Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/Tad-HTH_37
Location 2543617..2544299 Replicon chromosome
Accession NZ_CP013373
Organism Burkholderia sp. NRF60-BP8

Toxin (Protein)


Gene name tad Uniprot ID A0A807ENX5
Locus tag WS54_RS25290 Protein ID WP_059781257.1
Coordinates 2543617..2543979 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A807EMQ7
Locus tag WS54_RS25295 Protein ID WP_059781255.1
Coordinates 2543976..2544299 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WS54_RS25265 2539446..2539901 + 456 WP_034208039.1 VOC family protein -
WS54_RS25270 2539994..2541544 - 1551 WP_059499177.1 sodium:solute symporter family protein -
WS54_RS25275 2541541..2541783 - 243 WP_059781260.1 DUF3311 domain-containing protein -
WS54_RS25280 2541983..2542900 - 918 WP_059781258.1 hypothetical protein -
WS54_RS25285 2543047..2543301 + 255 WP_034208041.1 hypothetical protein -
WS54_RS25290 2543617..2543979 + 363 WP_059781257.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WS54_RS25295 2543976..2544299 + 324 WP_059781255.1 helix-turn-helix domain-containing protein Antitoxin
WS54_RS25300 2544364..2544840 - 477 WP_059781253.1 DNA-deoxyinosine glycosylase -
WS54_RS25305 2544840..2545436 - 597 WP_059781369.1 chorismate lyase -
WS54_RS25310 2545445..2547343 - 1899 WP_059781251.1 molecular chaperone HtpG -
WS54_RS25315 2547502..2548962 - 1461 WP_034208046.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(30-85)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13314.18 Da        Isoelectric Point: 10.0982

>T58533 WP_059781257.1 NZ_CP013373:2543617-2543979 [Burkholderia sp. NRF60-BP8]
MDPYIKPLYWLGSARKDLKAMPEAVQDTFGYALYPAQTGRRHDRAKPLRGFGSAGVLEIVESEDNGTYRAIYTVKLGGSV
YVLHCFQKKSSSGVATPRPDSDLVRERLKAAKAHATGERR

Download         Length: 363 bp

>T58533 NZ_CP013373:2543617-2543979 [Burkholderia sp. NRF60-BP8]
ATGGATCCATACATCAAACCGCTGTACTGGCTCGGCTCGGCGCGCAAGGACTTGAAAGCGATGCCCGAAGCCGTGCAGGA
CACGTTCGGTTATGCGCTGTATCCGGCGCAGACGGGACGCAGGCACGATCGGGCCAAGCCCTTGAGGGGATTCGGATCGG
CAGGCGTGCTGGAGATCGTGGAATCGGAAGACAACGGCACGTACCGCGCAATCTACACGGTGAAGCTGGGCGGCAGCGTC
TACGTGCTGCACTGTTTCCAGAAGAAATCGTCGAGCGGCGTCGCGACACCCAGGCCGGACAGCGACCTCGTCCGCGAACG
TCTGAAAGCGGCCAAAGCACACGCAACAGGAGAAAGGCGATGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11781.76 Da        Isoelectric Point: 9.8320

>AT58533 WP_059781255.1 NZ_CP013373:2543976-2544299 [Burkholderia sp. NRF60-BP8]
MIEIEPASGNVYADLGMRDADEMRVKAQLAAKIAEIIKARKWTQQHAARLLGIPQPKLSNMLRGQFRGVSETKMLECLAK
LGRDVQIVVGPDRRSEAAGHIEVVFAA

Download         Length: 324 bp

>AT58533 NZ_CP013373:2543976-2544299 [Burkholderia sp. NRF60-BP8]
ATGATCGAAATCGAACCGGCCAGCGGGAACGTCTACGCTGACCTGGGCATGCGCGATGCCGACGAAATGCGGGTGAAGGC
CCAGCTCGCCGCGAAGATCGCGGAAATCATCAAGGCGCGCAAATGGACGCAGCAGCACGCGGCACGATTGCTCGGCATCC
CTCAGCCGAAGCTGTCGAACATGTTGCGCGGTCAGTTTCGCGGCGTGAGCGAGACAAAGATGCTCGAATGTCTCGCCAAG
CTCGGACGCGACGTGCAGATCGTCGTCGGGCCGGACCGCCGGTCGGAAGCCGCAGGACACATCGAAGTCGTTTTCGCCGC
CTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A807ENX5

Antitoxin

Source ID Structure
AlphaFold DB A0A807EMQ7

References