Detailed information of TA system TA058519

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2125710..2126365
• Replicon: chromosome
• Accession: NZ_CP013371
• Organism: Burkholderia ubonensis strain RF23-BP41

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: WI31_RS30685
• Protein ID: WP_059656356.1
• Coordinates: 2125710..2126129 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A118DBD4
• Locus tag: WI31_RS30690
• Protein ID: WP_059612707.1
• Coordinates: 2126126..2126365 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WI31_RS30655	2120899..2121699	+	801	WP_059656352.1	AraC family transcriptional regulator	-
WI31_RS30660	2121791..2122723	+	933	WP_059612776.1	DMT family transporter	-
WI31_RS30665	2122913..2123485	+	573	WP_059656783.1	hypothetical protein	-
WI31_RS30670	2123588..2123722	-	135	WP_029226154.1	entericidin A/B family lipoprotein	-
WI31_RS30675	2123953..2125248	+	1296	WP_059612703.1	aspartate carbamoyltransferase	-
WI31_RS30680	2125383..2125700	+	318	WP_059656354.1	hypothetical protein	-
WI31_RS30685	2125710..2126129	-	420	WP_059656356.1	type II toxin-antitoxin system VapC family toxin	Toxin
WI31_RS30690	2126126..2126365	-	240	WP_059612707.1	Arc family DNA-binding protein	Antitoxin
WI31_RS30695	2126675..2128912	+	2238	WP_059656357.1	TonB-dependent siderophore receptor	-
WI31_RS30700	2128916..2129671	+	756	WP_059656359.1	sel1 repeat family protein	-
WI31_RS30705	2129668..2130351	+	684	WP_059616496.1	Fe2+-dependent dioxygenase	-
WI31_RS30710	2130477..2130716	+	240	WP_011659184.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
WI31_RS30715	2130713..2131108	+	396	WP_059612782.1	type II toxin-antitoxin system VapC family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

• Arc-like DNA binding domain (7-46)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14988.26 Da
• Isoelectric Point: 5.8883

>T58519 WP_059656356.1 NZ_CP013371:c2126129-2125710 [Burkholderia ubonensis]
MILVDTNVLSEPLRPAPNASVVEWLDAQNVETLFLAAISLAELRFGVAAMPEGKRRDWLHRSIEQRVVPAFRGRILPFDA
AASEAYARLRARARAAGSVIAPADGYIAATAEVNGLIVATRDVAPFEAAGLRVIDPWAV

Nucleotide

• Length: 420 bp

>T58519 NZ_CP013371:c2126129-2125710 [Burkholderia ubonensis]
ATGATTCTCGTCGATACCAACGTCTTGTCCGAGCCGCTGCGGCCTGCGCCGAATGCGTCAGTGGTGGAGTGGCTCGATGC
GCAGAATGTCGAAACGTTGTTTCTCGCGGCGATCAGTCTGGCCGAGCTGAGATTCGGCGTCGCGGCCATGCCGGAAGGCA
AGCGGCGAGACTGGCTGCATCGAAGCATCGAACAACGCGTGGTGCCGGCGTTTCGCGGCCGGATCCTGCCGTTCGACGCC
GCTGCGAGCGAGGCCTATGCCCGGCTTCGCGCACGTGCGCGGGCGGCCGGCAGCGTGATCGCGCCGGCCGACGGCTATAT
CGCCGCGACTGCCGAAGTAAATGGATTGATCGTGGCGACGCGCGACGTCGCGCCGTTTGAAGCGGCCGGCCTGCGGGTGA
TCGATCCGTGGGCGGTGTAG

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8810.07 Da
• Isoelectric Point: 5.7135

>AT58519 WP_059612707.1 NZ_CP013371:c2126365-2126126 [Burkholderia ubonensis]
MPVITVRNLPDEVHRALRVRAAQHGRSTEAEVRDILEKAVQPEGRVKLGALLAEIGREIGGVDLDIQRDKTPTEPMNFE

Nucleotide

• Length: 240 bp

>AT58519 NZ_CP013371:c2126365-2126126 [Burkholderia ubonensis]
ATGCCCGTGATAACCGTTCGAAATTTGCCTGACGAAGTTCATCGCGCCCTTCGGGTTCGCGCGGCGCAGCATGGACGCAG
CACCGAAGCGGAGGTGCGTGACATCCTCGAGAAAGCGGTTCAGCCGGAAGGGCGCGTCAAATTGGGAGCGTTGCTGGCGG
AAATCGGGCGGGAAATCGGGGGTGTCGATCTCGACATTCAGCGCGACAAAACTCCAACCGAGCCGATGAACTTCGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A118DBD4