Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1620629..1622394 Replicon chromosome
Accession NZ_CP013382
Organism Burkholderia sp. Bp5365 strain MSMB43

Toxin (Protein)


Gene name doc Uniprot ID A0A7U4SUI5
Locus tag AQ610_RS26180 Protein ID WP_006027423.1
Coordinates 1621480..1622394 (-) Length 305 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A7U4PAC5
Locus tag AQ610_RS26175 Protein ID WP_006027422.1
Coordinates 1620629..1621483 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AQ610_RS26155 1615845..1617335 - 1491 WP_006027418.1 aldehyde dehydrogenase -
AQ610_RS26160 1617361..1618176 - 816 WP_006027419.1 aspartate dehydrogenase -
AQ610_RS26165 1618169..1619842 - 1674 WP_043282768.1 thiamine pyrophosphate-binding protein -
AQ610_RS26170 1619835..1620632 - 798 WP_006027421.1 SDR family oxidoreductase -
AQ610_RS26175 1620629..1621483 - 855 WP_006027422.1 IclR family transcriptional regulator Antitoxin
AQ610_RS26180 1621480..1622394 - 915 WP_006027423.1 alpha/beta fold hydrolase Toxin
AQ610_RS26185 1622411..1622938 - 528 WP_009914832.1 cupin domain-containing protein -
AQ610_RS26190 1622977..1623747 - 771 WP_006027425.1 SDR family oxidoreductase -
AQ610_RS26195 1623744..1624811 - 1068 WP_006027426.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
AQ610_RS26200 1624846..1625157 - 312 WP_006027427.1 hypothetical protein -
AQ610_RS26205 1625159..1625476 - 318 WP_009914826.1 non-heme iron oxygenase ferredoxin subunit -
AQ610_RS26210 1625911..1626999 + 1089 WP_009914825.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(57-287)

Antitoxin

Transcription regulator IclR, C-terminal

(143-265)


Sequences

Toxin        


Download         Length: 305 a.a.        Molecular weight: 31147.07 Da        Isoelectric Point: 7.1483

>T58564 WP_006027423.1 NZ_CP013382:c1622394-1621480 [Burkholderia sp. Bp5365]
MSAISTTTAGASAMPFAALLERFAERHAAAGDAGTIGYREAGESYGERTEQAGRDPVVLLHGIGSGAASWVRQLDALGAT
RRALAWDAPGYGASSRVAAGSPVAADYAASLAAWLDALRIERCVLVGHSLGAIVAGAFARIASERLAGLLLISPAGGYGG
APADVRAERRDSRLALLASLGPQGLADERSANMLSAHASDTARAWVHWNMARIAPAGYAQAAHLLANADLASDLVHYRGR
VAVAVGGDDAITPPAACERIARAARVGLQVIPRAGHAGYVEAPDAYSALIDAFCRQCDGSRGAT

Download         Length: 915 bp

>T58564 NZ_CP013382:c1622394-1621480 [Burkholderia sp. Bp5365]
ATGAGCGCGATTTCCACGACGACAGCCGGCGCGAGCGCGATGCCTTTCGCCGCGCTGCTCGAACGCTTCGCCGAGCGACA
CGCGGCGGCGGGCGACGCGGGCACGATCGGCTACCGCGAGGCGGGCGAATCGTACGGCGAGCGCACTGAGCAAGCCGGGC
GCGATCCCGTCGTGCTGCTGCACGGGATCGGATCGGGTGCGGCGTCGTGGGTGCGCCAGCTCGACGCGCTCGGCGCGACG
CGTCGCGCGCTCGCGTGGGACGCGCCAGGCTATGGCGCATCGTCACGCGTCGCGGCCGGCTCGCCCGTCGCGGCCGACTA
CGCGGCGTCGCTCGCCGCGTGGCTCGACGCGCTGCGCATCGAACGCTGCGTGCTCGTCGGCCATTCGCTCGGCGCGATCG
TCGCCGGCGCGTTCGCGCGGATCGCGAGCGAGCGGCTTGCGGGATTGCTGCTGATTTCTCCTGCCGGCGGCTACGGCGGC
GCGCCCGCCGACGTGCGGGCCGAGCGGCGCGACAGCCGTCTCGCACTGCTCGCGTCGCTCGGCCCGCAAGGGCTCGCCGA
CGAGCGCAGCGCAAACATGTTGTCCGCGCATGCGAGCGACACGGCGCGCGCGTGGGTGCACTGGAACATGGCGCGCATCG
CGCCCGCCGGCTATGCGCAAGCGGCGCATCTGCTCGCGAACGCGGATCTCGCGTCCGATCTCGTCCATTACCGCGGCCGC
GTCGCGGTCGCCGTCGGCGGCGACGACGCGATCACGCCGCCCGCCGCATGCGAGCGGATTGCGCGCGCGGCGCGTGTTGG
GCTGCAGGTGATTCCCCGTGCGGGCCATGCCGGCTACGTTGAAGCGCCCGATGCGTACAGCGCGTTGATCGACGCTTTTT
GCCGTCAATGTGACGGATCGCGAGGCGCGACATGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31002.47 Da        Isoelectric Point: 7.4665

>AT58564 WP_006027422.1 NZ_CP013382:c1621483-1620629 [Burkholderia sp. Bp5365]
MSEPLLKDADNAKNDSTYVVPGLERGLRVLAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIEGLRDATGFTAHIVIRDGRDVVFVAKAQNAGHAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAELRALYPERELERVTKATPETVDALFDVIRADARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDAALVADGLIEKVVRAAGGLSRRLNYRADDENTYLKALGLR

Download         Length: 855 bp

>AT58564 NZ_CP013382:c1621483-1620629 [Burkholderia sp. Bp5365]
ATGAGCGAACCGCTACTGAAAGACGCCGACAACGCGAAGAATGATTCGACCTACGTAGTACCGGGGCTCGAGCGCGGGCT
GCGGGTCCTGGCCGAGTTCTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAGCTGTCGAAGCGGCTCGGCATTCCGCGCA
CGACGGTGTTCCGTCTGCTGCAGACGCTCGAGTCGCTCGGCTTTCTCGAGCGCGCGGACAAGGATCGCAATTATCGCCTC
GGCGTCGCGGTGTTGCGCCTCGGCTTCGAATACCTGAGCTCGCTCGAGCTGACTGATCTCGGCTTGCCGGTGATAGAAGG
CTTGCGCGATGCGACGGGCTTCACGGCGCACATCGTGATTCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGCAGA
ACGCGGGGCACGCGTTCGGCTCGGTGCGGGTGAACGTCGGCACGCGCCTGCCCGCGCACGCGACGACGCACGGCCACGTG
CTGATGGGCGACCTGTCGCTCGCCGAGTTGCGCGCGCTGTATCCGGAGCGGGAGCTCGAACGCGTGACGAAGGCGACGCC
CGAGACTGTCGACGCGCTCTTCGACGTGATTCGCGCCGATGCGCGGCGCGGCTACGGCATCGGCAACTCGGCGTTCGAGC
GCGATATCTCGGTCGTCACGGCGCCCGTGCGCAACGAGGCGAGCCGGATCGTCGCGGTCGTCACGGTGACGGTGCCGCGG
CCGGAGATCGATGCGGCGCTCGTCGCCGACGGGCTGATCGAGAAGGTCGTGCGCGCGGCGGGCGGACTGTCGCGGCGGCT
CAACTACCGGGCCGACGACGAAAACACCTATTTGAAGGCATTGGGATTGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4SUI5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4PAC5

References