Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2078246..2079472 Replicon chromosome
Accession NZ_CP013372
Organism Burkholderia sp. NRF60-BP8

Toxin (Protein)


Gene name vapC Uniprot ID A0A807EEU7
Locus tag WS54_RS09650 Protein ID WP_059786044.1
Coordinates 2078891..2079472 (+) Length 194 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A807EFL4
Locus tag WS54_RS09645 Protein ID WP_059786043.1
Coordinates 2078246..2078812 (+) Length 189 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WS54_RS09620 2073399..2073881 - 483 WP_034204359.1 cupin domain-containing protein -
WS54_RS09625 2074170..2074805 + 636 WP_059786038.1 cysteine hydrolase -
WS54_RS09630 2075071..2075802 - 732 WP_034204357.1 ribonuclease T2 -
WS54_RS09635 2075929..2076501 - 573 WP_059786041.1 hypothetical protein -
WS54_RS09640 2076596..2077999 - 1404 WP_034204355.1 hypothetical protein -
WS54_RS09645 2078246..2078812 + 567 WP_059786043.1 helix-turn-helix domain-containing protein Antitoxin
WS54_RS09650 2078891..2079472 + 582 WP_059786044.1 HD domain-containing protein Toxin
WS54_RS33850 2080267..2080533 - 267 WP_162499606.1 hypothetical protein -
WS54_RS09655 2080498..2081310 + 813 WP_059786047.1 hypothetical protein -
WS54_RS09660 2081300..2082058 + 759 WP_082725192.1 DsbC family protein -
WS54_RS09665 2082387..2083577 + 1191 WP_059786050.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(5-165)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 194 a.a.        Molecular weight: 21358.03 Da        Isoelectric Point: 5.1206

>T58529 WP_059786044.1 NZ_CP013372:2078891-2079472 [Burkholderia sp. NRF60-BP8]
MNPETIHARLAFLREAERLKDVLRSGYTSAGRPESTAEHSWRLCLMALVFADALPGVDTLKLLKLCVVHDLGEALHGDIP
AVEQDAHPDKSAHERDDLLTLTAPLDRAVRDEIVALWDEYEAAASPEARAAKALDKLETILQHNQGSNPPDFDYAFNLGY
GRRHTDAAPLFRAIREIVDADTQRRIDAGGCRA

Download         Length: 582 bp

>T58529 NZ_CP013372:2078891-2079472 [Burkholderia sp. NRF60-BP8]
ATGAATCCCGAGACGATCCACGCGCGGCTCGCTTTCCTGCGCGAAGCCGAACGCCTGAAGGACGTGCTGCGCAGCGGCTA
CACGTCGGCCGGACGCCCCGAAAGCACGGCAGAGCACAGTTGGCGGCTGTGCCTGATGGCGCTCGTGTTCGCCGACGCGC
TGCCCGGCGTCGACACGCTGAAGCTGCTGAAACTGTGCGTCGTCCACGACCTCGGCGAGGCGCTGCACGGCGACATCCCC
GCGGTCGAGCAGGACGCACACCCCGACAAGAGCGCGCACGAACGCGACGACCTGCTGACGCTGACCGCGCCGCTCGATCG
CGCGGTGCGCGACGAGATCGTCGCGCTATGGGATGAATACGAGGCAGCCGCCTCGCCGGAAGCCCGCGCGGCGAAGGCGC
TCGACAAGCTCGAAACGATCCTGCAGCACAACCAGGGCAGCAATCCGCCCGATTTCGACTATGCGTTCAATCTCGGCTAC
GGGCGTCGCCACACCGACGCCGCGCCGCTGTTCCGCGCGATCCGCGAGATCGTCGATGCCGACACGCAGCGCAGGATCGA
CGCGGGTGGATGCCGCGCGTAA

Antitoxin


Download         Length: 189 a.a.        Molecular weight: 20500.34 Da        Isoelectric Point: 10.1902

>AT58529 WP_059786043.1 NZ_CP013372:2078246-2078812 [Burkholderia sp. NRF60-BP8]
MNASPLHPSSLGPQLKRWRALHRVKQSHAAELFGVAQSTISRWEAGLQQMSPDERATAERLLAARLDSAGDHALARLIAG
SAGRMHLVCDLTHRLLASSPARAAEFSQPLSTLLDTSLWRYATPEIVRMEAALAPLGWHDRAGPPSVEFDTGANASRVVP
IRGSRCRWTRMTLSDGSAVRLVETLDAH

Download         Length: 567 bp

>AT58529 NZ_CP013372:2078246-2078812 [Burkholderia sp. NRF60-BP8]
ATGAATGCCTCACCGCTTCATCCGTCCTCGCTCGGCCCGCAACTCAAACGCTGGCGCGCGCTGCACCGCGTAAAGCAAAG
CCACGCGGCCGAGCTGTTCGGCGTCGCGCAATCGACGATCTCGCGCTGGGAGGCCGGCCTCCAGCAGATGTCGCCCGACG
AGCGCGCGACGGCCGAACGGCTGCTCGCCGCGCGCCTCGATTCCGCCGGCGACCACGCACTCGCGCGGCTGATCGCCGGT
AGCGCGGGCCGCATGCATCTCGTGTGCGATCTCACGCACCGTCTGCTTGCCAGCTCGCCGGCGCGCGCGGCCGAGTTCTC
GCAGCCGCTTTCGACGCTGCTCGACACGTCGCTGTGGCGCTACGCGACGCCGGAAATCGTTCGCATGGAAGCCGCGCTCG
CCCCGCTCGGCTGGCACGACCGCGCGGGGCCGCCGAGCGTCGAGTTCGACACCGGCGCGAACGCGTCGCGCGTCGTGCCG
ATTCGCGGTAGCCGGTGCCGGTGGACACGGATGACGTTGTCGGACGGCTCGGCCGTGCGGCTCGTGGAAACGCTCGACGC
GCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A807EEU7

Antitoxin

Source ID Structure
AlphaFold DB A0A807EFL4

References