Detailed information of TA system TA058567

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 1791706..1792391
• Replicon: chromosome
• Accession: NZ_CP013384
• Organism: Burkholderia sp. LA-2-3-30-S1-D2

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: WS66_RS21095
• Protein ID: WP_082729046.1
• Coordinates: 1791706..1792128 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A1B4F764
• Locus tag: WS66_RS21100
• Protein ID: WP_059606948.1
• Coordinates: 1792125..1792391 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WS66_RS21075	1787493..1788032	-	540	WP_059606952.1	outer membrane protein assembly factor BamE	-
WS66_RS21080	1788203..1789366	-	1164	WP_059606738.1	amidohydrolase	-
WS66_RS21085	1789722..1790789	+	1068	WP_059606951.1	hypothetical protein	-
WS66_RS21090	1790758..1791663	+	906	WP_059606737.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
WS66_RS21095	1791706..1792128	-	423	WP_082729046.1	PIN domain-containing protein	Toxin
WS66_RS21100	1792125..1792391	-	267	WP_059606948.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
WS66_RS21105	1792667..1793686	-	1020	WP_059606732.1	acetyltransferase	-
WS66_RS21110	1793686..1794525	-	840	WP_059606730.1	N(5)-hydroxyornithine transformylase PvdF	-
WS66_RS21115	1794611..1796827	-	2217	WP_059606728.1	TonB-dependent siderophore receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-130)

Antitoxin

• SpoVT-AbrB domain (7-53)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 14720.85 Da
• Isoelectric Point: 7.8895

>T58567 WP_082729046.1 NZ_CP013384:c1792128-1791706 [Burkholderia sp. LA-2-3-30-S1-D2]
VTTLYMLDTNICSFIMRERPPAVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGRKASPKHAELVTAFVARLDGVLPWDTA
AVDATAAIRADLATRGTPIGANDASIAGHAIAAGAVLVTNNGREFSRVAGLSLEDWAASA

Nucleotide

• Length: 423 bp

>T58567 NZ_CP013384:c1792128-1791706 [Burkholderia sp. LA-2-3-30-S1-D2]
GTGACAACGCTCTACATGCTCGATACGAACATCTGTTCGTTCATCATGCGCGAGCGGCCGCCCGCGGTGCTGTCCCGGCT
GCAGTCGTGCGTCAACGCGCAGCACCGGATCGTCGTGTCGGCGATTACCTATGCCGAAATGCGATTCGGCGCGGTCGGCA
GAAAGGCATCGCCGAAGCATGCGGAACTCGTGACGGCGTTTGTCGCGCGGCTGGACGGTGTGCTGCCGTGGGATACCGCG
GCGGTCGATGCAACGGCTGCGATTCGTGCCGACCTTGCCACACGCGGGACACCGATCGGCGCGAACGATGCATCGATCGC
CGGTCATGCGATCGCGGCCGGTGCCGTGCTCGTCACGAACAATGGTCGCGAATTCAGCCGCGTCGCGGGGTTGTCGCTCG
AAGACTGGGCGGCCTCGGCCTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9844.11 Da
• Isoelectric Point: 4.5112

>AT58567 WP_059606948.1 NZ_CP013384:c1792391-1792125 [Burkholderia sp. LA-2-3-30-S1-D2]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWLSLASEPLADADFLVERPAVIEAGRFDLSGTDG
DAQTESGR

Nucleotide

• Length: 267 bp

>AT58567 NZ_CP013384:c1792391-1792125 [Burkholderia sp. LA-2-3-30-S1-D2]
ATGCGCACCGTATCCATTTTCAAGAACGCCAGGAACCAGGCAATCCGCATCCCGAAGGACATGGAATTCGAGGGTGTGAC
GGAACTCGAGATCCGTCGCGAGGGCGACACGCTGCTGCTGCGTCCGGTGCGGCCGACATGGCTGTCGTTGGCGAGTGAAC
CGCTGGCCGATGCCGACTTCCTCGTCGAGCGCCCGGCTGTCATCGAAGCCGGTCGTTTCGACCTGTCCGGCACGGATGGC
GACGCACAAACGGAGTCGGGCCGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1B4F764