Detailed information of TA system TA058558

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 3962852..3963552
• Replicon: chromosome
• Accession: NZ_CP013378
• Organism: Burkholderia pseudomultivorans strain SUB-INT23-BP2

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: WS57_RS30620
• Protein ID: WP_069245256.1
• Coordinates: 3962852..3963229 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: A0A132EQT4
• Locus tag: WS57_RS30625
• Protein ID: WP_009688335.1
• Coordinates: 3963229..3963552 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WS57_RS30595	3958558..3959013	+	456	WP_040127911.1	VOC family protein	-
WS57_RS30600	3959081..3960631	-	1551	WP_040127912.1	sodium:solute symporter family protein	-
WS57_RS30605	3960628..3960870	-	243	WP_009688332.1	DUF3311 domain-containing protein	-
WS57_RS30610	3961069..3961986	-	918	WP_069245255.1	spermidine synthase	-
WS57_RS30615	3962276..3962530	+	255	WP_009688334.1	hypothetical protein	-
WS57_RS30620	3962852..3963229	+	378	WP_069245256.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
WS57_RS30625	3963229..3963552	+	324	WP_009688335.1	helix-turn-helix domain-containing protein	Antitoxin
WS57_RS30630	3963575..3964066	-	492	WP_069245257.1	DNA-deoxyinosine glycosylase	-
WS57_RS30635	3964063..3964677	-	615	WP_059479203.1	chorismate lyase	-
WS57_RS30640	3964686..3966584	-	1899	WP_069245258.1	molecular chaperone HtpG	-
WS57_RS30645	3966735..3968195	-	1461	WP_069245259.1	PLP-dependent aminotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (22-115)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13638.62 Da
• Isoelectric Point: 9.5410

>T58558 WP_069245256.1 NZ_CP013378:3962852-3963229 [Burkholderia pseudomultivorans]
MGINSSMAPYTKPLYWLGSARKDLKAMPEAVQDTFGYALYLAQTGRKHDQAKPLRGFGSAGVLEVVESEDNGTYRAVYTV
KLGSAVYVLHCFQKKSSSGIATPKPDVDLVRERLKAAEAHAMGEK

Nucleotide

• Length: 378 bp

>T58558 NZ_CP013378:3962852-3963229 [Burkholderia pseudomultivorans]
ATGGGTATAAATTCATCGATGGCTCCGTACACCAAACCGCTCTACTGGCTCGGCTCGGCACGCAAGGATTTGAAAGCGAT
GCCCGAAGCGGTGCAGGACACGTTCGGCTACGCGCTGTATCTGGCCCAGACGGGAAGAAAGCACGATCAGGCCAAACCGT
TGAGGGGCTTTGGATCGGCCGGCGTGCTCGAGGTCGTGGAGTCGGAGGACAACGGCACGTATCGTGCCGTCTATACGGTG
AAACTGGGTAGCGCCGTCTATGTGCTGCACTGCTTTCAGAAGAAATCGTCCAGCGGTATCGCTACGCCGAAGCCGGACGT
CGATCTGGTTCGCGAGCGTCTGAAGGCAGCCGAAGCACACGCAATGGGAGAAAAGTGA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11749.69 Da
• Isoelectric Point: 7.2791

>AT58558 WP_009688335.1 NZ_CP013378:3963229-3963552 [Burkholderia pseudomultivorans]
MIEIEPGSGNVYADLGMPDAEEMRVKAQLAAKIAEIIKARKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHPEAEGHIEVVFAA

Nucleotide

• Length: 324 bp

>AT58558 NZ_CP013378:3963229-3963552 [Burkholderia pseudomultivorans]
ATGATCGAAATCGAACCGGGCAGCGGCAACGTCTACGCGGACCTCGGCATGCCCGATGCCGAAGAAATGCGCGTGAAGGC
TCAACTCGCCGCCAAGATCGCGGAGATCATCAAGGCGCGGAAATGGACGCAGCAGCACGCGGCCCGGTTGCTGGGCATGA
CGCAACCCAAGCTGTCGAACATGCTGCGCGGGCAGTTTCGCGGCGTGAGCGAAGCAAAGATGCTGGACTGTCTCGCCAAG
CTCGGGCGCGACGTACAGATCGTCGTGGGGCCGGACCGTCATCCGGAAGCCGAAGGACACATCGAAGTTGTCTTCGCTGC
CTGA

Structures

Antitoxin

• AlphaFold DB: A0A132EQT4