Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1445741..1446396 Replicon chromosome
Accession NZ_CP013382
Organism Burkholderia sp. Bp5365 strain MSMB43

Toxin (Protein)


Gene name relE Uniprot ID A0A0F6LEW6
Locus tag AQ610_RS25375 Protein ID WP_006027262.1
Coordinates 1446100..1446396 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag AQ610_RS25370 Protein ID WP_004202809.1
Coordinates 1445741..1446097 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AQ610_RS25350 1440868..1441878 - 1011 WP_006027258.1 phage major capsid protein, P2 family -
AQ610_RS25355 1441923..1442732 - 810 WP_006027259.1 GPO family capsid scaffolding protein -
AQ610_RS25360 1442876..1444645 + 1770 WP_006027260.1 terminase ATPase subunit family protein -
AQ610_RS25365 1444642..1445697 + 1056 WP_006027261.1 phage portal protein -
AQ610_RS25370 1445741..1446097 - 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
AQ610_RS25375 1446100..1446396 - 297 WP_006027262.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AQ610_RS25380 1447061..1448176 - 1116 WP_041861678.1 DUF3396 domain-containing protein -
AQ610_RS25385 1448163..1448927 - 765 WP_006027264.1 VRR-NUC domain-containing protein -
AQ610_RS25390 1448924..1449457 - 534 WP_006027265.1 PAAR domain-containing protein -
AQ610_RS25395 1449560..1449682 - 123 WP_009914987.1 hypothetical protein -
AQ610_RS25400 1449916..1450569 - 654 WP_009914986.1 AAA family ATPase -
AQ610_RS25405 1450659..1450865 - 207 WP_006027267.1 ogr/Delta-like zinc finger family protein -
AQ610_RS25410 1450862..1451128 - 267 WP_006027268.1 ogr/Delta-like zinc finger family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1421088..1462361 41273


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10844.65 Da        Isoelectric Point: 10.1723

>T58563 WP_006027262.1 NZ_CP013382:c1446396-1446100 [Burkholderia sp. Bp5365]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T58563 NZ_CP013382:c1446396-1446100 [Burkholderia sp. Bp5365]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTCGACGGGCTTCGCGACCCGGTCGGTAGCGCGGCGATCAA
CCTGCGCATCGAGCGGGCAAAGCTTGGCAATCTCGGCCAATGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTACTTCGTGCGACGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCCGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT58563 WP_004202809.1 NZ_CP013382:c1446097-1445741 [Burkholderia sp. Bp5365]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT58563 NZ_CP013382:c1446097-1445741 [Burkholderia sp. Bp5365]
ATGAAAATCAGTGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAAGAAACAATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAATCCGCGCCTGATTCAAGCCGCGCTTGGGAACGTTGCGAAGGCGCGCGGCATGACGGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTACCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCGACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6LEW6

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References