58571

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1948927..1950689 Replicon chromosome
Accession NZ_CP013387
Organism Burkholderia sp. BDU6

Toxin (Protein)


Gene name hipA Uniprot ID A0A1B4FMY4
Locus tag WS70_RS27325 Protein ID WP_059472904.1
Coordinates 1949352..1950689 (+) Length 446 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1B4FMY0
Locus tag WS70_RS27320 Protein ID WP_059472905.1
Coordinates 1948927..1949355 (+) Length 143 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WS70_RS27310 1945597..1947951 - 2355 WP_108034131.1 cellulose biosynthesis cyclic di-GMP-binding regulatory protein BcsB -
WS70_RS27320 1948927..1949355 + 429 WP_059472905.1 helix-turn-helix domain-containing protein Antitoxin
WS70_RS27325 1949352..1950689 + 1338 WP_059472904.1 type II toxin-antitoxin system HipA family toxin Toxin
WS70_RS27330 1950652..1951058 + 407 Protein_1618 haloacid dehalogenase-like hydrolase -
WS70_RS27335 1951167..1951610 - 444 WP_059597454.1 hypothetical protein -
WS70_RS27345 1951843..1952757 - 915 WP_059472901.1 LysR family transcriptional regulator -
WS70_RS27350 1952910..1953863 + 954 WP_059472943.1 agmatinase -
WS70_RS27355 1954278..1955681 + 1404 WP_059597456.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-71)


Sequences

Toxin        


Download         Length: 446 a.a.        Molecular weight: 49328.15 Da        Isoelectric Point: 7.8846

>T58571 WP_059472904.1 NZ_CP013387:1949352-1950689 [Burkholderia sp. BDU6]
VSARTARLHLWMNGLPVGYWEHARDGERLVYFDEWIADPQGRPLSLSLPFTPGNQPYRGRLVSDYFDNLLPDSEPIRRRI
AMRYRTGGTSPFELLSTLGRDCVGALQMLPPDETPDDLDRIRGHALADADIARLLREITSAPQAGQHEPLDDLRLSIAGA
QEKTALLRHRGRWLLPEGSTPTTHILKLPLGLVGNRRADMRTSVENEWLCSKIVAAYGLPIAHCDIAHFDDRKALVVERF
DRKPSSDARWLLRLPQEDMCQATGTSAFDKYQADGGPGIEAIMDVLAGSEHAADRYAFFAAQIVFWLLAATDGHAKNFSI
AHLPGNRFRSTPLYDVLSAHPVIGRGANQLPAQRARLAMGVRGKNLHYPINQIQRRHWIAQGQRVGFAPAEVDDMIDALT
ARTAGVVDEVSARLPRDFPRDVADAIFSGMLRLNAKLAAASPARA

