58560

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ParST/RES-Xre
Location 16387..17366 Replicon plasmid pMSMB43
Accession NZ_CP013381
Organism Burkholderia sp. Bp5365 strain MSMB43

Toxin (Protein)


Gene name ParT Uniprot ID A0A7U4P7N2
Locus tag AQ610_RS18320 Protein ID WP_009917390.1
Coordinates 16887..17366 (+) Length 160 a.a.

Antitoxin (Protein)


Gene name ParS Uniprot ID A0A7U4P7N6
Locus tag AQ610_RS18315 Protein ID WP_006029252.1
Coordinates 16387..16890 (+) Length 168 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AQ610_RS18295 11943..12254 + 312 WP_009917392.1 hypothetical protein -
AQ610_RS34050 12235..12576 + 342 WP_009917391.1 hypothetical protein -
AQ610_RS34055 12642..12899 + 258 WP_080595248.1 hypothetical protein -
AQ610_RS18300 12945..13823 + 879 WP_006029255.1 3'-5' exonuclease -
AQ610_RS18305 14007..14831 + 825 WP_006029254.1 hypothetical protein -
AQ610_RS18310 14837..16320 + 1484 Protein_16 site-specific integrase -
AQ610_RS18315 16387..16890 + 504 WP_006029252.1 MbcA/ParS/Xre antitoxin family protein Antitoxin
AQ610_RS18320 16887..17366 + 480 WP_009917390.1 RES family NAD+ phosphorylase Toxin
AQ610_RS18325 17769..19394 - 1626 WP_043283261.1 hypothetical protein -
AQ610_RS36190 19521..19925 + 405 WP_144411843.1 hypothetical protein -
AQ610_RS18335 20081..20368 - 288 WP_006029250.1 PAAR domain-containing protein -
AQ610_RS36195 20380..21339 - 960 WP_141668135.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - bspI2 / bspR2 1..305114 305114


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(5-142)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(119-164)


Sequences

Toxin        


Download         Length: 160 a.a.        Molecular weight: 17326.66 Da        Isoelectric Point: 5.6628

>T58560 WP_009917390.1 NZ_CP013381:16887-17366 [Burkholderia sp. Bp5365]
MTVALWRIATDTPDYTADDLSGEGAKRTGGRWNRSGRAVLYTASNIALACLETVVHLSGGDLPLNRYLVRLEVPDEVWAK
ARTLDATSAPVGWDALPAGKVSLDLGDAWLSEGATALYCVPSVVVPEEVNVLINPAHLDTRHITATKLRRWTYDARVWA

Download         Length: 480 bp

>T58560 NZ_CP013381:16887-17366 [Burkholderia sp. Bp5365]
ATGACGGTTGCGCTCTGGCGAATCGCAACCGACACGCCCGACTACACGGCGGACGACCTAAGCGGCGAAGGGGCGAAACG
CACCGGTGGTCGCTGGAACCGGTCGGGTCGCGCCGTGCTGTACACGGCCTCGAACATCGCGCTCGCCTGCCTCGAGACAG
TTGTTCATCTGAGCGGCGGAGACTTGCCACTCAACCGTTATCTGGTCCGCCTCGAGGTCCCCGACGAGGTGTGGGCGAAG
GCTCGCACCCTCGATGCGACATCGGCACCAGTGGGCTGGGACGCTTTGCCGGCCGGCAAGGTCAGTCTGGATCTCGGTGA
CGCGTGGCTGTCAGAGGGCGCTACCGCGCTGTACTGCGTGCCGTCGGTCGTCGTCCCGGAGGAGGTGAACGTGCTGATCA
ATCCCGCGCACCTGGATACGCGACACATCACTGCTACCAAGCTGCGCCGTTGGACCTATGACGCGCGCGTCTGGGCATAG

Antitoxin


Download         Length: 168 a.a.        Molecular weight: 18484.30 Da        Isoelectric Point: 9.6518

>AT58560 WP_006029252.1 NZ_CP013381:16387-16890 [Burkholderia sp. Bp5365]
MSAIEKRHALPARARPRAVEPHELELLDFQRIYRASPMERIDWIKHGVDAHTVILLADRMATTQDRLMGVLGFPRTTVVR
KSKAKQPLSTEHTERVVGLSKLIGQVQSMVEESGEPAGFDAAHWVAQWIERTNPALGGRKPAELMDTVAGQELVGAVLAR
MQSGAYA

Download         Length: 504 bp

>AT58560 NZ_CP013381:16387-16890 [Burkholderia sp. Bp5365]
ATGAGCGCGATCGAGAAACGACATGCCCTGCCTGCACGCGCGCGGCCGCGTGCGGTCGAGCCGCACGAGCTCGAATTGCT
CGACTTTCAGCGGATTTACCGCGCCTCGCCGATGGAACGTATTGACTGGATCAAGCATGGGGTCGACGCCCACACCGTGA
TTCTGCTCGCCGATCGCATGGCGACCACGCAGGACCGGCTCATGGGCGTCCTCGGATTTCCGCGAACGACGGTGGTCCGC
AAGTCGAAGGCAAAACAGCCGCTGTCAACCGAGCACACAGAGCGCGTTGTGGGCCTGTCGAAGCTGATCGGTCAGGTTCA
GTCTATGGTTGAGGAATCCGGCGAACCGGCCGGGTTCGACGCCGCTCATTGGGTCGCGCAGTGGATCGAGCGGACCAATC
CCGCTTTGGGTGGCCGCAAGCCGGCGGAATTGATGGATACCGTTGCAGGCCAGGAGCTCGTCGGCGCCGTGCTCGCACGG
ATGCAAAGCGGAGCATATGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4P7N2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4P7N6

References