Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 867530..869304 Replicon chromosome
Accession NZ_CP013388
Organism Burkholderia sp. BDU8

Toxin (Protein)


Gene name hipA Uniprot ID A0A1B4FSB9
Locus tag WS71_RS04255 Protein ID WP_066492709.1
Coordinates 867530..868879 (-) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1B4FSC5
Locus tag WS71_RS04260 Protein ID WP_066492708.1
Coordinates 868876..869304 (-) Length 143 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WS71_RS36090 863045..863386 + 342 WP_066492821.1 DNA-binding protein -
WS71_RS04230 863995..865398 - 1404 WP_066492713.1 hypothetical protein -
WS71_RS04235 865493..866385 + 893 Protein_785 LysR family transcriptional regulator -
WS71_RS04245 866619..867062 + 444 WP_066492711.1 hypothetical protein -
WS71_RS04250 867171..867459 - 289 Protein_787 haloacid dehalogenase-like hydrolase -
WS71_RS04255 867530..868879 - 1350 WP_066492709.1 type II toxin-antitoxin system HipA family toxin Toxin
WS71_RS04260 868876..869304 - 429 WP_066492708.1 helix-turn-helix domain-containing protein Antitoxin
WS71_RS04270 870276..872678 + 2403 WP_108026432.1 cellulose biosynthesis cyclic di-GMP-binding regulatory protein BcsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(159-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-71)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 49858.78 Da        Isoelectric Point: 9.0380

>T58573 WP_066492709.1 NZ_CP013388:c868879-867530 [Burkholderia sp. BDU8]
VSARRSTRTTRLHLWMNGLPVGYWEHARDGERLVYFDEWIADPQGRPLSLSLPFTPGNQPYRGRLVSDYFDNLLPDSEPI
RRRIAMRYRTGGTSPFALLSTLGRDCVGALQMLPPDETPDDLDRIRGHALADADIARLLREITSAPQAGRHEPLDDLRLS
IAGAQEKTALLRHRGRWLLPEGSTPTTHILKLPLGLVGNRRADMRTSVENEWLCSKIVAAYGLPIAHCDIAHFDDRKALV
VERFDRKPSSDARWLLRLPQEDMCQATGTSAFDKYQADGGPGIETIMDVLAGSEHAADRYAFFAAQIVFWLLAATDGHAK
NFSIAHLPGNRFRSTPLYDVLSAHPVIGRGANQLPAQRARLAMGVRGKNIHYPINQIQRRHWIAQGQRVGFAPAEVDDMI
DALTARTAGVVDEVSARLPRDFPRDVADAIFSGMLRLNAKLAAASPARA

Download         Length: 1350 bp

>T58573 NZ_CP013388:c868879-867530 [Burkholderia sp. BDU8]
GTGAGCGCGCGCCGCAGCACGCGCACGACGCGCCTGCATCTGTGGATGAACGGCCTGCCCGTCGGCTACTGGGAGCATGC
CCGCGACGGCGAGCGCCTCGTCTACTTCGACGAATGGATCGCGGACCCGCAAGGCCGCCCCCTGTCGCTTTCGCTGCCGT
TCACGCCGGGCAACCAGCCGTATCGCGGCCGGCTCGTCAGCGACTACTTCGACAACCTGCTGCCCGACAGCGAACCGATC
CGGCGCCGGATCGCGATGCGCTACAGAACGGGCGGCACGTCGCCGTTCGCGCTGCTCTCGACGCTCGGCCGCGATTGCGT
CGGCGCGCTGCAAATGCTGCCGCCCGACGAAACGCCGGACGATCTCGATCGCATTCGCGGGCACGCGCTCGCCGACGCGG
ACATCGCGCGCCTGCTGCGCGAGATCACGTCCGCGCCGCAAGCCGGGCGGCACGAGCCGCTCGACGATCTGCGCCTGTCG
ATCGCGGGCGCGCAGGAAAAGACCGCGCTGCTGCGCCATCGCGGCCGGTGGCTGCTGCCCGAAGGCAGCACGCCGACCAC
GCATATCCTGAAGCTGCCGCTCGGGCTCGTCGGCAACCGGCGCGCCGACATGCGCACGTCGGTCGAGAACGAATGGCTGT
GCTCGAAAATCGTCGCCGCGTACGGGCTGCCGATCGCGCATTGCGACATCGCGCATTTCGACGATCGGAAGGCGCTCGTC
GTCGAGCGCTTCGACCGCAAGCCGTCGAGCGATGCGCGCTGGCTCCTGCGCCTGCCGCAGGAAGACATGTGCCAGGCAAC
AGGCACGTCCGCATTCGACAAATATCAGGCCGACGGCGGACCGGGCATCGAGACGATCATGGACGTGCTCGCCGGCTCCG
AGCACGCGGCCGACCGCTACGCATTCTTCGCCGCGCAAATCGTGTTCTGGCTGCTCGCCGCGACCGACGGCCATGCGAAG
AACTTCAGCATCGCGCATCTGCCGGGCAACCGCTTTCGATCGACGCCGCTCTACGACGTGCTGTCCGCGCATCCGGTGAT
CGGTCGGGGTGCCAATCAATTGCCGGCGCAGCGCGCGCGGCTCGCGATGGGCGTGCGCGGCAAGAACATCCACTATCCGA
TCAACCAGATCCAGCGGCGGCACTGGATCGCGCAGGGCCAGCGCGTCGGCTTCGCGCCGGCCGAGGTCGACGACATGATC
GACGCGTTGACCGCGCGAACCGCGGGCGTCGTCGACGAAGTGTCGGCGCGGCTGCCGCGCGATTTTCCGCGCGACGTCGC
CGACGCGATCTTCAGCGGGATGCTTCGTCTGAACGCGAAACTCGCCGCGGCATCGCCGGCGCGAGCGTAG

Antitoxin


Download         Length: 143 a.a.        Molecular weight: 15315.83 Da        Isoelectric Point: 11.8039

>AT58573 WP_066492708.1 NZ_CP013388:c869304-868876 [Burkholderia sp. BDU8]
MAIIIEHEIKTLSQWRPILRGFRKAAGLTQAMLASHLGVTQQTYAQFEANPASASVERLFKVLRLLNVELTLTQTHVASA
KPAAKQAVAAPARKAAKTAGSGRVAAKRPALPASPSVPDLHAAERLPRSPRKSAAPKKREDW

Download         Length: 429 bp

>AT58573 NZ_CP013388:c869304-868876 [Burkholderia sp. BDU8]
ATGGCCATCATCATCGAACACGAGATCAAGACGCTCAGCCAATGGCGGCCCATCTTGCGCGGCTTCCGCAAGGCCGCCGG
ATTGACGCAAGCGATGCTCGCGAGCCACCTCGGCGTCACGCAGCAGACGTATGCGCAATTCGAGGCGAACCCGGCGTCGG
CGAGCGTCGAGCGGCTGTTCAAGGTGCTGCGCCTCCTCAACGTCGAGCTCACGCTGACCCAGACCCACGTCGCGTCTGCC
AAGCCCGCCGCGAAGCAAGCGGTCGCCGCGCCCGCGCGCAAAGCCGCGAAAACGGCAGGAAGCGGACGCGTCGCCGCAAA
GCGTCCCGCGTTGCCTGCGAGCCCATCCGTGCCCGACCTGCATGCCGCCGAGCGCCTGCCCCGCTCGCCGCGCAAGAGCG
CCGCCCCGAAGAAGCGGGAGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4FSB9

Antitoxin

Source ID Structure
AlphaFold DB A0A1B4FSC5

References