Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1154310..1156057 Replicon chromosome
Accession NZ_CP013387
Organism Burkholderia sp. BDU6

Toxin (Protein)


Gene name doc Uniprot ID A0A1B4FLD3
Locus tag WS70_RS23775 Protein ID WP_059598485.1
Coordinates 1154310..1155206 (+) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1B4FLD6
Locus tag WS70_RS23780 Protein ID WP_059473933.1
Coordinates 1155203..1156057 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WS70_RS23740 1149711..1150799 - 1089 WP_059473927.1 porin -
WS70_RS23750 1151235..1151552 + 318 WP_059473928.1 non-heme iron oxygenase ferredoxin subunit -
WS70_RS23755 1151554..1151865 + 312 WP_059473929.1 hypothetical protein -
WS70_RS23760 1151900..1152967 + 1068 WP_059473930.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
WS70_RS23765 1152964..1153734 + 771 WP_059473931.1 SDR family oxidoreductase -
WS70_RS23770 1153766..1154293 + 528 WP_059474046.1 cupin domain-containing protein -
WS70_RS23775 1154310..1155206 + 897 WP_059598485.1 alpha/beta fold hydrolase Toxin
WS70_RS23780 1155203..1156057 + 855 WP_059473933.1 IclR family transcriptional regulator Antitoxin
WS70_RS23785 1156054..1156851 + 798 WP_059473934.1 SDR family oxidoreductase -
WS70_RS23790 1156844..1158517 + 1674 WP_059598484.1 thiamine pyrophosphate-binding protein -
WS70_RS23795 1158510..1159325 + 816 WP_059473936.1 aspartate dehydrogenase -
WS70_RS23800 1159366..1160856 + 1491 WP_059473937.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-280)

Antitoxin

Transcription regulator IclR, C-terminal

(143-265)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30451.46 Da        Isoelectric Point: 7.9774

>T58569 WP_059598485.1 NZ_CP013387:1154310-1155206 [Burkholderia sp. BDU6]
MSAISSTMNDAGATPFAGLLERFSERRAAAGAAGTIGYREAGGVRGERCPVVLLHGIGSGAASWVRQLDALGATRRALAW
DAPGYGASSCVAAESPVAADYAASLGAWLDALRIERCVLVGHSLGAIVAGAFARAASERLSGLLLISPAGGYGSAPADVR
AERRDSRLALLASLGPQGLAEQRSANMLSAHASDAARAWVRWNMARIVPAGYAQATHLLANADLAADLAHYRGRVAVAVG
ADDAITPPAACERIAQAARVGLQVIPRAGHAGYVEAPDAYGALIDAFCRQCDGQRGAA

Download         Length: 897 bp

>T58569 NZ_CP013387:1154310-1155206 [Burkholderia sp. BDU6]
ATGAGCGCGATTTCCTCGACGATGAACGACGCAGGCGCCACGCCGTTCGCCGGACTGCTCGAACGTTTTTCCGAGCGGCG
CGCTGCGGCGGGCGCCGCAGGCACGATCGGCTACCGGGAGGCCGGCGGCGTGCGCGGCGAGCGCTGTCCCGTCGTGCTGT
TGCACGGGATCGGATCGGGCGCGGCGTCGTGGGTGCGGCAGCTCGATGCGCTCGGCGCGACGCGCCGTGCGCTCGCGTGG
GACGCGCCCGGCTACGGCGCGTCGTCGTGCGTCGCCGCCGAGTCGCCTGTCGCGGCCGATTACGCGGCGTCGCTCGGCGC
ATGGCTCGACGCGCTGCGGATCGAACGCTGCGTGCTCGTCGGCCATTCGCTCGGCGCGATCGTCGCCGGCGCGTTCGCGC
GCGCCGCAAGCGAGCGTCTGTCAGGATTGCTGTTGATTTCGCCCGCGGGCGGCTATGGCAGTGCGCCCGCCGACGTGCGG
GCCGAGCGGCGCGACAGCCGTCTCGCGCTGCTCGCGTCGCTCGGCCCGCAAGGGCTCGCCGAGCAGCGCAGCGCGAACAT
GCTGTCCGCGCATGCGAGCGACGCGGCGCGGGCGTGGGTGCGCTGGAACATGGCGCGGATCGTGCCCGCCGGCTATGCGC
AGGCGACGCACCTGCTCGCGAACGCCGATCTCGCGGCCGACCTCGCGCATTACCGCGGCCGCGTGGCGGTCGCGGTCGGC
GCGGACGACGCGATCACGCCGCCCGCCGCATGCGAGCGGATCGCGCAGGCGGCGCGCGTCGGGTTGCAGGTAATTCCGCG
CGCGGGCCATGCGGGCTACGTCGAAGCGCCCGATGCGTATGGCGCGCTGATCGATGCGTTTTGCCGTCAATGCGACGGAC
AGCGAGGTGCGGCATGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 30988.48 Da        Isoelectric Point: 7.4658

>AT58569 WP_059473933.1 NZ_CP013387:1155203-1156057 [Burkholderia sp. BDU6]
MSAPLLKDADDAKNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIEGLRDATGFTTHIVIRDGRDVVFVAKAQNAGHAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAQLRALYPEPALERVTKATPETVDVLFGVIREDARRGYGIGNSAFERDISVVTAPVRNDASKIVAVVTVTVPR
PEIDASLVADGLIDKVLRAAAELSRRLNYRSDDENTYLKALGLR

Download         Length: 855 bp

>AT58569 NZ_CP013387:1155203-1156057 [Burkholderia sp. BDU6]
ATGAGCGCACCGCTGCTGAAAGACGCCGACGACGCGAAAAACGATTCGAACTATGTCGTACCGGGGCTCGAGCGCGGTCT
GCGGATTCTTGCCGAGTTCTCGCCGCGCGAACCGGTGCTCGGCGCGCCGGAGCTGTCGAAGCGGCTCGGCATTCCGCGCA
CGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGCGCGGACAAGGACCGCAATTATCGATTG
GGCGTCGCGGTGCTGCGCCTCGGCTTCGAATACCTGAGCTCGCTCGAGCTGACCGATCTCGGCTTGCCGGTGATCGAAGG
GCTGCGCGACGCGACGGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTCGTGTTCGTCGCGAAGGCGCAAA
ACGCGGGGCACGCGTTCGGCTCGGTGCGGGTGAACGTCGGCACGCGCTTGCCCGCGCATGCGACGACGCACGGCCACGTG
CTGATGGGCGACCTGTCGCTCGCTCAGTTGCGCGCGCTGTATCCGGAGCCTGCGCTCGAGCGCGTGACGAAGGCGACGCC
CGAGACCGTCGACGTGCTGTTCGGCGTGATCCGCGAAGACGCGCGGCGTGGCTACGGGATCGGCAACTCGGCTTTCGAGC
GCGACATCTCGGTCGTCACGGCGCCCGTGCGCAACGACGCGAGCAAGATCGTCGCGGTCGTCACGGTGACGGTGCCGCGG
CCGGAGATCGACGCGTCGCTCGTCGCCGACGGGCTGATCGACAAGGTGCTGCGCGCGGCGGCGGAGCTGTCGCGGCGGCT
GAACTACCGGTCCGACGACGAAAACACCTATTTGAAGGCATTGGGATTGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4FLD3

Antitoxin

Source ID Structure
AlphaFold DB A0A1B4FLD6

References