Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 1389201..1389834 Replicon chromosome
Accession NZ_CP013372
Organism Burkholderia sp. NRF60-BP8

Toxin (Protein)


Gene name vapC Uniprot ID A0A807EDE7
Locus tag WS54_RS06390 Protein ID WP_034204833.1
Coordinates 1389421..1389834 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A807EDB2
Locus tag WS54_RS06385 Protein ID WP_027808267.1
Coordinates 1389201..1389434 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WS54_RS06375 1385857..1388157 + 2301 WP_059783523.1 ATP-dependent DNA helicase -
WS54_RS06380 1388265..1389038 - 774 WP_034204834.1 helix-turn-helix domain-containing protein -
WS54_RS06385 1389201..1389434 + 234 WP_027808267.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
WS54_RS06390 1389421..1389834 + 414 WP_034204833.1 PIN domain-containing protein Toxin
WS54_RS06395 1389906..1391207 - 1302 WP_059783521.1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase -
WS54_RS06400 1391459..1392187 + 729 WP_034204831.1 HNH endonuclease -
WS54_RS06405 1392220..1393527 - 1308 WP_034204830.1 shikimate transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(10-119)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15677.94 Da        Isoelectric Point: 5.2432

>T58526 WP_034204833.1 NZ_CP013372:1389421-1389834 [Burkholderia sp. NRF60-BP8]
MSRIETEKSFVDSNVVLYLLSDDETKANRAEALFLRRPTLSVQVLNEVASVCNRKLRMPWREVGEFLEPIRRLCHVVPLT
VDAHDLARRLAEWHRLSFYDACIVATASIEGCEYLYTEDMHDGLQVDGGPVLRNPFA

Download         Length: 414 bp

>T58526 NZ_CP013372:1389421-1389834 [Burkholderia sp. NRF60-BP8]
ATGAGCAGGATTGAGACGGAGAAATCGTTCGTCGACAGCAATGTCGTGCTTTATCTGCTGTCCGACGACGAAACCAAGGC
AAATCGTGCGGAAGCGCTGTTCCTGCGGCGGCCAACCCTCAGCGTCCAGGTATTGAACGAGGTCGCCAGTGTCTGCAACC
GCAAACTGCGGATGCCGTGGCGCGAGGTCGGGGAGTTTCTGGAGCCGATCAGGCGTTTGTGCCATGTCGTGCCGCTCACC
GTCGATGCGCACGACCTCGCGCGGCGGCTGGCGGAGTGGCATCGGCTGTCCTTCTACGACGCATGCATCGTGGCCACTGC
TTCGATCGAGGGGTGCGAATATCTGTACACCGAAGACATGCACGACGGCTTGCAAGTGGACGGCGGTCCGGTATTGCGCA
ATCCGTTTGCTTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8807.99 Da        Isoelectric Point: 5.1468

>AT58526 WP_027808267.1 NZ_CP013372:1389201-1389434 [Burkholderia sp. NRF60-BP8]
MQVAKWGNSLAVRLPASVVDALELREGDDIEIVVDSPRVFAVSRKPRPDELLERLRRFRGKLPADFKFSRDDANEQD

Download         Length: 234 bp

>AT58526 NZ_CP013372:1389201-1389434 [Burkholderia sp. NRF60-BP8]
ATGCAAGTCGCAAAATGGGGCAATAGCCTGGCAGTTCGCCTTCCGGCCAGTGTGGTTGACGCACTGGAACTCCGCGAAGG
CGACGATATCGAGATTGTGGTCGACAGTCCCCGGGTTTTCGCGGTGAGCCGCAAGCCGAGGCCCGACGAGCTTCTGGAGC
GGCTGCGGCGCTTCAGGGGCAAGTTGCCCGCCGATTTCAAGTTCAGCCGGGACGATGCGAATGAGCAGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A807EDE7

Antitoxin

Source ID Structure
AlphaFold DB A0A807EDB2

References