Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1813084..1813760 Replicon chromosome
Accession NZ_CP013370
Organism Burkholderia ubonensis strain RF23-BP41

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag WI31_RS12875 Protein ID WP_059654112.1
Coordinates 1813344..1813760 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag WI31_RS12870 Protein ID WP_059654114.1
Coordinates 1813084..1813347 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WI31_RS12855 1808723..1810927 + 2205 WP_059654264.1 TonB-dependent siderophore receptor -
WI31_RS12860 1811013..1811861 + 849 WP_059617418.1 N(5)-hydroxyornithine transformylase PvdF -
WI31_RS12865 1811861..1812871 + 1011 WP_059654117.1 acetyltransferase -
WI31_RS12870 1813084..1813347 + 264 WP_059654114.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
WI31_RS12875 1813344..1813760 + 417 WP_059654112.1 PIN domain-containing protein Toxin
WI31_RS12880 1813920..1815083 + 1164 WP_059654109.1 amidohydrolase -
WI31_RS12885 1815105..1816409 - 1305 WP_059654106.1 cobyrinate a,c-diamide synthase -
WI31_RS12890 1816413..1817015 - 603 WP_010092402.1 cob(I)yrinic acid a,c-diamide adenosyltransferase -
WI31_RS12895 1817044..1817421 - 378 WP_059481718.1 cobalamin biosynthesis protein -
WI31_RS12900 1817418..1818200 - 783 WP_059635561.1 uroporphyrinogen-III C-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14635.75 Da        Isoelectric Point: 7.3223

>T58513 WP_059654112.1 NZ_CP013370:1813344-1813760 [Burkholderia ubonensis]
VTKLYMLDTNICSYIMRERPPVVLSRLQSCVGGQHRIVVSAVTYAEMRFGAIGKKASPKHADLVTAFVSRLDGVLPWDAA
AVDATAAVRAELAARGTPIGANDASIAGHAIAAGAVLVTHNTREFGRVDGLSFEDWAD

Download         Length: 417 bp

>T58513 NZ_CP013370:1813344-1813760 [Burkholderia ubonensis]
GTGACGAAGCTCTACATGCTCGATACGAACATCTGCTCGTACATCATGCGGGAGCGCCCGCCGGTCGTGCTGTCGCGGCT
GCAGTCGTGCGTCGGCGGGCAGCACCGGATCGTCGTGTCGGCCGTCACCTATGCGGAGATGCGCTTCGGCGCGATCGGCA
AGAAGGCGTCGCCGAAGCATGCCGACCTCGTGACCGCATTCGTCTCGCGGCTGGACGGCGTGCTGCCGTGGGATGCGGCG
GCCGTCGACGCGACGGCCGCCGTGCGCGCCGAGCTCGCGGCGCGCGGCACGCCGATCGGCGCGAACGATGCGTCGATCGC
GGGGCACGCGATCGCGGCCGGCGCGGTGCTGGTGACCCACAACACGCGCGAATTCGGCCGCGTCGACGGGCTGTCGTTCG
AGGACTGGGCGGATTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9749.96 Da        Isoelectric Point: 4.5098

>AT58513 WP_059654114.1 NZ_CP013370:1813084-1813347 [Burkholderia ubonensis]
MRTVSIFKNASNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWTSLAHEPLADADFLVERPAVVESGRFDLSGPDD
AQPESGR

Download         Length: 264 bp

>AT58513 NZ_CP013370:1813084-1813347 [Burkholderia ubonensis]
ATGCGCACCGTATCCATTTTCAAGAATGCCAGCAATCAGGCGATCCGCATCCCGAAGGACATGGAGTTCGAAGGGGTGAC
GGAACTCGAGATCCGCCGCGAGGGCGACACCCTGCTGCTCCGCCCGGTGCGTCCCACGTGGACGTCGCTCGCGCACGAGC
CGCTTGCGGATGCCGATTTTCTCGTCGAGCGCCCGGCCGTCGTCGAATCCGGCCGTTTCGACCTGTCCGGCCCCGACGAT
GCGCAACCGGAGTCCGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References