Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2691912..2692498 Replicon chromosome
Accession NZ_CP013378
Organism Burkholderia pseudomultivorans strain SUB-INT23-BP2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag WS57_RS24765 Protein ID WP_009689534.1
Coordinates 2692115..2692498 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag WS57_RS24760 Protein ID WP_059514585.1
Coordinates 2691912..2692118 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WS57_RS24750 2687325..2689703 + 2379 WP_208610305.1 DUF1343 domain-containing protein -
WS57_RS36195 2689927..2690166 + 240 WP_081056715.1 hypothetical protein -
WS57_RS24755 2690982..2691431 + 450 WP_059514569.1 CBS domain-containing protein -
WS57_RS37260 2691452..2691733 + 282 WP_155741123.1 hypothetical protein -
WS57_RS24760 2691912..2692118 + 207 WP_059514585.1 DUF2191 domain-containing protein Antitoxin
WS57_RS24765 2692115..2692498 + 384 WP_009689534.1 PIN domain-containing protein Toxin
WS57_RS24770 2692748..2693610 + 863 Protein_2345 UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) -
WS57_RS24775 2694107..2694850 + 744 WP_155741124.1 hypothetical protein -
WS57_RS24780 2695110..2696360 + 1251 WP_038455837.1 IS256 family transposase -
WS57_RS24785 2696619..2697059 - 441 WP_069244945.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2674466..2840471 166005


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-115)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14322.62 Da        Isoelectric Point: 6.0702

>T58556 WP_009689534.1 NZ_CP013378:2692115-2692498 [Burkholderia pseudomultivorans]
MSVLVDTSVWVEHFRRPLPALIQLLRVDDVLTHPLVMLELTCGTPPEPRAQTLGDLALLRQTRLATPGEVADWIERERLY
GRGCGAVDCTLLASALLTPSTWLWTRDRRLAQLAEQFGVHYVPPDMH

Download         Length: 384 bp

>T58556 NZ_CP013378:2692115-2692498 [Burkholderia pseudomultivorans]
ATGAGCGTTCTGGTCGATACGTCCGTTTGGGTCGAGCATTTCCGACGGCCGCTACCGGCGCTCATCCAATTGCTCCGCGT
CGACGACGTTTTGACGCATCCGCTAGTGATGCTCGAGCTCACGTGCGGGACGCCGCCCGAACCGCGGGCCCAAACGTTGG
GAGACCTCGCGCTTTTGCGCCAAACGCGCCTCGCGACGCCAGGGGAAGTAGCGGACTGGATCGAGCGGGAACGGCTGTAC
GGGCGCGGATGCGGTGCGGTGGATTGCACGTTGCTGGCATCAGCGCTATTGACCCCTAGCACTTGGCTCTGGACGCGCGA
TCGGCGCCTCGCGCAACTGGCAGAGCAATTCGGAGTTCACTACGTACCGCCTGACATGCATTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7445.48 Da        Isoelectric Point: 7.2029

>AT58556 WP_059514585.1 NZ_CP013378:2691912-2692118 [Burkholderia pseudomultivorans]
MRTTVTVDDTLYARALELAEPGMAPADLFRAALETFVRVQAGHRLAALGGRAPDMPDVPRRHQESATR

Download         Length: 207 bp

>AT58556 NZ_CP013378:2691912-2692118 [Burkholderia pseudomultivorans]
ATGCGTACCACCGTCACCGTTGACGATACTCTCTACGCGCGCGCTCTAGAACTCGCCGAGCCGGGCATGGCGCCGGCCGA
CCTATTCCGCGCCGCACTGGAAACGTTCGTGCGTGTCCAAGCCGGCCATCGCCTTGCCGCGCTTGGCGGGCGGGCCCCCG
ACATGCCTGACGTGCCACGCCGCCACCAGGAGTCAGCTACCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References