Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 562673..563250 Replicon chromosome
Accession NZ_CP013368
Organism Burkholderia ubonensis strain RF23-BP41

Toxin (Protein)


Gene name vapC Uniprot ID A0A117XCH8
Locus tag WI31_RS02005 Protein ID WP_059632130.1
Coordinates 562673..563038 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A118DAA4
Locus tag WI31_RS02010 Protein ID WP_059615365.1
Coordinates 563032..563250 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WI31_RS01990 558535..558882 - 348 WP_010098558.1 GIY-YIG nuclease family protein -
WI31_RS01995 558940..559641 - 702 WP_059615370.1 autoinducer binding domain-containing protein -
WI31_RS36310 560205..560486 - 282 WP_155122780.1 hypothetical protein -
WI31_RS02000 560508..562676 - 2169 WP_059657335.1 DUF4132 domain-containing protein -
WI31_RS02005 562673..563038 - 366 WP_059632130.1 type II toxin-antitoxin system VapC family toxin Toxin
WI31_RS02010 563032..563250 - 219 WP_059615365.1 ribbon-helix-helix protein, CopG family Antitoxin
WI31_RS02015 563342..564664 - 1323 WP_059657332.1 HipA domain-containing protein -
WI31_RS02020 564661..565212 - 552 WP_059657415.1 helix-turn-helix domain-containing protein -
WI31_RS36315 565211..565600 + 390 WP_155122781.1 hypothetical protein -
WI31_RS02025 566067..567659 + 1593 WP_059615361.1 DUF2957 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-106)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-41)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13305.39 Da        Isoelectric Point: 4.8018

>T58511 WP_059632130.1 NZ_CP013368:c563038-562673 [Burkholderia ubonensis]
MVNALFDTNILIDYLNGVDAAKTELARYPAPAISTITWMEVLVGTTPADDAPIRAWLATFEVVDLDSTIADRAVAIRKAR
RIRLPDAIVWASAQVRGLLLVSRNTKDFPAEEPGVRVPYVI

Download         Length: 366 bp

>T58511 NZ_CP013368:c563038-562673 [Burkholderia ubonensis]
ATGGTGAACGCCCTGTTCGACACCAATATCCTGATCGACTATCTGAACGGAGTCGACGCAGCAAAGACAGAACTCGCACG
ATATCCCGCGCCTGCGATCAGCACGATCACCTGGATGGAAGTGCTGGTCGGCACCACGCCTGCCGACGACGCGCCCATCC
GCGCGTGGCTGGCGACGTTCGAAGTGGTCGATCTCGACTCGACCATTGCCGACAGGGCCGTGGCGATCCGCAAAGCGAGG
CGAATTCGTCTACCCGATGCAATCGTCTGGGCGAGCGCGCAGGTCAGGGGGCTGCTGCTGGTCTCGCGCAACACGAAAGA
TTTCCCGGCCGAAGAGCCCGGCGTACGCGTTCCGTACGTCATATGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8035.27 Da        Isoelectric Point: 6.2897

>AT58511 WP_059615365.1 NZ_CP013368:c563250-563032 [Burkholderia ubonensis]
MSRILIDLPDAQVQALAAVVEAEQRPRAAVIRDAIDAYLAQRKRIAGADVFGLWKGKKVDGLAYQEALREEW

Download         Length: 219 bp

>AT58511 NZ_CP013368:c563250-563032 [Burkholderia ubonensis]
ATGAGCCGAATCCTGATTGACCTGCCGGACGCACAGGTCCAGGCCCTGGCGGCCGTGGTCGAGGCAGAGCAGCGGCCGCG
TGCGGCAGTCATCCGCGACGCGATCGACGCTTACCTCGCACAGCGCAAGCGCATAGCCGGCGCCGATGTGTTCGGCCTCT
GGAAGGGAAAGAAGGTCGACGGCCTGGCGTATCAAGAGGCGTTGCGCGAAGAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A117XCH8

Antitoxin

Source ID Structure
AlphaFold DB A0A118DAA4

References