Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 1909636..1910882 | Replicon | chromosome |
| Accession | NZ_CP013363 | ||
| Organism | Burkholderia diffusa strain RF2-non-BP9 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | A0A1B4C0Z1 |
| Locus tag | WI26_RS23820 | Protein ID | WP_069227389.1 |
| Coordinates | 1910301..1910882 (+) | Length | 194 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | A0A1B4C331 |
| Locus tag | WI26_RS23815 | Protein ID | WP_069227852.1 |
| Coordinates | 1909636..1910193 (+) | Length | 186 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| WI26_RS23795 | 1905454..1906089 | + | 636 | WP_069227387.1 | cysteine hydrolase | - |
| WI26_RS23800 | 1906156..1906887 | - | 732 | WP_059915184.1 | ribonuclease T2 | - |
| WI26_RS23805 | 1907137..1908540 | - | 1404 | WP_069227851.1 | hypothetical protein | - |
| WI26_RS23810 | 1908896..1909570 | + | 675 | WP_069227388.1 | hypothetical protein | - |
| WI26_RS23815 | 1909636..1910193 | + | 558 | WP_069227852.1 | helix-turn-helix domain-containing protein | Antitoxin |
| WI26_RS23820 | 1910301..1910882 | + | 582 | WP_069227389.1 | HD domain-containing protein | Toxin |
| WI26_RS23825 | 1910942..1911670 | + | 729 | WP_069227390.1 | class I SAM-dependent methyltransferase | - |
| WI26_RS23830 | 1911682..1913220 | - | 1539 | WP_069227391.1 | MFS transporter | - |
| WI26_RS23835 | 1913398..1914303 | + | 906 | WP_059466767.1 | LysR family transcriptional regulator | - |
| WI26_RS23840 | 1914375..1915514 | - | 1140 | WP_069227392.1 | enoyl-CoA hydratase/isomerase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 194 a.a. Molecular weight: 21309.88 Da Isoelectric Point: 4.9474
>T58503 WP_069227389.1 NZ_CP013363:1910301-1910882 [Burkholderia diffusa]
MNLDTIHARLDFLRDAERLKDVLRSGHTSTGRAESTAEHSWRLCLMALVFADALPDVDTTKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSTHERADLLTLTAGLDRALRDEIVALWDEYEAAVSPEARAAKALDKLETILQHNQGSNPPDFDYAFNLGY
GRRYTDAAPLFGAIRAIVDADTQRRIDARGNDA
MNLDTIHARLDFLRDAERLKDVLRSGHTSTGRAESTAEHSWRLCLMALVFADALPDVDTTKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSTHERADLLTLTAGLDRALRDEIVALWDEYEAAVSPEARAAKALDKLETILQHNQGSNPPDFDYAFNLGY
GRRYTDAAPLFGAIRAIVDADTQRRIDARGNDA
Download Length: 582 bp
>T58503 NZ_CP013363:1910301-1910882 [Burkholderia diffusa]
ATGAACCTCGACACGATCCACGCGCGGCTGGATTTCCTGCGCGACGCCGAACGCCTGAAAGACGTGCTGCGCAGCGGCCA
TACGTCGACCGGGCGCGCCGAAAGCACTGCCGAACACAGCTGGCGGCTGTGCCTGATGGCGCTCGTGTTTGCCGATGCAC
TACCCGACGTCGACACGACGAAGCTGCTGAAGCTGTGCGTCGTCCACGATCTCGGCGAAGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCACACCCGGACAAGAGCACACACGAACGCGCCGACCTGCTGACGCTGACAGCCGGGCTCGATCG
CGCGCTGCGCGACGAGATCGTCGCGCTGTGGGACGAATACGAGGCGGCGGTGTCACCGGAAGCGCGCGCCGCGAAGGCAC
