Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1125790..1127528 Replicon chromosome
Accession NZ_CP013377
Organism Burkholderia pseudomultivorans strain SUB-INT23-BP2

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag WS57_RS04785 Protein ID WP_069243812.1
Coordinates 1125790..1126677 (+) Length 296 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A132F6R9
Locus tag WS57_RS04790 Protein ID WP_040131503.1
Coordinates 1126674..1127528 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WS57_RS04755 1121191..1122270 - 1080 WP_040131495.1 porin -
WS57_RS04760 1122705..1123022 + 318 WP_006396774.1 non-heme iron oxygenase ferredoxin subunit -
WS57_RS04765 1123024..1123335 + 312 WP_009692515.1 hypothetical protein -
WS57_RS04770 1123382..1124452 + 1071 WP_009692516.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
WS57_RS04775 1124445..1125215 + 771 WP_069243811.1 SDR family oxidoreductase -
WS57_RS04780 1125244..1125771 + 528 WP_009692519.1 cupin domain-containing protein -
WS57_RS04785 1125790..1126677 + 888 WP_069243812.1 alpha/beta fold hydrolase Toxin
WS57_RS04790 1126674..1127528 + 855 WP_040131503.1 IclR family transcriptional regulator Antitoxin
WS57_RS04795 1127525..1128322 + 798 WP_059517485.1 SDR family oxidoreductase -
WS57_RS04800 1128315..1129982 + 1668 WP_059604101.1 thiamine pyrophosphate-binding protein -
WS57_RS04805 1129975..1130802 + 828 WP_040131509.1 aspartate dehydrogenase -
WS57_RS04810 1130880..1132370 + 1491 WP_069243813.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(48-276)

Antitoxin

Transcription regulator IclR, C-terminal

(142-265)


Sequences

Toxin        


Download         Length: 296 a.a.        Molecular weight: 30396.65 Da        Isoelectric Point: 7.9595

>T58547 WP_069243812.1 NZ_CP013377:1125790-1126677 [Burkholderia pseudomultivorans]
MSVVEKRERDRFATLLGQFPEQRCAAGAAGTIGYREAGAQQAGRTLPVVLLHGIGSGAASWVCQLDALGASRRVLAWDAP
GYGVSTPVNGASPAAADYAASLNAWLDALGIERCVLVGHSLGAIVAGGLARVMPARIAGLLLISPAGGYGSAPAETRESR
RDARLAMLAELGPEGLAAQRSGNMLSGFASEDARAWVRWNMARIVPAGYAQATHLLANADLATDLAGFRGRTAVAVGAND
AITPPAACERIAAAARVGLQVIPQAGHAGYVEAPAVYSALIDAFCRQCDRQWGLA

Download         Length: 888 bp

>T58547 NZ_CP013377:1125790-1126677 [Burkholderia pseudomultivorans]
ATGAGTGTCGTCGAAAAACGTGAGCGCGACCGGTTCGCGACGCTGCTCGGGCAGTTTCCCGAGCAGCGCTGCGCGGCCGG
TGCGGCGGGCACGATCGGATACCGCGAGGCCGGCGCGCAACAGGCCGGCCGCACGCTGCCCGTCGTGCTGCTGCACGGGA
TCGGCTCGGGCGCCGCGTCGTGGGTGTGCCAGCTCGATGCGCTCGGCGCGTCGCGCCGCGTGCTCGCGTGGGATGCGCCC
GGCTACGGCGTATCGACGCCCGTGAACGGCGCGTCGCCGGCCGCCGCCGATTACGCGGCGTCGCTGAACGCGTGGCTCGA
CGCACTCGGCATCGAACGCTGCGTGCTGGTCGGGCATTCGCTCGGCGCGATCGTCGCGGGCGGCCTGGCCCGCGTGATGC
CCGCGCGGATCGCCGGCCTGCTGCTGATCTCGCCCGCGGGCGGCTACGGCAGTGCGCCCGCCGAAACGCGCGAATCGCGC
CGCGACGCGCGCCTCGCGATGCTCGCGGAGCTCGGCCCGGAAGGGCTCGCAGCGCAGCGCAGCGGCAACATGCTGTCGGG
CTTCGCGAGCGAGGATGCACGTGCATGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTATGCGCAGGCCACGC
ACCTGCTCGCGAACGCAGATCTCGCGACCGATCTCGCCGGCTTTCGCGGCCGCACGGCGGTGGCGGTCGGCGCGAACGAC
GCGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCCGCGGCCGCGCGGGTCGGGCTGCAGGTGATTCCGCAGGCCGGCCA
CGCCGGCTACGTGGAAGCGCCGGCCGTCTATTCCGCGCTGATCGACGCGTTCTGTCGTCAGTGCGACCGGCAGTGGGGGC
TGGCATGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31259.86 Da        Isoelectric Point: 6.6572

>AT58547 WP_040131503.1 NZ_CP013377:1126674-1127528 [Burkholderia pseudomultivorans]
MSEPLQKEVEGAKSEANYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVLESLRDATGFTTHIVIRDGRDVVFVAKAQSQAAVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLKELRALYPEGVLPRMTSATPETVEALYEVIREDALRGYGVSNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDDALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 855 bp

>AT58547 NZ_CP013377:1126674-1127528 [Burkholderia pseudomultivorans]
ATGAGCGAACCGCTGCAAAAGGAAGTGGAAGGCGCGAAGAGCGAGGCCAACTACGTGGTGCCGGGCCTCGAGCGCGGCTT
GCGGATCCTCGCCGAATTCTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAACTGTCGAAGCGGCTCGGGATTCCGCGCA
CGACGGTGTTCCGTCTGCTGCAGACGCTGGAATCGCTCGGCTTTCTCGAACGTGCGGACAAGGATCGCAACTACAAACTC
GGCATCGCGGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCGGTGCTCGAAAG
CCTGCGCGACGCGACCGGCTTCACGACGCATATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGCAGA
GCCAGGCGGCGGTGTTCAGCTCCATTCGCGTGAACGTCGGCACGCGGCTGCCTGCGCATGCGACGACGCACGGCCACGTG
CTGATGGGCGACCTGTCGCTGAAGGAACTGCGCGCGCTGTATCCGGAAGGCGTGCTGCCGCGGATGACGAGCGCGACGCC
GGAAACGGTCGAGGCGCTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCGAGC
GCGGCATCTCGGTCGTCACGGCGCCGGTGCGCAACGACACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCGCGT
CCGGAGATCGACGACGCGCTGATCGCGGACGGATTGATCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGAAGACT
CAATTATCGCTCGGATGACGAGCACACGTTTCTCAAGGCTTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A132F6R9

References