Detailed information of TA system TA058509

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbE-relB/ParE-YafN
• Location: 2319347..2319880
• Replicon: chromosome
• Accession: NZ_CP013365
• Organism: Burkholderia territorii strain RF8-non-BP5

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: -
• Locus tag: WS51_RS10185
• Protein ID: WP_069229053.1
• Coordinates: 2319347..2319610 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A108LKY6
• Locus tag: WS51_RS10190
• Protein ID: WP_048023838.1
• Coordinates: 2319632..2319880 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WS51_RS10165	2315067..2315765	-	699	WP_069229050.1	MgtC/SapB family protein	-
WS51_RS10170	2315872..2316981	+	1110	WP_069229051.1	AGE family epimerase/isomerase	-
WS51_RS10175	2316954..2318582	-	1629	WP_069229052.1	Tar ligand binding domain-containing protein	-
WS51_RS10180	2318854..2319297	+	444	WP_044845017.1	PaaI family thioesterase	-
WS51_RS10185	2319347..2319610	-	264	WP_069229053.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
WS51_RS10190	2319632..2319880	-	249	WP_048023838.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
WS51_RS10195	2319998..2321050	-	1053	WP_069229054.1	CoA transferase	-
WS51_RS10200	2321324..2322514	-	1191	WP_069229055.1	2-methylaconitate cis-trans isomerase PrpF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-73)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10391.11 Da
• Isoelectric Point: 11.2945

>T58509 WP_069229053.1 NZ_CP013365:c2319610-2319347 [Burkholderia territorii]
MKEWKKLDRTVRDQFKARLAERLENPRIPSAKLHGHPDRYKIKLRSVGYRLVYEVRESEVVVLVVAVGRRERDAVYLAAM
RRSRDTR

Nucleotide

• Length: 264 bp

>T58509 NZ_CP013365:c2319610-2319347 [Burkholderia territorii]
TTGAAGGAATGGAAGAAGCTCGATCGCACCGTTCGCGATCAGTTCAAGGCGAGACTCGCCGAACGTCTCGAAAATCCGCG
CATTCCTTCTGCGAAACTGCATGGTCATCCGGACCGATACAAGATCAAGCTGCGCAGTGTCGGCTATCGCCTCGTGTACG
AAGTGCGCGAGTCGGAGGTTGTCGTGCTGGTGGTCGCAGTGGGGCGTCGCGAGCGCGATGCCGTCTATCTCGCCGCGATG
AGACGCTCGCGCGACACGCGCTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8963.31 Da
• Isoelectric Point: 5.0636

>AT58509 WP_048023838.1 NZ_CP013365:c2319880-2319632 [Burkholderia territorii]
MPHTILASVTASVSELKRNPMGTVAAGEGFPVAILNHNEPAFYCIPAKTWEAMVERLEDIEDNALADSRAKEKVVKVKLN
DL

Nucleotide

• Length: 249 bp

>AT58509 NZ_CP013365:c2319880-2319632 [Burkholderia territorii]
ATGCCCCACACCATTCTGGCCAGCGTGACGGCGAGCGTTTCGGAGCTGAAGCGGAACCCGATGGGAACCGTTGCGGCGGG
CGAGGGCTTTCCGGTCGCGATCCTGAACCACAACGAACCCGCGTTCTATTGCATCCCGGCGAAGACATGGGAGGCGATGG
TCGAACGTCTCGAAGATATTGAAGACAACGCGCTTGCCGATTCACGCGCGAAGGAGAAAGTCGTCAAGGTCAAACTGAAT
GACCTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A108LKY6