Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 174178..174815 Replicon chromosome
Accession NZ_CP013373
Organism Burkholderia sp. NRF60-BP8

Toxin (Protein)


Gene name vapC Uniprot ID A0A807EHD8
Locus tag WS54_RS13825 Protein ID WP_034209615.1
Coordinates 174414..174815 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A807EQB2
Locus tag WS54_RS13820 Protein ID WP_034209858.1
Coordinates 174178..174414 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WS54_RS13805 169914..170930 + 1017 WP_027783194.1 helix-turn-helix domain-containing protein -
WS54_RS13810 171042..172136 - 1095 WP_059780401.1 hypothetical protein -
WS54_RS13815 172133..173836 - 1704 WP_034209616.1 thiamine pyrophosphate-binding protein -
WS54_RS13820 174178..174414 + 237 WP_034209858.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
WS54_RS13825 174414..174815 + 402 WP_034209615.1 type II toxin-antitoxin system VapC family toxin Toxin
WS54_RS13830 174882..176270 - 1389 WP_059780400.1 L-serine ammonia-lyase -
WS54_RS13835 176301..177443 - 1143 WP_034209613.1 alginate lyase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14997.19 Da        Isoelectric Point: 6.0805

>T58531 WP_034209615.1 NZ_CP013373:174414-174815 [Burkholderia sp. NRF60-BP8]
MPRFMLDTNMCIYLMKHQPEQVAKRFAQCYTGDVVMSAITYAELEYGVTACASPARERRHLAALIEDIPVAPFDAAAAQA
YGPIRDATRERKKDHLDKLIAAHAVSLDVVLVTNNERDFVSYPGLRLENWLND

Download         Length: 402 bp

>T58531 NZ_CP013373:174414-174815 [Burkholderia sp. NRF60-BP8]
ATGCCGCGCTTCATGCTCGACACCAACATGTGCATCTATCTGATGAAGCATCAGCCGGAGCAGGTCGCGAAACGATTCGC
GCAGTGCTACACGGGCGACGTCGTCATGTCGGCGATCACCTATGCGGAGCTCGAGTACGGCGTGACCGCATGTGCGAGTC
CGGCCCGGGAGCGCCGCCATCTCGCCGCATTGATCGAGGATATTCCCGTCGCGCCGTTCGACGCCGCGGCCGCGCAAGCG
TATGGCCCGATCCGCGACGCCACCCGCGAGCGGAAGAAGGATCACCTCGACAAACTGATCGCCGCGCATGCGGTGTCGCT
CGATGTCGTCCTCGTGACCAACAACGAGCGGGATTTCGTCAGCTATCCGGGGCTGCGACTGGAGAACTGGCTGAACGACT
AG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9044.22 Da        Isoelectric Point: 5.8651

>AT58531 WP_034209858.1 NZ_CP013373:174178-174414 [Burkholderia sp. NRF60-BP8]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPMRRPLTQVLQKFAKFGPDFMAEGRGDQEQAEREGL

Download         Length: 237 bp

>AT58531 NZ_CP013373:174178-174414 [Burkholderia sp. NRF60-BP8]
ATGCATACCACGAGGGTATTCAGGAACGGCAACTCGCAGGCCGTGCGAATTCCAGCGGACCTCGCTTATGAACGCAGCGA
CATCGAACTGGAAATCGAGCGCGTCGGGGACGAAATCCGGATTCGGCCGATGCGGCGGCCGCTGACGCAGGTACTGCAGA
AATTCGCGAAATTCGGGCCGGACTTCATGGCCGAAGGGCGCGGCGATCAGGAGCAGGCCGAACGCGAGGGATTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A807EHD8

Antitoxin

Source ID Structure
AlphaFold DB A0A807EQB2

References