Detailed information of TA system TA058537

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 1852294..1852967
• Replicon: chromosome
• Accession: NZ_CP013375
• Organism: Burkholderia cepacia strain INT3-BP177

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: U2G353
• Locus tag: WI67_RS08220
• Protein ID: WP_021160096.1
• Coordinates: 1852551..1852967 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: U2FLJ7
• Locus tag: WI67_RS08215
• Protein ID: WP_021160097.1
• Coordinates: 1852294..1852554 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WI67_RS08200	1847849..1850101	+	2253	WP_069253455.1	TonB-dependent siderophore receptor	-
WI67_RS08205	1850188..1851027	+	840	WP_069253919.1	N(5)-hydroxyornithine transformylase PvdF	-
WI67_RS08210	1851027..1852043	+	1017	WP_059484567.1	acetyltransferase	-
WI67_RS08215	1852294..1852554	+	261	WP_021160097.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
WI67_RS08220	1852551..1852967	+	417	WP_021160096.1	PIN domain-containing protein	Toxin
WI67_RS08225	1853016..1853921	-	906	WP_069253456.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
WI67_RS08230	1853890..1854963	-	1074	WP_059588220.1	hypothetical protein	-
WI67_RS08235	1855305..1856468	+	1164	WP_027787433.1	amidohydrolase	-
WI67_RS08240	1856712..1857251	+	540	WP_069253457.1	outer membrane protein assembly factor BamE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-130)

Antitoxin

• SpoVT-AbrB domain (7-54)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 14566.75 Da
• Isoelectric Point: 7.8895

>T58537 WP_021160096.1 NZ_CP013375:1852551-1852967 [Burkholderia cepacia]
VTTLYMLDTNICSFIMRERPPVVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGRKASPKHAELVTAFVSRLDGVLSWDTA
AVDATAAIRADLAARGMPIGANDASIAGHAIAAGAVLVTNNGREFGRVAGLSLEDWAA

Nucleotide

• Length: 417 bp

>T58537 NZ_CP013375:1852551-1852967 [Burkholderia cepacia]
GTGACCACGCTCTACATGCTCGATACGAACATCTGTTCGTTCATCATGCGCGAGCGGCCGCCGGTAGTGCTGTCGCGGCT
GCAATCGTGCGTCAATGCGCAGCACCGGATCGTCGTGTCGGCCATCACTTATGCCGAAATGCGGTTCGGTGCAGTCGGCA
GGAAGGCTTCGCCGAAGCATGCGGAACTCGTGACGGCCTTTGTCTCGCGGCTCGATGGGGTGCTGTCGTGGGATACGGCG
GCCGTCGATGCAACGGCCGCGATTCGTGCCGATCTCGCCGCGCGCGGCATGCCGATCGGCGCGAACGATGCGTCGATCGC
CGGGCATGCGATCGCGGCCGGTGCGGTGCTCGTCACGAACAACGGCCGGGAGTTCGGCCGGGTGGCCGGGTTGTCGCTCG
AAGACTGGGCAGCCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9546.80 Da
• Isoelectric Point: 4.6151

>AT58537 WP_021160097.1 NZ_CP013375:1852294-1852554 [Burkholderia cepacia]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWLSFASEPLADADFLAERPAVIESGRFDLSGGAA
PTESGQ

Nucleotide

• Length: 261 bp

>AT58537 NZ_CP013375:1852294-1852554 [Burkholderia cepacia]
ATGCGCACCGTTTCCATTTTCAAGAACGCCCGTAACCAGGCAATCCGCATCCCGAAGGACATGGAGTTCGAGGGGGTGAC
GGAACTCGAGATCCGTCGCGAGGGCGACACGCTGCTGCTGCGGCCCGTGCGGCCCACGTGGCTCTCGTTCGCGAGCGAAC
CGCTGGCCGACGCCGATTTCCTCGCCGAACGCCCGGCCGTGATCGAGTCCGGCCGCTTCGACCTTTCCGGCGGCGCCGCG
CCGACGGAGTCCGGCCAGTGA

Structures

Toxin

• AlphaFold DB: U2G353

Antitoxin

• AlphaFold DB: U2FLJ7