Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 317173..317768 Replicon chromosome
Accession NZ_CP013377
Organism Burkholderia pseudomultivorans strain SUB-INT23-BP2

Toxin (Protein)


Gene name chpB Uniprot ID A0A132EL24
Locus tag WS57_RS01375 Protein ID WP_009693107.1
Coordinates 317173..317523 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID B9B2F5
Locus tag WS57_RS01380 Protein ID WP_006397258.1
Coordinates 317517..317768 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WS57_RS01365 312257..315457 + 3201 WP_060300970.1 multidrug efflux RND transporter permease subunit CeoB -
WS57_RS01370 315468..317003 + 1536 WP_059519271.1 multidrug efflux transporter outer membrane subunit OpcM -
WS57_RS01375 317173..317523 - 351 WP_009693107.1 type II toxin-antitoxin system ChpB family toxin Toxin
WS57_RS01380 317517..317768 - 252 WP_006397258.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
WS57_RS01385 318088..319581 - 1494 WP_069243643.1 M81 family metallopeptidase -
WS57_RS01390 319682..320986 - 1305 WP_059519276.1 MFS transporter -
WS57_RS01395 321128..322099 + 972 WP_059519278.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12414.43 Da        Isoelectric Point: 8.8909

>T58545 WP_009693107.1 NZ_CP013377:c317523-317173 [Burkholderia pseudomultivorans]
MVKRVKFERGDIVRVSLNPTLGREQQGDFRPALVLSPAAFNALGVALVAPITQGGEFARFAGFAVPLSGAGTETQGVALV
NMVRMLDLEARGARKVERAPVEVVEDALARLQTIIE

Download         Length: 351 bp

>T58545 NZ_CP013377:c317523-317173 [Burkholderia pseudomultivorans]
ATGGTGAAGCGCGTCAAGTTCGAGCGAGGCGATATCGTGCGCGTGAGCCTGAATCCGACTCTCGGTCGTGAGCAGCAGGG
CGACTTTCGTCCGGCGCTGGTGCTCTCCCCGGCAGCGTTCAACGCTTTGGGCGTTGCGCTGGTCGCACCGATCACCCAGG
GTGGCGAATTTGCCCGGTTCGCAGGGTTCGCGGTCCCGCTGTCCGGTGCAGGAACCGAGACGCAGGGCGTCGCACTGGTG
AACATGGTTCGCATGCTCGACCTGGAGGCGCGCGGCGCTCGCAAGGTCGAACGCGCGCCTGTCGAGGTCGTGGAAGATGC
ACTCGCCCGGCTTCAGACGATCATCGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9007.36 Da        Isoelectric Point: 6.2420

>AT58545 WP_006397258.1 NZ_CP013377:c317768-317517 [Burkholderia pseudomultivorans]
MELKIQKWGNSAAVRLPSVLLEQINATVGSSLSADVRPDGVLLTPARRKYSLDDLVAQCDTKAPFPADMAAWGEVKPVGR
EAW

Download         Length: 252 bp

>AT58545 NZ_CP013377:c317768-317517 [Burkholderia pseudomultivorans]
ATGGAACTCAAGATTCAAAAATGGGGCAATAGCGCGGCGGTTCGTTTGCCCAGCGTTCTGCTCGAACAGATCAACGCGAC
GGTCGGCAGTTCGCTGAGCGCGGACGTGCGCCCGGATGGCGTGTTGTTGACGCCGGCCCGCCGCAAGTATTCGCTCGATG
ATCTCGTTGCCCAATGCGACACGAAAGCGCCTTTCCCTGCCGACATGGCTGCATGGGGCGAGGTCAAGCCGGTGGGGCGT
GAGGCATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A132EL24

Antitoxin

Source ID Structure
AlphaFold DB A0A132EKI4

References