Detailed information of TA system TA058552

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 2328697..2329344
• Replicon: chromosome
• Accession: NZ_CP013377
• Organism: Burkholderia pseudomultivorans strain SUB-INT23-BP2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: WS57_RS09980
• Protein ID: WP_059519052.1
• Coordinates: 2328697..2329041 (+)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A132EUP1
• Locus tag: WS57_RS09985
• Protein ID: WP_009692881.1
• Coordinates: 2329045..2329344 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WS57_RS09970	2325199..2326632	-	1434	WP_059519050.1	aldehyde dehydrogenase family protein	-
WS57_RS09975	2326661..2328301	-	1641	WP_059519051.1	acetolactate synthase large subunit	-
WS57_RS09980	2328697..2329041	+	345	WP_059519052.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
WS57_RS09985	2329045..2329344	+	300	WP_009692881.1	putative addiction module antidote protein	Antitoxin
WS57_RS09990	2329384..2330670	-	1287	WP_059519053.1	DUF445 domain-containing protein	-
WS57_RS09995	2330989..2331729	+	741	WP_009692883.1	IclR family transcriptional regulator	-
WS57_RS10000	2331827..2333446	+	1620	WP_059519054.1	OPT/YSL family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (26-98)

Antitoxin

• Uncharacterized protein HI1420 (5-93)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 13117.96 Da
• Isoelectric Point: 8.8567

>T58552 WP_059519052.1 NZ_CP013377:2328697-2329041 [Burkholderia pseudomultivorans]
MVYIPTTTRYTPPIYSIRTTDVFDAWFDALQDRVAKRRIQARIDRLSMGNPGDWKSAGAPIVEMRIDHGPGYRVYYTRRE
SIWVILLCGGDKSTQRADIRAAHAMLAHLDFDTE

Nucleotide

• Length: 345 bp

>T58552 NZ_CP013377:2328697-2329041 [Burkholderia pseudomultivorans]
ATGGTTTACATACCGACGACAACACGCTACACTCCGCCCATCTACAGCATTCGCACCACCGACGTGTTCGACGCGTGGTT
CGACGCGCTGCAGGACCGCGTCGCGAAACGCCGCATTCAGGCGCGCATCGACCGGCTGTCGATGGGCAATCCGGGCGACT
GGAAATCCGCCGGCGCGCCGATCGTCGAAATGCGGATCGACCACGGCCCCGGCTACCGCGTCTACTACACGCGGCGGGAG
TCGATCTGGGTGATCCTGCTTTGCGGCGGCGACAAGTCGACGCAACGGGCGGACATCCGCGCCGCGCACGCGATGCTCGC
GCATCTCGATTTCGATACGGAGTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10690.10 Da
• Isoelectric Point: 6.6384

>AT58552 WP_009692881.1 NZ_CP013377:2329045-2329344 [Burkholderia pseudomultivorans]
MDKIKTRPWDSAEHLKTEDDMADYFDACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGSKAHA

Nucleotide

• Length: 300 bp

>AT58552 NZ_CP013377:2329045-2329344 [Burkholderia pseudomultivorans]
ATGGACAAGATCAAGACCCGGCCCTGGGATTCGGCCGAACACCTGAAAACCGAAGACGACATGGCCGATTATTTCGACGC
CTGTCTGCAGGAAGCCGGCGACGATCCGGCATTCATCGCGCATGCGCTCGGCGTGATCGCACGCGCGCGCGGCATGTCGC
AGGTCGCACGCGATGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAACCCGAGCTTCGGCACG
ATCCTGAAGGTCATCAAGGCGCTCGGCCTGCAGCTGCACGGCTCGAAAGCACACGCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A132EUP1