Detailed information of TA system TA058510

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 1779421..1780106
• Replicon: chromosome
• Accession: NZ_CP013366
• Organism: Burkholderia territorii strain RF8-non-BP5

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: WS51_RS18780
• Protein ID: WP_059502005.1
• Coordinates: 1779684..1780106 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A125K6N0
• Locus tag: WS51_RS18775
• Protein ID: WP_059502004.1
• Coordinates: 1779421..1779687 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WS51_RS18760	1774951..1777200	+	2250	WP_069229629.1	TonB-dependent siderophore receptor	-
WS51_RS18765	1777290..1778129	+	840	WP_060330126.1	N(5)-hydroxyornithine transformylase PvdF	-
WS51_RS18770	1778129..1779151	+	1023	WP_069229630.1	acetyltransferase	-
WS51_RS18775	1779421..1779687	+	267	WP_059502004.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
WS51_RS18780	1779684..1780106	+	423	WP_059502005.1	PIN domain-containing protein	Toxin
WS51_RS18785	1780150..1781055	-	906	WP_069229631.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
WS51_RS18790	1781024..1782091	-	1068	WP_059771045.1	hypothetical protein	-
WS51_RS18795	1782450..1783613	+	1164	WP_059502012.1	amidohydrolase	-
WS51_RS18800	1783781..1784320	+	540	WP_059502183.1	outer membrane protein assembly factor BamE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-130)

Antitoxin

• SpoVT-AbrB domain (7-53)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 14682.76 Da
• Isoelectric Point: 7.8895

>T58510 WP_059502005.1 NZ_CP013366:1779684-1780106 [Burkholderia territorii]
VTTLYMLDTNICSFIMRERPPAVLSRLQSCVNAQHRIVVSSITYAEMRFGAVGRKASPKHADLVAAFVARLDGVLSWDTA
AVDATAAIRADLAARGTPIGANDASIAGHAIAAGAVLVTNNGREFSRVAGLSLEDWTASA

Nucleotide

• Length: 423 bp

>T58510 NZ_CP013366:1779684-1780106 [Burkholderia territorii]
GTGACCACGCTCTACATGCTCGATACGAACATCTGCTCGTTCATCATGCGCGAGCGGCCGCCCGCGGTGTTGTCCCGGCT
GCAGTCGTGCGTCAACGCGCAGCACCGGATCGTCGTGTCGTCGATCACCTATGCCGAAATGCGGTTCGGCGCGGTCGGCA
GAAAGGCGTCGCCGAAGCATGCGGATCTCGTGGCGGCGTTCGTCGCACGACTGGACGGCGTGTTGTCGTGGGATACCGCG
GCGGTCGATGCAACGGCCGCGATTCGCGCCGACCTTGCCGCACGCGGGACGCCGATCGGCGCGAACGATGCATCGATCGC
CGGCCATGCGATCGCGGCCGGTGCCGTGCTCGTCACGAACAATGGACGCGAATTCAGCCGCGTCGCGGGGTTGTCGCTCG
AAGACTGGACGGCTTCGGCTTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9771.02 Da
• Isoelectric Point: 4.5112

>AT58510 WP_059502004.1 NZ_CP013366:1779421-1779687 [Burkholderia territorii]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWLSLASEPLADADFLAERPAVVEAGRFDLSGTDG
DAPTESGR

Nucleotide

• Length: 267 bp

>AT58510 NZ_CP013366:1779421-1779687 [Burkholderia territorii]
ATGCGCACCGTTTCCATTTTCAAGAACGCCCGTAACCAGGCAATCCGCATCCCGAAGGACATGGAGTTCGAGGGTGTGAC
GGAACTCGAAATCCGCCGCGAGGGCGACACGCTGCTGCTGCGTCCGGTGCGGCCGACATGGCTGTCGCTGGCGAGCGAAC
CGCTGGCCGATGCCGACTTCCTCGCCGAGCGCCCTGCTGTCGTCGAAGCGGGGCGTTTCGACCTGTCCGGCACGGATGGC
GACGCACCGACGGAGTCGGGCCGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A125K6N0