Detailed information of TA system TA058557

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 3140573..3141249
• Replicon: chromosome
• Accession: NZ_CP013378
• Organism: Burkholderia pseudomultivorans strain SUB-INT23-BP2

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: WS57_RS26780
• Protein ID: WP_081056911.1
• Coordinates: 3140833..3141249 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A132ESV6
• Locus tag: WS57_RS26775
• Protein ID: WP_009694207.1
• Coordinates: 3140573..3140836 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WS57_RS26760	3136224..3138446	+	2223	WP_059479462.1	TonB-dependent siderophore receptor	-
WS57_RS26765	3138505..3139344	+	840	WP_069245079.1	N(5)-hydroxyornithine transformylase PvdF	-
WS57_RS26770	3139344..3140360	+	1017	WP_069245080.1	acetyltransferase	-
WS57_RS26775	3140573..3140836	+	264	WP_009694207.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
WS57_RS26780	3140833..3141249	+	417	WP_081056911.1	PIN domain-containing protein	Toxin
WS57_RS26785	3141414..3143108	-	1695	WP_059601404.1	AMP-binding protein	-
WS57_RS26790	3143548..3144711	+	1164	WP_069245081.1	amidohydrolase	-
WS57_RS26795	3144839..3146182	-	1344	WP_069245082.1	cobyrinate a,c-diamide synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-130)

Antitoxin

• SpoVT-AbrB domain (7-50)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 14796.01 Da
• Isoelectric Point: 8.5393

>T58557 WP_081056911.1 NZ_CP013378:3140833-3141249 [Burkholderia pseudomultivorans]
VTALYMLDTNICSFIMRERPAAVLSRLQACVDAQHRIVVSAITYAEMRFGAIGRKASPKHADLVTAFVARLDGVLPWDTA
AIDATVTVRTALAARGTPIGANDASIAGHAIAAGAVLVTNNSREFRRVERLSFEDWAA

Nucleotide

• Length: 417 bp

>T58557 NZ_CP013378:3140833-3141249 [Burkholderia pseudomultivorans]
GTGACCGCGCTCTACATGCTCGATACGAACATCTGCTCGTTCATCATGCGCGAGCGGCCGGCGGCGGTCCTGTCGCGGCT
GCAGGCGTGCGTCGATGCGCAGCACCGGATCGTCGTGTCGGCGATTACCTATGCGGAAATGCGGTTCGGCGCGATCGGCA
GGAAAGCGTCGCCGAAGCATGCGGATCTCGTCACGGCCTTCGTCGCGCGGCTGGACGGCGTGCTGCCGTGGGACACGGCG
GCGATCGATGCGACCGTCACCGTTCGCACGGCGCTTGCCGCGCGCGGCACGCCGATCGGCGCGAACGACGCGTCGATTGC
CGGGCATGCGATCGCGGCCGGCGCGGTACTCGTGACGAACAACAGTCGCGAATTCCGCCGGGTCGAGCGCTTGTCGTTCG
AGGACTGGGCGGCTTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9728.01 Da
• Isoelectric Point: 4.5112

>AT58557 WP_009694207.1 NZ_CP013378:3140573-3140836 [Burkholderia pseudomultivorans]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWMSLASEPLADADFLAERPAVVESGRFDLPGDDA
APTESGR

Nucleotide

• Length: 264 bp

>AT58557 NZ_CP013378:3140573-3140836 [Burkholderia pseudomultivorans]
ATGCGTACCGTTTCCATTTTCAAGAACGCCCGTAACCAGGCGATCCGCATCCCGAAGGACATGGAATTCGAGGGGGTGAC
GGAACTCGAGATCCGCCGGGAGGGCGACACGCTGCTGTTGCGTCCGGTGCGTCCGACCTGGATGTCGCTCGCGAGCGAGC
CGCTGGCCGACGCCGACTTCCTCGCCGAACGTCCGGCCGTCGTCGAATCCGGCCGCTTCGACCTGCCCGGCGACGATGCC
GCGCCGACGGAGTCCGGCCGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A132ESV6