Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 177248..177918 Replicon chromosome
Accession NZ_CP013374
Organism Burkholderia sp. NRF60-BP8

Toxin (Protein)


Gene name relE Uniprot ID A0A807ERN5
Locus tag WS54_RS30445 Protein ID WP_059779944.1
Coordinates 177248..177544 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A807ETE5
Locus tag WS54_RS30450 Protein ID WP_059779943.1
Coordinates 177547..177918 (+) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WS54_RS30420 173144..173920 + 777 WP_059779948.1 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase -
WS54_RS30425 174029..174427 + 399 WP_059779947.1 RidA family protein -
WS54_RS30430 174639..174809 + 171 Protein_158 porin -
WS54_RS30435 174940..176787 + 1848 WP_059780004.1 tannase/feruloyl esterase family alpha/beta hydrolase -
WS54_RS30440 176899..177096 + 198 Protein_160 TolC family protein -
WS54_RS30445 177248..177544 + 297 WP_059779944.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WS54_RS30450 177547..177918 + 372 WP_059779943.1 putative addiction module antidote protein Antitoxin
WS54_RS30455 178013..179623 - 1611 WP_059779942.1 cytochrome c -
WS54_RS30460 179614..180015 - 402 WP_059779941.1 hypothetical protein -
WS54_RS30465 180012..182651 - 2640 WP_059779940.1 cytochrome c oxidase subunit I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(5-92)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10833.62 Da        Isoelectric Point: 10.1723

>T58534 WP_059779944.1 NZ_CP013374:177248-177544 [Burkholderia sp. NRF60-BP8]
MFKVLTTPQFDKWLDGLRDPVGSAAISLRIERAKLGNLGQWRAIGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKTAKQIAAELED

Download         Length: 297 bp

>T58534 NZ_CP013374:177248-177544 [Burkholderia sp. NRF60-BP8]
ATGTTCAAAGTCCTGACCACTCCCCAATTTGACAAATGGCTCGATGGTCTTCGCGACCCGGTCGGCAGCGCCGCGATCAG
CCTACGCATCGAGCGGGCGAAGCTCGGCAATCTTGGCCAGTGGCGTGCGATCGGCGACGGCGTCAACGAAATGAAGATCG
ATGTAGGGCCGGGGTACCGGGCCTACTTCGTGCGACGCGGAAAGATAATCGTCGTGGTGTTGTGTGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGACGGCGAAGCAAATCGCCGCCGAACTGGAGGATTGA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13076.87 Da        Isoelectric Point: 8.5337

>AT58534 WP_059779943.1 NZ_CP013374:177547-177918 [Burkholderia sp. NRF60-BP8]
MKISELAEFDGAKYLKDEEAIRHYLAQAFEDGDPRLIQVALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVAALGLHLTVAPTTQTAEAAAAPEPTSRTRSRSPARAVAHG

Download         Length: 372 bp

>AT58534 NZ_CP013374:177547-177918 [Burkholderia sp. NRF60-BP8]
ATGAAAATCAGCGAACTGGCCGAATTCGACGGCGCAAAGTACCTGAAGGACGAGGAAGCGATTCGTCACTACCTGGCGCA
GGCGTTCGAAGATGGGGATCCTCGACTGATCCAGGTCGCGCTCGGAAACGTCGCGAAGGCGCGTGGCATGACGGCGCTGG
CGCGCGAGTCCGGTGTGAAGCGTGAAGCGCTCTACCGTGCGCTGTCGGAAGGTGGGAACGCGGAGTTTGCAACGATCATG
AAGGTGGTCGCCGCGTTGGGATTGCATCTGACCGTTGCGCCGACCACGCAGACCGCCGAAGCGGCAGCCGCGCCTGAACC
GACCTCGCGCACGCGTTCGCGTTCGCCAGCACGGGCGGTGGCCCACGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A807ERN5

Antitoxin

Source ID Structure
AlphaFold DB A0A807ETE5

References