Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1512267..1512906 Replicon chromosome
Accession NZ_CP013371
Organism Burkholderia ubonensis strain RF23-BP41

Toxin (Protein)


Gene name vapC Uniprot ID A0A102XHA3
Locus tag WI31_RS28250 Protein ID WP_059613565.1
Coordinates 1512490..1512906 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A102KI40
Locus tag WI31_RS36015 Protein ID WP_059637996.1
Coordinates 1512267..1512503 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WI31_RS28230 1507763..1509064 - 1302 WP_059613556.1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase -
WI31_RS28235 1509253..1510560 - 1308 WP_059649962.1 shikimate transporter -
WI31_RS28240 1510921..1512048 + 1128 WP_059613560.1 VOC family protein -
WI31_RS36015 1512267..1512503 + 237 WP_059637996.1 hypothetical protein Antitoxin
WI31_RS28250 1512490..1512906 + 417 WP_059613565.1 type II toxin-antitoxin system VapC family toxin Toxin
WI31_RS28255 1513164..1513367 + 204 WP_010089472.1 cold-shock protein -
WI31_RS28260 1513900..1514166 + 267 WP_010089473.1 translation initiation factor IF-1 -
WI31_RS28265 1514419..1515666 + 1248 WP_059649964.1 phosphoesterase -
WI31_RS28270 1515663..1515902 + 240 WP_059637992.1 hypothetical protein -
WI31_RS36020 1516046..1516291 - 246 WP_059709237.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15456.74 Da        Isoelectric Point: 6.2356

>T58517 WP_059613565.1 NZ_CP013371:1512490-1512906 [Burkholderia ubonensis]
MFLIDTNVISEIRKGKRTNDGVRAFFRQAEADASALYLSVVTVSELRRGVEMIRHRGDVRQASTLEAWLETLLSDYAPNI
LPVDIEISQVWGMLRAPHPAHELDKLIAATALINDLTVVTRNVGDFARTGVRLLNPFE

Download         Length: 417 bp

>T58517 NZ_CP013371:1512490-1512906 [Burkholderia ubonensis]
ATGTTTTTGATTGATACGAACGTCATCAGCGAAATCAGAAAGGGAAAGCGAACCAACGATGGGGTGCGCGCGTTCTTTCG
GCAAGCCGAAGCCGACGCGAGCGCGCTTTACCTGTCCGTCGTGACGGTGTCCGAGCTGCGGCGCGGCGTCGAGATGATCC
GTCATCGCGGCGACGTCCGGCAGGCGTCGACCCTCGAAGCATGGCTGGAGACGCTCCTGTCCGACTATGCGCCGAACATC
CTGCCGGTCGATATCGAGATCAGCCAGGTATGGGGGATGCTGCGCGCGCCCCATCCGGCGCACGAACTGGACAAGCTGAT
CGCAGCCACCGCGCTGATCAACGACCTGACGGTCGTGACCCGCAACGTCGGCGATTTCGCGAGAACCGGCGTGAGGCTGC
TGAATCCGTTCGAGTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8555.51 Da        Isoelectric Point: 5.6088

>AT58517 WP_059637996.1 NZ_CP013371:1512267-1512503 [Burkholderia ubonensis]
MANLLVRNVDDSIVQSLREQAAAHGRSAEAEHRAILASALARPKRKTFAEALKGIPDVGEDTDFERVQDSGEARHVFD

Download         Length: 237 bp

>AT58517 NZ_CP013371:1512267-1512503 [Burkholderia ubonensis]
ATGGCCAATCTACTGGTGCGTAACGTGGATGACAGTATCGTTCAGAGCCTGCGCGAGCAGGCCGCGGCGCACGGCCGGAG
TGCGGAGGCCGAGCATCGCGCCATTCTCGCGAGCGCGCTCGCCCGGCCGAAGCGCAAGACCTTCGCGGAAGCGCTGAAGG
GCATCCCCGATGTTGGCGAAGACACGGATTTCGAGCGCGTGCAGGATTCCGGCGAGGCCAGGCATGTTTTTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A102XHA3

Antitoxin

Source ID Structure
AlphaFold DB A0A102KI40

References