Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2369455..2371205 Replicon chromosome
Accession NZ_CP013376
Organism Burkholderia cepacia strain INT3-BP177

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag WI67_RS27120 Protein ID WP_059484803.1
Coordinates 2370309..2371205 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag WI67_RS27115 Protein ID WP_069254756.1
Coordinates 2369455..2370312 (-) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WI67_RS27095 2364618..2366108 - 1491 WP_069254755.1 aldehyde dehydrogenase -
WI67_RS27100 2366181..2367008 - 828 WP_021161508.1 aspartate dehydrogenase -
WI67_RS27105 2367001..2368668 - 1668 WP_021161509.1 thiamine pyrophosphate-binding protein -
WI67_RS27110 2368661..2369458 - 798 WP_059484804.1 SDR family oxidoreductase -
WI67_RS27115 2369455..2370312 - 858 WP_069254756.1 IclR family transcriptional regulator Antitoxin
WI67_RS27120 2370309..2371205 - 897 WP_059484803.1 alpha/beta fold hydrolase Toxin
WI67_RS27125 2371224..2371751 - 528 WP_021161513.1 cupin domain-containing protein -
WI67_RS27130 2371785..2372555 - 771 WP_069254757.1 SDR family oxidoreductase -
WI67_RS27135 2372548..2373618 - 1071 WP_021161515.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
WI67_RS27140 2373661..2373972 - 312 WP_021161516.1 hypothetical protein -
WI67_RS27145 2373976..2374293 - 318 WP_021161517.1 non-heme iron oxygenase ferredoxin subunit -
WI67_RS34585 2374388..2374714 - 327 WP_155771179.1 hypothetical protein -
WI67_RS27150 2374739..2375818 + 1080 WP_042976372.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, C-terminal

(143-266)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30609.79 Da        Isoelectric Point: 7.7327

>T58541 WP_059484803.1 NZ_CP013376:c2371205-2370309 [Burkholderia cepacia]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVSQFDTLGASRRVLAW
DAPGYGVSTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIVAGGLARVMPARIAGLLLVSPAGGYGSAPAETR
ESRRDARLAMLAELGPAGLAEQRSGNMLSGFANEEARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDSFCRQCDQQRGLA

Download         Length: 897 bp

>T58541 NZ_CP013376:c2371205-2370309 [Burkholderia cepacia]
ATGAGTGTCATCGACAAACGCGAGCGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTTCCCGAGCAGCGTTG
CGCGGCCGGCGCGGCGGGCACGATTGGTTACCGTGAGGCCGGCGCGCAGCATGCGGGCCGCGCGCTGCCCGTCGTGCTGC
TGCACGGCATCGGCTCGGGCGCCGCATCGTGGGTCAGCCAGTTCGACACGCTCGGCGCATCGCGGCGCGTGCTCGCGTGG
GACGCGCCCGGTTACGGCGTGTCGACGCCCGTGCACGGCGCGTCGCCGGCCGCCGCCGATTACGCGGCATCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGTGTGCTGGTCGGCCATTCGCTCGGCGCGATCGTCGCGGGCGGTCTCGCCC
GCGTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGGTGTCGCCCGCGGGCGGCTACGGCAGCGCACCGGCCGAAACGCGT
GAATCGCGCCGCGACGCGCGGCTCGCGATGCTCGCCGAACTCGGCCCGGCCGGGCTCGCCGAACAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGAACGAGGAGGCACGTGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTATGCGC
AGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGGCCGATCTCGCCGGCTTTCGCGGCCGCACGGCCGTGGCCGTCGGT
GCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCCGCGGCTGCGCACGTCGGGCTGCAGGTGATTCCGCA
AGCCGGTCATGCCGGTTATGTCGAGGCGCCGGCCGTCTATTCCGCGCTGATCGACTCGTTCTGCCGTCAGTGCGACCAAC
AGCGGGGGCTGGCATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31615.19 Da        Isoelectric Point: 6.9868

>AT58541 WP_069254756.1 NZ_CP013376:c2370312-2369455 [Burkholderia cepacia]
MNEPLRRPEPENDKAEANYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELRTLYPEGTLNRMTNATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFMKALGLR

Download         Length: 858 bp

>AT58541 NZ_CP013376:c2370312-2369455 [Burkholderia cepacia]
ATGAACGAACCGCTGCGACGACCCGAACCCGAAAACGACAAGGCCGAAGCCAACTACGTGGTGCCCGGCCTCGAACGCGG
GCTGCGAATCCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGTGCGCCGGAGCTGTCGAAGCGGCTCGGCATTCCGC
GCACGACGGTGTTCCGCCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGCGCGGACAAGGATCGCAACTACAAG
CTCGGCATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCCGTGATCGA
GAGCCTGCGCGACGCCACCGGCTTCACGACGCACATCGTGATCCGTGATGGCCGAGACGTGGTGTTCGTCGCGAAAGCGC
AGAGCCAGTCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGCACGCGCTTGCCCGCGCATGCGACGACGCACGGCCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAGCTGCGCACGCTGTATCCGGAAGGCACGCTGAACCGGATGACGAACGCGAC
ACCGGAAACGGTCGACGCGCTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGCATCTCGGTGGTCACGGCGCCGGTGCGCAACGAGACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGGCCGGAGATCGACGCGGCGCTGATCGCGGACGGGCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGACGACGAGCACACGTTTATGAAAGCATTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References