Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1753583..1754265 Replicon chromosome
Accession NZ_CP013373
Organism Burkholderia sp. NRF60-BP8

Toxin (Protein)


Gene name vagD Uniprot ID A0A807ELK8
Locus tag WS54_RS21490 Protein ID WP_034207291.1
Coordinates 1753843..1754265 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A807EQ43
Locus tag WS54_RS21485 Protein ID WP_052100282.1
Coordinates 1753583..1753846 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WS54_RS21470 1749145..1751388 + 2244 WP_059785983.1 TonB-dependent siderophore receptor -
WS54_RS21475 1751477..1752316 + 840 WP_034207289.1 N(5)-hydroxyornithine transformylase PvdF -
WS54_RS21480 1752316..1753332 + 1017 WP_059785705.1 acetyltransferase -
WS54_RS21485 1753583..1753846 + 264 WP_052100282.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
WS54_RS21490 1753843..1754265 + 423 WP_034207291.1 PIN domain-containing protein Toxin
WS54_RS21495 1754308..1755213 - 906 WP_059785708.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
WS54_RS21500 1755182..1756255 - 1074 WP_034207293.1 hypothetical protein -
WS54_RS21505 1756600..1757763 + 1164 WP_059785711.1 amidohydrolase -
WS54_RS21510 1757877..1757975 + 99 WP_080747772.1 type II toxin-antitoxin system ParD family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 14676.80 Da        Isoelectric Point: 7.8895

>T58532 WP_034207291.1 NZ_CP013373:1753843-1754265 [Burkholderia sp. NRF60-BP8]
VTTLYMLDTNICSFIMRERPPAVLSRLQSCVNAQHRIVVSAVTYAEMRFGAVGRKASPKHADLVTSFVARLDGVLAWDTA
AIDATAAIRADLAARGTPIGANDASIAGHAIAAGAVLVTNNGREFSRVAGLPLEDWAASA

Download         Length: 423 bp

>T58532 NZ_CP013373:1753843-1754265 [Burkholderia sp. NRF60-BP8]
GTGACCACGCTCTACATGCTCGATACGAACATCTGTTCGTTCATCATGCGCGAGCGGCCGCCCGCGGTGCTGTCGCGGTT
GCAGTCGTGCGTCAACGCGCAGCACCGGATCGTCGTATCGGCCGTTACTTATGCCGAAATGCGGTTCGGTGCAGTCGGCA
GAAAGGCATCGCCGAAGCATGCCGACCTCGTGACGAGCTTTGTCGCGCGGCTGGACGGCGTGCTGGCGTGGGATACCGCG
GCGATCGATGCAACCGCCGCGATTCGCGCCGACCTCGCCGCCCGTGGCACGCCGATCGGCGCGAACGACGCATCGATCGC
CGGCCACGCGATCGCAGCCGGTGCGGTGCTCGTCACGAACAACGGTCGCGAATTCAGTCGTGTCGCGGGGTTGCCGCTCG
AAGACTGGGCGGCCTCGGCATGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9860.12 Da        Isoelectric Point: 4.5112

>AT58532 WP_052100282.1 NZ_CP013373:1753583-1753846 [Burkholderia sp. NRF60-BP8]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWLSFANEPLADADFLAERPAVVETGRFDLSGDAD
VPTESNR

Download         Length: 264 bp

>AT58532 NZ_CP013373:1753583-1753846 [Burkholderia sp. NRF60-BP8]
ATGCGCACCGTTTCCATTTTCAAGAACGCCCGTAACCAGGCAATCCGCATCCCGAAGGACATGGAGTTCGAGGGGGTCAC
CGAACTCGAGATCCGCCGCGAGGGCGATACGCTGCTGTTGCGGCCGGTACGCCCCACGTGGCTGTCGTTCGCGAACGAAC
CGCTGGCCGATGCCGATTTCCTCGCCGAACGCCCGGCCGTCGTCGAAACCGGTCGCTTCGACCTGTCCGGCGACGCCGAT
GTGCCGACGGAGTCGAACCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A807ELK8

Antitoxin

Source ID Structure
AlphaFold DB A0A807EQ43

References