Detailed information of TA system TA058536

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 200157..200794
• Replicon: chromosome
• Accession: NZ_CP013375
• Organism: Burkholderia cepacia strain INT3-BP177

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: WI67_RS00805
• Protein ID: WP_069253124.1
• Coordinates: 200393..200794 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: WI67_RS00800
• Protein ID: WP_069253890.1
• Coordinates: 200157..200393 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WI67_RS00785	195641..196672	+	1032	WP_042978041.1	helix-turn-helix domain-containing protein	-
WI67_RS00790	196931..198043	-	1113	WP_069253123.1	ADP-heptose--LPS heptosyltransferase	-
WI67_RS00795	198040..199743	-	1704	WP_059678233.1	thiamine pyrophosphate-binding protein	-
WI67_RS00800	200157..200393	+	237	WP_069253890.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
WI67_RS00805	200393..200794	+	402	WP_069253124.1	type II toxin-antitoxin system VapC family toxin	Toxin
WI67_RS00810	200860..202248	-	1389	WP_021164187.1	L-serine ammonia-lyase	-
WI67_RS00815	202279..203415	-	1137	WP_059490381.1	alginate lyase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-121)

Antitoxin

• SpoVT-AbrB domain (7-46)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15042.15 Da
• Isoelectric Point: 5.6087

>T58536 WP_069253124.1 NZ_CP013375:200393-200794 [Burkholderia cepacia]
MPRYMLDTNMCIYLMKHQPEQVAKRFAQCYTGDVVMSAITYAELEYGVAACANAVRERRNLADLIEDIPVAPFDAAAAHA
YGPVREATRERKRDHLDKLIAAHAVSLDVVLVTNNERDFASYPGLRLENWLND

Nucleotide

• Length: 402 bp

>T58536 NZ_CP013375:200393-200794 [Burkholderia cepacia]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTATTTGATGAAGCATCAGCCGGAACAGGTCGCGAAACGATTTGC
CCAGTGCTACACGGGGGACGTCGTGATGTCGGCGATTACCTACGCCGAGCTCGAATACGGCGTGGCCGCGTGTGCGAATG
CCGTCCGGGAGCGCCGCAACCTTGCCGACCTGATCGAGGATATTCCGGTTGCGCCGTTCGACGCGGCGGCCGCGCATGCG
TACGGCCCTGTTCGCGAAGCGACCCGCGAGCGGAAGAGGGATCATCTCGACAAACTGATCGCGGCGCACGCGGTGTCGCT
CGACGTCGTGCTCGTGACCAACAACGAGCGGGATTTCGCGAGTTACCCGGGGTTGCGGCTGGAGAACTGGCTGAACGACT
AG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8967.13 Da
• Isoelectric Point: 5.7252

>AT58536 WP_069253890.1 NZ_CP013375:200157-200393 [Burkholderia cepacia]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERIGDEIRIRPMRRPLAGVLEKFAKFAPDFMAEGRGDHEQADREGL

Nucleotide

• Length: 237 bp

>AT58536 NZ_CP013375:200157-200393 [Burkholderia cepacia]
ATGCATACCACGAGGGTGTTCCGGAACGGCAACTCGCAGGCCGTACGGATTCCGGCGGACCTTGCCTACGAGCGCAGCGA
TATCGAGCTCGAAATCGAACGGATCGGCGACGAAATCCGTATTCGTCCCATGCGACGGCCGTTGGCTGGCGTGCTCGAGA
AGTTCGCGAAATTCGCGCCGGATTTCATGGCTGAAGGGCGTGGCGACCACGAGCAGGCCGACCGCGAGGGTTTGTGA