Detailed information of TA system TA058562

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 853193..854913
• Replicon: chromosome
• Accession: NZ_CP013382
• Organism: Burkholderia sp. Bp5365 strain MSMB43

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A7U4SU12
• Locus tag: AQ610_RS22865
• Protein ID: WP_006028959.1
• Coordinates: 853193..854542 (-)
• Length: 450 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: AQ610_RS22870
• Protein ID: WP_006028958.1
• Coordinates: 854539..854913 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AQ610_RS22840	848767..849750	-	984	WP_006028964.1	agmatinase	-
AQ610_RS22845	849902..850816	+	915	WP_006028963.1	LysR family transcriptional regulator	-
AQ610_RS22850	851023..851472	+	450	WP_009915517.1	hypothetical protein	-
AQ610_RS22855	851613..852632	+	1020	WP_006028961.1	AAA family ATPase	-
AQ610_RS22860	852629..853165	+	537	WP_006028960.1	hypothetical protein	-
AQ610_RS22865	853193..854542	-	1350	WP_006028959.1	type II toxin-antitoxin system HipA family toxin	Toxin
AQ610_RS22870	854539..854913	-	375	WP_006028958.1	helix-turn-helix domain-containing protein	Antitoxin
AQ610_RS22875	855728..858052	+	2325	WP_006028957.1	cellulose biosynthesis cyclic di-GMP-binding regulatory protein BcsB	-
AQ610_RS22880	858057..859466	+	1410	WP_043283173.1	cellulase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (158-405)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-71)

Sequences

Toxin

Protein

• Length: 450 a.a.
• Molecular weight: 49632.56 Da
• Isoelectric Point: 9.0228

>T58562 WP_006028959.1 NZ_CP013382:c854542-853193 [Burkholderia sp. Bp5365]
VSARRARTARLHLWMNGLPVGYWEHARDGERLVYFDEWIADPQGRPLSLSLPFTPGNQPYRGRLVSDYFDNLLPDSEPIR
RRIAMRYRTGGTSPFELLATLGRDCVGALQMLPPDEAPDDLERIRGHALADADIARLLRDITSAPQAGEHEPLDDLRLSI
AGAQEKTALLRHRGRWLLPDGSTPTTHILKLPLGLVGNRRADMRTSVENEWLCSKIVAAYGLPVAHCDIAHFDGQKALVV
ERFDRRPSSDARWILRLPQEDMCQATGTSALDKYQADGGPGIETIMGVLAGSERAADRYAFFAAQIVFWLLAATDGHAKN
FSIAHLPGNRYRSTPLYDVLSAHPVIGRGANRLPAQRARLAMGVRGKHVHYLIHQIQRRHWIAQGQRVGFAPAEVDDIIG
ALTARTEGVADEVSARLPRDFPMDVADAIFNGMRRLSAKLAAGAAARAS

Nucleotide

• Length: 1350 bp

>T58562 NZ_CP013382:c854542-853193 [Burkholderia sp. Bp5365]
GTGAGCGCGCGCCGCGCGCGCACCGCGCGCCTTCACCTGTGGATGAACGGCCTGCCCGTCGGCTACTGGGAGCACGCGCG
CGACGGCGAGCGCCTCGTCTACTTCGACGAATGGATCGCGGACCCGCAAGGCCGCCCGCTGTCGCTGTCGCTGCCGTTCA
CGCCGGGCAACCAGCCGTATCGCGGCCGGCTCGTCAGCGACTACTTCGACAACCTGCTGCCCGACAGCGAGCCGATCCGC
CGGCGGATCGCGATGCGCTACAGGACGGGCGGCACGTCGCCGTTCGAGCTGCTCGCGACGCTCGGCCGCGATTGCGTCGG
CGCGCTGCAGATGCTGCCGCCCGACGAGGCGCCGGACGATCTCGAACGCATCCGCGGCCACGCGCTCGCCGATGCGGACA
TCGCACGCCTGCTGCGCGACATCACGTCCGCGCCGCAAGCCGGCGAGCACGAGCCGCTCGACGACCTGCGCCTGTCGATC
GCCGGCGCGCAGGAAAAGACCGCGCTGCTGCGCCATCGCGGCCGCTGGCTGCTGCCCGACGGCAGCACGCCGACCACGCA
CATCCTGAAGCTGCCGCTCGGGCTCGTCGGCAACCGGCGCGCCGACATGCGCACGTCGGTCGAGAACGAATGGCTGTGCT
CGAAGATCGTCGCCGCATACGGATTGCCGGTCGCGCATTGCGACATCGCGCATTTCGACGGCCAGAAGGCGCTCGTCGTC
GAGCGCTTCGACCGCAGGCCGTCGAGCGACGCGCGCTGGATTCTGCGCCTGCCGCAGGAAGACATGTGCCAGGCAACCGG
CACGTCCGCGCTCGACAAATATCAGGCGGATGGCGGGCCGGGCATCGAGACGATCATGGGCGTGCTCGCCGGCTCCGAGC
GCGCGGCCGACCGCTACGCGTTCTTCGCGGCGCAGATCGTGTTCTGGCTGCTCGCCGCGACCGACGGCCACGCGAAGAAC
TTCAGCATCGCGCATCTGCCGGGCAACCGCTATCGATCGACGCCGCTTTACGACGTGCTGTCCGCGCATCCGGTGATCGG
CCGCGGGGCGAACCGGTTGCCGGCGCAGCGCGCGCGGCTCGCGATGGGCGTGCGCGGCAAGCACGTCCATTACCTGATCC
ACCAGATCCAGCGGCGGCACTGGATCGCGCAGGGCCAGCGCGTCGGCTTCGCGCCGGCCGAAGTCGACGACATCATCGGC
GCGTTGACCGCGCGCACCGAGGGCGTCGCCGACGAAGTATCGGCCAGGCTGCCGCGAGATTTTCCGATGGACGTCGCCGA
TGCGATCTTCAACGGGATGCGTCGCCTGAGCGCGAAACTCGCGGCCGGCGCGGCCGCGCGAGCGTCGTGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 13827.14 Da
• Isoelectric Point: 11.8677

>AT58562 WP_006028958.1 NZ_CP013382:c854913-854539 [Burkholderia sp. Bp5365]
MAIIIEHEIKTLDQLRPILRGFRKVAGLTQAMLASRLGVTQQTYAQFEANPASASVERLFKVLRVLDVELTLTHVHTTSA
KQVVKQAAAPARKAANRPMPAPRAAERTPRPARKRAAPKQREDW

Nucleotide

• Length: 375 bp

>AT58562 NZ_CP013382:c854913-854539 [Burkholderia sp. Bp5365]
ATGGCCATCATCATCGAACACGAGATCAAGACGCTCGACCAATTGCGGCCCATCCTGCGAGGCTTCCGCAAGGTGGCCGG
ATTGACGCAAGCGATGCTCGCGAGCCGTCTCGGCGTCACGCAGCAGACGTATGCGCAATTCGAGGCGAACCCGGCGTCGG
CGAGCGTCGAGCGGCTGTTCAAGGTGCTGCGCGTCCTCGACGTCGAGCTCACGCTGACCCACGTCCATACCACTTCCGCG
AAGCAAGTCGTCAAGCAGGCCGCCGCGCCCGCGCGCAAGGCCGCGAACCGGCCGATGCCCGCCCCGCGCGCCGCCGAGCG
CACGCCCCGCCCCGCGCGCAAGCGCGCCGCCCCGAAGCAGCGGGAGGACTGGTGA

Structures

Toxin

• AlphaFold DB: A0A7U4SU12