Detailed information of TA system TA058555

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 163053..163690
• Replicon: chromosome
• Accession: NZ_CP013378
• Organism: Burkholderia pseudomultivorans strain SUB-INT23-BP2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: WS57_RS13700
• Protein ID: WP_059514751.1
• Coordinates: 163289..163690 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A132EWB1
• Locus tag: WS57_RS13695
• Protein ID: WP_006408845.1
• Coordinates: 163053..163289 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WS57_RS13675	158199..158741	+	543	WP_009695322.1	hypothetical protein	-
WS57_RS13680	158959..159990	+	1032	WP_059514747.1	helix-turn-helix domain-containing protein	-
WS57_RS13685	160061..161164	-	1104	WP_059514749.1	hypothetical protein	-
WS57_RS13690	161161..162864	-	1704	WP_069244414.1	thiamine pyrophosphate-binding protein	-
WS57_RS13695	163053..163289	+	237	WP_006408845.1	hypothetical protein	Antitoxin
WS57_RS13700	163289..163690	+	402	WP_059514751.1	type II toxin-antitoxin system VapC family toxin	Toxin
WS57_RS13705	163802..165190	-	1389	WP_040126410.1	L-serine ammonia-lyase	-
WS57_RS13710	165221..166363	-	1143	WP_040128681.1	alginate lyase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-121)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14935.12 Da
• Isoelectric Point: 5.7429

>T58555 WP_059514751.1 NZ_CP013378:163289-163690 [Burkholderia pseudomultivorans]
MPRYMLDTNMCVYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVTVCANPARERRNLAALIEDIPVAPFDGAAAQA
YGPIREATRERKKDHLDKLIGAHAVSLDVVLVTNNERDFASYPGLRLENWLIG

Nucleotide

• Length: 402 bp

>T58555 NZ_CP013378:163289-163690 [Burkholderia pseudomultivorans]
ATGCCGCGCTACATGCTCGACACCAACATGTGCGTCTATCTGATGAAGAACCAGCCGGAGCAGGTCGCGCGGCGTTTCGC
GCAGTGCTACACGGGGGACGTCGTCATGTCGGCGATCACCTATGCGGAACTCGAGTACGGCGTGACGGTATGTGCCAATC
CGGCCCGCGAACGCCGCAATCTCGCCGCGCTGATCGAGGATATCCCGGTTGCGCCGTTCGACGGAGCGGCTGCGCAGGCA
TATGGCCCCATTCGCGAGGCGACGCGGGAACGCAAGAAGGATCATCTCGACAAGCTGATCGGCGCGCACGCGGTATCGCT
CGACGTCGTGCTGGTGACCAACAACGAGCGTGATTTCGCGAGTTATCCGGGCTTGAGGCTCGAGAACTGGCTGATCGGCT
AG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8915.00 Da
• Isoelectric Point: 5.8651

>AT58555 WP_006408845.1 NZ_CP013378:163053-163289 [Burkholderia pseudomultivorans]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPARRPLTGVLGKFAKFGPDFMAEGRGDQEQAEREGW

Nucleotide

• Length: 237 bp

>AT58555 NZ_CP013378:163053-163289 [Burkholderia pseudomultivorans]
ATGCATACCACCCGGGTCTTCCGGAATGGCAACTCGCAGGCGGTGCGGATTCCTGCGGATCTGGCTTATGAGCGCAGCGA
TATCGAACTCGAAATCGAGCGTGTCGGTGACGAAATTCGCATCCGTCCTGCGCGGCGGCCGCTGACCGGCGTGCTCGGCA
AGTTCGCGAAATTCGGGCCGGATTTCATGGCCGAGGGGCGCGGCGATCAGGAACAGGCCGAGCGCGAGGGCTGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A132EWB1