Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1770605..1772355 Replicon chromosome
Accession NZ_CP013372
Organism Burkholderia sp. NRF60-BP8

Toxin (Protein)


Gene name doc Uniprot ID A0A807EG32
Locus tag WS54_RS08275 Protein ID WP_059783045.1
Coordinates 1771459..1772355 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A807EEJ6
Locus tag WS54_RS08270 Protein ID WP_059783047.1
Coordinates 1770605..1771462 (-) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WS54_RS08250 1765768..1767258 - 1491 WP_059783054.1 aldehyde dehydrogenase -
WS54_RS08255 1767331..1768158 - 828 WP_059783052.1 aspartate dehydrogenase -
WS54_RS08260 1768151..1769818 - 1668 WP_059783051.1 thiamine pyrophosphate-binding protein -
WS54_RS08265 1769811..1770608 - 798 WP_059783049.1 SDR family oxidoreductase -
WS54_RS08270 1770605..1771462 - 858 WP_059783047.1 IclR family transcriptional regulator Antitoxin
WS54_RS08275 1771459..1772355 - 897 WP_059783045.1 alpha/beta fold hydrolase Toxin
WS54_RS08280 1772374..1772901 - 528 WP_034204576.1 cupin domain-containing protein -
WS54_RS08285 1772936..1773706 - 771 WP_059783042.1 SDR family oxidoreductase -
WS54_RS08290 1773699..1774769 - 1071 WP_059783040.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
WS54_RS08295 1774824..1775135 - 312 WP_059783038.1 hypothetical protein -
WS54_RS08300 1775137..1775454 - 318 WP_006489883.1 non-heme iron oxygenase ferredoxin subunit -
WS54_RS08305 1775890..1776969 + 1080 WP_034204572.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-280)

Antitoxin

Transcription regulator IclR, N-terminal

(24-72)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30703.02 Da        Isoelectric Point: 8.0625

>T58528 WP_059783045.1 NZ_CP013372:c1772355-1771459 [Burkholderia sp. NRF60-BP8]
MRVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIVAGGLVRVMPARIAGLLLISPAGGYGSAPAETR
DTRRDARLAMLAELGPAGLAEQRSGNMLSGFANEEARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRAAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAAYSALIDAFCRQCDTQWGMA

Download         Length: 897 bp

>T58528 NZ_CP013372:c1772355-1771459 [Burkholderia sp. NRF60-BP8]
ATGCGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCCTTCGCCGCGCTGCTCGGGCAGTTTCCCGAGCAGCGTTG
CGCAGCCGGCGCGGCGGGCACGATCGGCTACCGCGAGGCCGGCGCGCAGCATGCGGGCCGCGCGCTACCCGTCGTGCTGC
TGCACGGCATCGGCTCGGGCGCCGCATCGTGGGTCCGCCAGCTCGACACGCTCGGCGCGTCGCGACGCGTGCTTGCGTGG
GATGCGCCCGGTTACGGCGTGTCGACGCCCGTGCACGGCGCGTCGCCGGCCGCCGCCGATTACGCGGCATCGCTGAACGC
ATGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGTCATTCGCTCGGCGCGATCGTCGCGGGCGGGTTGGTCC
GCGTGATGCCCGCGCGCATCGCCGGCCTGCTGCTGATCTCGCCCGCGGGCGGTTACGGCAGCGCACCGGCCGAAACGCGC
GACACGCGCCGCGACGCGCGGCTCGCGATGCTCGCGGAACTCGGCCCGGCCGGGCTCGCCGAGCAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGAACGAGGAGGCACGGGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTACGCGC
AGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGGCCGATCTCGCCGGCTTCCGCGGCCGCGCGGCGGTGGCCGTCGGC
GCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCCGCGGCCGCGCACGTCGGGCTGCAGGTGATTCCGCA
GGCCGGGCACGCGGGTTACGTGGAGGCGCCGGCCGCTTATTCGGCGCTGATCGATGCGTTCTGCCGTCAGTGCGATACGC
AGTGGGGAATGGCATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31292.81 Da        Isoelectric Point: 7.4212

>AT58528 WP_059783047.1 NZ_CP013372:c1771462-1770605 [Burkholderia sp. NRF60-BP8]
MSEPLQRNASESAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGVAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELRALYPEGALSRMTSATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQRIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT58528 NZ_CP013372:c1771462-1770605 [Burkholderia sp. NRF60-BP8]
ATGAGCGAACCGCTGCAACGAAACGCATCCGAAAGCGCGAAGGCCGAAGCCAGCTACGTGGTGCCGGGCCTCGAGCGCGG
GCTGCGCATTCTCGCCGAATTCTCGCCGCGCGAGCCGGTGCTCGGCGCGCCCGAGTTGTCGAAGCGGCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGCGCGGACAAGGATCGCAACTACAAG
CTCGGCGTCGCCGTGCTGCGGCTCGGCTTCGAATATCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCGGTGATCGA
GAGCCTGCGCGATGCGACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGTCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGCACACGGCTGCCCGCGCACGCGACGACGCATGGCCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAACTGCGTGCGCTGTATCCGGAAGGCGCGCTGAGCCGGATGACGAGCGCGAC
GCCGGAGACGGTCGATGCGTTGTACGAAGTGATCCGCGAAGATGCGCTGCGTGGATACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGGATCTCGGTCGTCACGGCGCCGGTGCGCAACGAGACGCAGCGGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGTCCGGAGATCGACGCGGCGCTGATCGCCGACGGGCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAATTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTCTCAAGGCTTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A807EG32

Antitoxin

Source ID Structure
AlphaFold DB A0A807EEJ6

References