTGCGTGCTCGTCGGCCATTCGCTCGGCGCGATCGTCGCCGGCGCGTTCGCGC
GCGCCGCGGGCGAGCGTCTTTCAGGATTGCTGTTGATTTCTCCCGCGGGCGGTTATGGCAGCGCGGCCGCCGACGTGCGG
GCCGAGCGGCGCGACAGCCGTCTCGCGCTGCTCGCGTCGCTCGGCCCGCAAGGGCTCGCCGAGCAGCGCAGCGCGAGCAT
GCTGTCCGCGCATGCGAGCGACGCGGCGCGTGCGTGGGTGCGCTGGAACATGGCGCGGATCGTGCCCGCCGGCTATGCGC
AGGCGACGCACCTGCTCGCGAACGCGGATCTCGCGGCCGACCTCGCGCATTACCGCGGCCGCGTGGCGGTCGCGGTCGGC
GCGGACGACGCGATCACGCCGCCCGCCGCATGCGAGCGGATCGCGCAAGCGGCGCGCGTCGGGTTGCAGGTGATCCCGCG
CGCGGGCCACGCGGGCTACGTCGAAGCGCCCGATGCGTATGGCGCGCTGATCGATGCGTTTTGCCGTCAATGCGACGGAC
AGCGAGGTGCGGCATGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 30958.37 Da        Isoelectric Point: 6.9972

>AT58574 WP_066496239.1 NZ_CP013388:1528246-1529100 [Burkholderia sp. BDU8]
MSEPLLKDADDAKNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIEGLRDATGFTTHIVIRDGRDVVFVAKAQNAGHAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAQLRALYPEPALERVTKATPETVDALSGVIREDARRGYGIGNSAFERDISVVTAPVRNDASKIVAVVTVTVPR
PEIDASLVADGLIDKVLRAAAELSRRLNYRSDDENTYLKALGLR

Download         Length: 855 bp

>AT58574 NZ_CP013388:1528246-1529100 [Burkholderia sp. BDU8]
ATGAGCGAACCGCTGCTGAAAGACGCCGACGACGCGAAAAACGATTCGAACTACGTCGTGCCGGGGCTCGAACGCGGTCT
GCGCATTCTTGCCGAGTTCTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAGCTGTCGAAGCGGCTCGGCATTCCGCGCA
CGACGGTGTTCCGTCTGTTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGCGCGGACAAGGACCGCAATTATCGATTG
GGCGTCGCGGTGCTGCGCCTCGGCTTCGAATACCTGAGCTCGCTCGAGCTGACCGATCTCGGCTTGCCGGTGATCGAAGG
GCTGCGCGACGCGACGGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTCGTGTTCGTCGCGAAGGCGCAAA
ACGCGGGGCACGCGTTCGGCTCGGTGCGGGTGAACGTCGGCACGCGCTTGCCCGCGCATGCGACGACGCACGGCCACGTG
CTGATGGGCGACCTGTCGCTCGCTCAGTTGCGCGCGCTGTATCCGGAGCCTGCGCTCGAACGCGTGACGAAGGCGACGCC
CGAGACCGTCGACGCGCTGTCCGGCGTGATCCGCGAAGACGCGCGGCGTGGCTACGGGATCGGCAACTCGGCTTTCGAGC
GCGACATCTCGGTCGTCACGGCGCCCGTGCGCAACGACGCGAGCAAGATCGTCGCGGTCGTCACGGTGACGGTGCCGCGG
CCGGAGATCGACGCGTCGCTCGTCGCCGACGGGCTGATCGACAAGGTGCTGCGCGCGGCGGCGGAGCTGTCGCGGCGGTT
GAATTACCGGTCCGACGACGAAAACACCTATTTGAAGGCATTGGGATTGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4FTR1

Antitoxin

Source ID Structure
AlphaFold DB A0A1B4FTL6

References