Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1881894..1882471 Replicon chromosome
Accession NZ_CP013377
Organism Burkholderia pseudomultivorans strain SUB-INT23-BP2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag WS57_RS07965 Protein ID WP_009688133.1
Coordinates 1882106..1882471 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag WS57_RS07960 Protein ID WP_009688134.1
Coordinates 1881894..1882112 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WS57_RS07940 1877591..1878859 - 1269 WP_059477428.1 Zn-dependent hydrolase -
WS57_RS07945 1878852..1879388 - 537 WP_009688137.1 L-2-amino-thiazoline-4-carboxylic acid hydrolase -
WS57_RS07950 1879559..1880725 - 1167 WP_069244007.1 branched-chain amino acid ABC transporter substrate-binding protein -
WS57_RS07955 1880902..1881798 + 897 WP_060249913.1 LysR family transcriptional regulator -
WS57_RS07960 1881894..1882112 + 219 WP_009688134.1 ribbon-helix-helix protein, CopG family Antitoxin
WS57_RS07965 1882106..1882471 + 366 WP_009688133.1 type II toxin-antitoxin system VapC family toxin Toxin
WS57_RS07970 1882522..1882956 - 435 WP_009688132.1 GNAT family N-acetyltransferase -
WS57_RS07975 1883212..1883775 + 564 WP_009688131.1 peroxiredoxin -
WS57_RS07980 1883888..1885486 + 1599 WP_069244008.1 alkyl hydroperoxide reductase subunit F -
WS57_RS07985 1885590..1886369 - 780 WP_069244009.1 extensin -
WS57_RS07990 1886509..1887408 - 900 WP_059477424.1 lipid A hydroxylase LpxO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-106)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-40)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13434.47 Da        Isoelectric Point: 5.1467

>T58550 WP_009688133.1 NZ_CP013377:1882106-1882471 [Burkholderia pseudomultivorans]
MVKALFDTNILIDYLGGVESARLELGRYDYRAISTITWMEVLVGTTADDEGPIRAWLSSFDVIPLDGTVAGRAVTIRKER
RIRLPDAIVWASAQVNGLLLVSRNTKDFPATEPGIRVPYQV

Download         Length: 366 bp

>T58550 NZ_CP013377:1882106-1882471 [Burkholderia pseudomultivorans]
ATGGTAAAAGCTCTCTTCGACACCAACATCCTGATCGACTACCTGGGCGGCGTGGAATCCGCCCGCCTGGAACTCGGCCG
CTACGACTATCGTGCGATCAGCACCATTACGTGGATGGAAGTTCTGGTCGGTACGACCGCAGATGACGAAGGCCCGATCC
GCGCGTGGCTCTCGTCATTCGACGTGATCCCGCTCGACGGTACGGTTGCCGGCCGCGCTGTGACCATTCGCAAGGAGCGC
CGCATTCGCCTGCCGGACGCGATCGTCTGGGCATCGGCCCAGGTAAACGGGCTGCTGCTCGTGTCGCGTAACACGAAGGA
CTTTCCGGCAACGGAACCCGGCATCCGGGTGCCTTATCAGGTCTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8244.42 Da        Isoelectric Point: 5.0481

>AT58550 WP_009688134.1 NZ_CP013377:1881894-1882112 [Burkholderia pseudomultivorans]
MGRILVDLSDGQLDELAVIVETEHRPRAAIIRDAINAYIALHKRPLADDVFGLWKDRTVDGLAYQEKLRSEW

Download         Length: 219 bp

>AT58550 NZ_CP013377:1881894-1882112 [Burkholderia pseudomultivorans]
ATGGGCCGAATTCTGGTGGATCTGTCAGACGGCCAGCTCGACGAGCTGGCCGTCATCGTCGAGACTGAGCATCGCCCTCG
CGCCGCGATCATTCGCGATGCGATCAATGCCTACATTGCTCTACACAAGCGCCCGCTCGCCGACGACGTCTTCGGTCTCT
GGAAAGATCGCACCGTCGACGGGCTCGCTTATCAGGAAAAACTGCGCTCGGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References