Download         Length: 1338 bp

>T58571 NZ_CP013387:1949352-1950689 [Burkholderia sp. BDU6]
GTGAGCGCGCGCACGGCTCGCCTGCATCTGTGGATGAACGGCCTGCCCGTCGGCTACTGGGAGCATGCCCGCGACGGCGA
GCGCCTCGTCTACTTCGACGAATGGATCGCGGACCCGCAAGGCCGCCCCCTGTCGCTTTCGCTGCCGTTCACGCCGGGCA
ACCAGCCGTATCGCGGCCGGCTCGTCAGCGACTACTTCGACAACCTGCTGCCCGACAGCGAACCGATCCGGCGCCGGATC
GCGATGCGCTACAGAACGGGCGGCACGTCGCCGTTCGAGCTGCTCTCGACGCTCGGCCGCGATTGCGTCGGCGCGCTGCA
GATGCTGCCGCCCGACGAAACGCCGGACGATCTCGATCGCATTCGCGGGCACGCGCTCGCCGACGCGGACATCGCGCGCC
TGCTGCGCGAGATCACGTCCGCGCCGCAGGCCGGGCAGCACGAGCCGCTCGACGATCTGCGCCTGTCGATCGCGGGCGCG
CAGGAAAAGACCGCGCTGCTGCGCCATCGCGGCCGTTGGCTGCTGCCCGAAGGCAGCACGCCGACCACGCATATCCTGAA
GCTGCCGCTCGGGCTCGTCGGCAACCGGCGCGCCGACATGCGCACGTCGGTCGAGAACGAATGGCTGTGCTCGAAAATCG
TCGCAGCGTACGGACTGCCGATCGCGCATTGCGACATCGCGCATTTCGACGATCGGAAGGCGCTCGTCGTCGAGCGCTTC
GACCGCAAGCCGTCGAGCGATGCACGCTGGCTCCTGCGCCTGCCGCAGGAAGACATGTGCCAGGCGACAGGCACGTCCGC
ATTCGACAAATATCAGGCCGACGGCGGACCGGGTATCGAGGCGATCATGGACGTGCTCGCCGGCTCCGAGCACGCGGCCG
ACCGCTACGCATTCTTCGCGGCGCAGATCGTGTTCTGGCTGCTCGCCGCGACCGACGGCCATGCGAAGAACTTCAGCATC
GCGCATCTGCCGGGTAATCGCTTTCGATCGACGCCGCTCTACGACGTGCTGTCCGCGCATCCGGTGATCGGTCGGGGTGC
GAATCAATTGCCGGCGCAGCGCGCGCGGCTCGCGATGGGCGTGCGCGGCAAGAACCTCCACTATCCGATCAACCAGATCC
AGCGGCGGCACTGGATCGCGCAGGGCCAGCGCGTCGGCTTCGCGCCGGCCGAAGTCGACGACATGATCGACGCGTTGACC
GCGCGAACCGCAGGCGTCGTCGACGAAGTGTCGGCGCGGCTGCCGCGCGATTTTCCGCGAGACGTCGCCGACGCGATCTT
CAGCGGGATGCTTCGTCTGAATGCGAAGCTCGCCGCGGCATCGCCGGCGCGAGCATAG

Antitoxin


Download         Length: 143 a.a.        Molecular weight: 15356.93 Da        Isoelectric Point: 11.9043

>AT58571 WP_059472905.1 NZ_CP013387:1948927-1949355 [Burkholderia sp. BDU6]
MAITIEHGIKTLSQWRPILRGFRKAAGLTQAMLASRLGVTQQTYAQFEANPASASVERLVKVLRILDVELTLTQTYVASA
KPAAKQTVAAPARKVAKTTGGGRVAAKRPALPARPSVPDLHAAERLPRSPRKSAAPKKREDW

Download         Length: 429 bp

>AT58571 NZ_CP013387:1948927-1949355 [Burkholderia sp. BDU6]
ATGGCCATCACCATCGAACACGGGATCAAGACACTCAGCCAATGGCGGCCCATCTTGCGCGGCTTCCGCAAGGCCGCCGG
ATTGACGCAAGCGATGCTCGCGAGCCGCCTCGGCGTCACACAGCAGACGTATGCGCAATTCGAGGCAAACCCGGCGTCGG
CGAGCGTCGAGCGGCTGGTCAAGGTGCTGCGCATCCTCGACGTCGAGCTCACACTGACCCAAACCTACGTCGCTTCTGCC
AAGCCCGCCGCGAAGCAAACGGTCGCCGCGCCCGCGCGCAAAGTCGCGAAAACGACAGGAGGCGGACGCGTCGCCGCAAA
GCGTCCCGCGTTGCCTGCGAGGCCATCCGTGCCGGACCTGCACGCCGCCGAGCGCCTGCCCCGCTCGCCGCGCAAGAGCG
CCGCCCCGAAGAAGCGGGAGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4FMY4

Antitoxin

Source ID Structure
AlphaFold DB A0A1B4FMY0

References