Detailed information of TA system TA058505

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-PumB/upstrm_HI1419-dnstrm_HI1420
• Location: 508533..509173
• Replicon: chromosome
• Accession: NZ_CP013365
• Organism: Burkholderia territorii strain RF8-non-BP5

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A104DPZ6
• Locus tag: WS51_RS02400
• Protein ID: WP_059466579.1
• Coordinates: 508835..509173 (-)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: WS51_RS02395
• Protein ID: WP_006750245.1
• Coordinates: 508533..508832 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WS51_RS02365	503661..504566	-	906	WP_059448774.1	LysR family transcriptional regulator	-
WS51_RS02370	504663..505613	+	951	WP_069228543.1	ketopantoate reductase family protein	-
WS51_RS02375	505610..506002	+	393	WP_059503681.1	VOC family protein	-
WS51_RS02380	506005..506463	+	459	WP_059504048.1	MaoC family dehydratase	-
WS51_RS02385	506463..507674	+	1212	WP_060361628.1	CoA transferase	-
WS51_RS02390	507682..508515	+	834	WP_059503677.1	shikimate dehydrogenase	-
WS51_RS02395	508533..508832	-	300	WP_006750245.1	putative addiction module antidote protein	Antitoxin
WS51_RS02400	508835..509173	-	339	WP_059466579.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
WS51_RS02405	509538..511178	+	1641	WP_059503675.1	acetolactate synthase large subunit	-
WS51_RS02410	511207..512640	+	1434	WP_069228544.1	aldehyde dehydrogenase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (26-103)

Antitoxin

• Uncharacterized protein HI1420 (5-93)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12715.57 Da
• Isoelectric Point: 8.9562

>T58505 WP_059466579.1 NZ_CP013365:c509173-508835 [Burkholderia territorii]
MVDTLPFMPYSAPTFSIRTTDVFDAWFAGLQDRVARRRIQARIDRLSMGNPGDWKSAGSPVVEMRVDHGPGYRVYYVRRG
TIWVILLCGGDKSTQQADIRAAHAMLERLDLE

Nucleotide

• Length: 339 bp

>T58505 NZ_CP013365:c509173-508835 [Burkholderia territorii]
ATGGTTGACACATTGCCATTCATGCCCTACAGTGCGCCTACATTCAGTATCCGGACCACCGACGTCTTCGATGCATGGTT
TGCCGGCCTGCAGGATCGCGTCGCGCGGCGGCGCATCCAGGCACGCATCGATCGTCTGTCGATGGGCAACCCGGGCGACT
GGAAATCCGCCGGCTCGCCCGTCGTCGAAATGCGTGTCGACCACGGCCCCGGCTATCGCGTCTATTACGTCAGACGCGGA
ACGATTTGGGTGATCCTGCTCTGCGGCGGCGACAAGTCGACGCAACAGGCGGACATCCGCGCCGCGCACGCGATGCTCGA
GCGGCTCGACCTGGAGTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10674.11 Da
• Isoelectric Point: 6.6384

>AT58505 WP_006750245.1 NZ_CP013365:c508832-508533 [Burkholderia territorii]
MDKIKTRPWDSAEHLKTDDDMADYFEACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Nucleotide

• Length: 300 bp

>AT58505 NZ_CP013365:c508832-508533 [Burkholderia territorii]
ATGGACAAGATCAAGACCCGGCCGTGGGATTCGGCCGAACACCTGAAGACCGACGACGACATGGCCGACTACTTCGAGGC
CTGTCTGCAGGAAGCCGGCGACGATCCGGCCTTCATCGCGCATGCGCTCGGCGTGATCGCCCGTGCGCGCGGCATGTCGC
AGGTCGCGCGCGACGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGTTTCGGCACG
ATCCTGAAGGTGATCAAGGCACTCGGCCTCCAACTGCACGGCGCGAAGGCGCATGCGTGA

Structures

Toxin

• AlphaFold DB: A0A104DPZ6