Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2636295..2636814 Replicon chromosome
Accession NZ_CP013372
Organism Burkholderia sp. NRF60-BP8

Toxin (Protein)


Gene name relE Uniprot ID A0A807EG39
Locus tag WS54_RS12185 Protein ID WP_059780124.1
Coordinates 2636295..2636576 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A807EGB1
Locus tag WS54_RS12190 Protein ID WP_034205945.1
Coordinates 2636566..2636814 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WS54_RS12165 2631999..2632697 - 699 WP_059780121.1 MgtC/SapB family protein -
WS54_RS12170 2632812..2633921 + 1110 WP_059780122.1 AGE family epimerase/isomerase -
WS54_RS12175 2633894..2635513 - 1620 WP_059780123.1 Tar ligand binding domain-containing protein -
WS54_RS12180 2635795..2636238 + 444 WP_059499490.1 PaaI family thioesterase -
WS54_RS12185 2636295..2636576 - 282 WP_059780124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WS54_RS12190 2636566..2636814 - 249 WP_034205945.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
WS54_RS12195 2636933..2637985 - 1053 WP_059780125.1 CoA transferase -
WS54_RS12200 2638152..2638916 - 765 WP_059780126.1 helix-turn-helix domain-containing protein -
WS54_RS12205 2639051..2639833 + 783 WP_059780127.1 crotonase/enoyl-CoA hydratase family protein -
WS54_RS12210 2639910..2641130 + 1221 WP_059780128.1 CoA transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11033.99 Da        Isoelectric Point: 10.7817

>T58530 WP_059780124.1 NZ_CP013372:c2636576-2636295 [Burkholderia sp. NRF60-BP8]
MTFELAFLEPALKEWRKLDRTIRDQFKARLVERLENPRIPSAKLHGHPDRYKIKLRSIGYRLVYEVRDAEVVVLVVAVGR
RERDAVYLAAMKR

Download         Length: 282 bp

>T58530 NZ_CP013372:c2636576-2636295 [Burkholderia sp. NRF60-BP8]
ATGACCTTTGAGCTCGCCTTTCTCGAACCTGCGTTGAAGGAGTGGAGGAAGCTCGATCGCACCATTCGCGATCAGTTCAA
GGCCAGACTCGTCGAACGGCTCGAGAACCCTCGCATTCCTTCGGCGAAGCTGCACGGTCATCCGGACCGCTACAAGATCA
AGCTGCGCAGTATCGGCTATCGCCTCGTGTACGAAGTGCGCGATGCGGAAGTCGTCGTACTGGTAGTCGCGGTGGGGCGT
CGCGAGCGCGATGCGGTCTATCTCGCCGCGATGAAGCGCTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8963.31 Da        Isoelectric Point: 5.0636

>AT58530 WP_034205945.1 NZ_CP013372:c2636814-2636566 [Burkholderia sp. NRF60-BP8]
MPHTILASVTASVSELKRNPMGTVAAGEGFPVAILNHNEPAFYCIPAKTWEAMVERLEDIEDNVLADSRAKEKAVKVKLN
DL

Download         Length: 249 bp

>AT58530 NZ_CP013372:c2636814-2636566 [Burkholderia sp. NRF60-BP8]
ATGCCCCATACCATCCTGGCTAGCGTGACGGCGAGCGTCTCGGAGCTGAAGCGGAACCCGATGGGAACCGTGGCGGCGGG
AGAGGGGTTCCCGGTCGCGATCCTGAATCACAACGAACCCGCGTTCTATTGCATTCCGGCGAAGACATGGGAGGCGATGG
TCGAACGTCTCGAAGATATCGAAGACAACGTGCTGGCCGACTCGCGCGCCAAGGAGAAAGCCGTCAAGGTCAAGTTGAAT
GACCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A807EG39

Antitoxin

Source ID Structure
AlphaFold DB A0A807EGB1

References