TCGACAAACTCGAGACGATCCTGCAGCACAACCAGGGCAGCAATCCGCCGGATTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGGCGCTACACCGACGCGGCGCCGCTGTTCGGCGCGATCCGCGCGATCGTCGACGCGGACACCCAACGCCGGATCGA
CGCACGCGGCAACGACGCGTAA
ATGAACCTCGACACGATCCACGCGCGGCTGGATTTCCTGCGCGACGCCGAACGCCTGAAAGACGTGCTGCGCAGCGGCCA
TACGTCGACCGGGCGCGCCGAAAGCACTGCCGAACACAGCTGGCGGCTGTGCCTGATGGCGCTCGTGTTTGCCGATGCAC
TACCCGACGTCGACACGACGAAGCTGCTGAAGCTGTGCGTCGTCCACGATCTCGGCGAAGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCACACCCGGACAAGAGCACACACGAACGCGCCGACCTGCTGACGCTGACAGCCGGGCTCGATCG
CGCGCTGCGCGACGAGATCGTCGCGCTGTGGGACGAATACGAGGCGGCGGTGTCACCGGAAGCGCGCGCCGCGAAGGCAC
TCGACAAACTCGAGACGATCCTGCAGCACAACCAGGGCAGCAATCCGCCGGATTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGGCGCTACACCGACGCGGCGCCGCTGTTCGGCGCGATCCGCGCGATCGTCGACGCGGACACCCAACGCCGGATCGA
CGCACGCGGCAACGACGCGTAA
Antitoxin
Download Length: 186 a.a. Molecular weight: 20275.36 Da Isoelectric Point: 11.0874
>AT58503 WP_069227852.1 NZ_CP013363:1909636-1910193 [Burkholderia diffusa]
MRASPLHTPPLGPQLKRWRTLHRVKQSHAAELFGVAQSTISRWEAGIQQMSVDERAMAEQLLAARLDSAGDRALARLIAG
STARMHLVCDLTHRLLACSPSRAAEFSRPLSTLLGTSLWRYASPEIVRMEAALDPLGWHDRAGPPSVEFATGANASRVVP
IRGSTCRWTRMMLSDGSAARLVETL
MRASPLHTPPLGPQLKRWRTLHRVKQSHAAELFGVAQSTISRWEAGIQQMSVDERAMAEQLLAARLDSAGDRALARLIAG
STARMHLVCDLTHRLLACSPSRAAEFSRPLSTLLGTSLWRYASPEIVRMEAALDPLGWHDRAGPPSVEFATGANASRVVP
IRGSTCRWTRMMLSDGSAARLVETL
Download Length: 558 bp
>AT58503 NZ_CP013363:1909636-1910193 [Burkholderia diffusa]
ATGCGCGCCTCACCGCTTCACACCCCGCCGCTCGGCCCGCAACTCAAGCGTTGGCGCACGCTGCATCGCGTGAAGCAGAG
CCACGCGGCCGAGTTGTTCGGCGTTGCGCAATCGACGATCTCGCGTTGGGAAGCCGGCATCCAGCAGATGTCTGTCGACG
AGCGCGCGATGGCCGAACAGCTGCTTGCCGCGCGTCTCGATTCTGCGGGCGATCGTGCGCTCGCCCGGCTGATCGCGGGC
AGCACGGCCCGCATGCATCTCGTGTGCGACCTCACGCACCGTCTGCTCGCCTGCTCGCCGTCGCGCGCGGCCGAGTTCTC
GCGGCCGCTGTCGACATTGCTCGGCACGTCGCTCTGGCGGTACGCGTCGCCGGAGATCGTCCGCATGGAAGCCGCGCTCG
ACCCACTCGGCTGGCACGATCGCGCGGGACCGCCGAGCGTCGAATTCGCGACCGGCGCCAATGCGTCGCGCGTCGTGCCG
ATCCGCGGCAGCACCTGCCGATGGACGCGGATGATGCTGTCGGACGGCTCGGCCGCGCGGCTCGTCGAAACTCTGTAG
ATGCGCGCCTCACCGCTTCACACCCCGCCGCTCGGCCCGCAACTCAAGCGTTGGCGCACGCTGCATCGCGTGAAGCAGAG
CCACGCGGCCGAGTTGTTCGGCGTTGCGCAATCGACGATCTCGCGTTGGGAAGCCGGCATCCAGCAGATGTCTGTCGACG
AGCGCGCGATGGCCGAACAGCTGCTTGCCGCGCGTCTCGATTCTGCGGGCGATCGTGCGCTCGCCCGGCTGATCGCGGGC
AGCACGGCCCGCATGCATCTCGTGTGCGACCTCACGCACCGTCTGCTCGCCTGCTCGCCGTCGCGCGCGGCCGAGTTCTC
GCGGCCGCTGTCGACATTGCTCGGCACGTCGCTCTGGCGGTACGCGTCGCCGGAGATCGTCCGCATGGAAGCCGCGCTCG
ACCCACTCGGCTGGCACGATCGCGCGGGACCGCCGAGCGTCGAATTCGCGACCGGCGCCAATGCGTCGCGCGTCGTGCCG
ATCCGCGGCAGCACCTGCCGATGGACGCGGATGATGCTGTCGGACGGCTCGGCCGCGCGGCTCGTCGAAACTCTGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1B4C0Z1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1B4C331 |