Detailed information of TA system TA058551

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2195863..2196465
• Replicon: chromosome
• Accession: NZ_CP013377
• Organism: Burkholderia pseudomultivorans strain SUB-INT23-BP2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A6P2QRH5
• Locus tag: WS57_RS09340
• Protein ID: WP_059771351.1
• Coordinates: 2195863..2196045 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: WS57_RS09345
• Protein ID: WP_069244092.1
• Coordinates: 2196070..2196465 (+)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WS57_RS09320	2191665..2192924	-	1260	WP_059514087.1	phage portal protein	-
WS57_RS09325	2192929..2193114	-	186	WP_059514084.1	hypothetical protein	-
WS57_RS09330	2193111..2194823	-	1713	WP_069244091.1	terminase large subunit	-
WS57_RS09335	2194833..2195318	-	486	WP_081337594.1	phage terminase small subunit P27 family	-
WS57_RS35615	2195466..2195822	-	357	WP_081337595.1	HNH endonuclease	-
WS57_RS09340	2195863..2196045	+	183	WP_059771351.1	type II toxin-antitoxin system HicA family toxin	Toxin
WS57_RS09345	2196070..2196465	+	396	WP_069244092.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
WS57_RS35620	2196928..2199237	-	2310	WP_155774276.1	patatin-like phospholipase family protein	-
WS57_RS09355	2199645..2200070	-	426	WP_069244094.1	hypothetical protein	-
WS57_RS09360	2200119..2200367	-	249	WP_069244095.1	phage portal protein	-
WS57_RS09365	2200364..2200873	-	510	WP_069244096.1	hypothetical protein	-
WS57_RS09370	2200870..2201151	-	282	WP_069244362.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2157753..2224676	66923

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-123)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6774.99 Da
• Isoelectric Point: 11.1039

>T58551 WP_059771351.1 NZ_CP013377:2195863-2196045 [Burkholderia pseudomultivorans]
MNSTELIKRIKADGWYHVHTVGSHHQFKHPTKPGKVTVPHPKKDLLIATVRSILKQAGLK

Nucleotide

• Length: 183 bp

>T58551 NZ_CP013377:2195863-2196045 [Burkholderia pseudomultivorans]
ATGAACAGCACCGAACTCATCAAGCGAATCAAGGCCGATGGCTGGTACCACGTACACACTGTCGGGTCGCACCACCAGTT
CAAGCACCCGACAAAGCCGGGCAAGGTAACGGTGCCTCACCCGAAGAAAGACCTGCTGATCGCTACGGTGCGCAGCATCC
TGAAGCAAGCCGGCCTGAAATGA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14294.15 Da
• Isoelectric Point: 4.6081

>AT58551 WP_069244092.1 NZ_CP013377:2196070-2196465 [Burkholderia pseudomultivorans]
MLYPLYVHVGDAKHAHGVTFPDFPGCFAAADTWEELPAAVQEAVEAHFYDEEGPVPAPSALEALTRNPEYEGGVWMLFDI
DLSKINSKAVRFNVSMPERLLQQIDAAAGARKLSRSAFLALAAEHEMAAHA

Nucleotide

• Length: 396 bp

>AT58551 NZ_CP013377:2196070-2196465 [Burkholderia pseudomultivorans]
ATGCTCTATCCACTCTATGTCCACGTAGGCGACGCCAAGCACGCGCACGGCGTCACATTCCCTGACTTCCCGGGCTGCTT
CGCGGCGGCCGACACCTGGGAAGAACTTCCCGCTGCCGTACAGGAAGCGGTCGAAGCGCACTTCTACGATGAGGAAGGCC
CGGTGCCGGCGCCGTCCGCGTTGGAAGCGCTTACCAGAAATCCCGAGTACGAAGGCGGCGTCTGGATGCTCTTCGATATC
GATCTGTCGAAGATCAATTCGAAGGCCGTGCGCTTTAACGTGAGCATGCCCGAACGGCTCCTGCAGCAGATCGATGCGGC
AGCGGGCGCACGCAAGCTGTCGCGCTCGGCATTCCTCGCGCTTGCCGCCGAACACGAAATGGCCGCACACGCGTGA

Structures

Toxin

• AlphaFold DB: A0A6P2QRH5