Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1569225..1570978 Replicon chromosome
Accession NZ_CP013363
Organism Burkholderia diffusa strain RF2-non-BP9

Toxin (Protein)


Gene name doc Uniprot ID A0A1B4C074
Locus tag WI26_RS22285 Protein ID WP_069227215.1
Coordinates 1570082..1570978 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1B4C064
Locus tag WI26_RS22280 Protein ID WP_059509032.1
Coordinates 1569225..1570085 (-) Length 287 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WI26_RS22260 1564285..1565775 - 1491 WP_069227213.1 aldehyde dehydrogenase -
WI26_RS22265 1565865..1566692 - 828 WP_059464610.1 aspartate dehydrogenase -
WI26_RS22270 1566685..1568355 - 1671 WP_069227214.1 thiamine pyrophosphate-binding protein -
WI26_RS22275 1568348..1569145 - 798 WP_059539786.1 SDR family oxidoreductase -
WI26_RS22280 1569225..1570085 - 861 WP_059509032.1 IclR family transcriptional regulator Antitoxin
WI26_RS22285 1570082..1570978 - 897 WP_069227215.1 alpha/beta fold hydrolase Toxin
WI26_RS22290 1570997..1571524 - 528 WP_009692519.1 cupin domain-containing protein -
WI26_RS22295 1571559..1572329 - 771 WP_069227216.1 SDR family oxidoreductase -
WI26_RS22300 1572322..1573392 - 1071 WP_069227217.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
WI26_RS22305 1573447..1573758 - 312 WP_039321045.1 hypothetical protein -
WI26_RS22310 1573760..1574077 - 318 WP_006758060.1 non-heme iron oxygenase ferredoxin subunit -
WI26_RS22315 1574529..1575608 + 1080 WP_059464602.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, N-terminal

(25-73)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30863.09 Da        Isoelectric Point: 8.0625

>T58502 WP_069227215.1 NZ_CP013363:c1570978-1570082 [Burkholderia diffusa]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGASTPVHGASPTAADYAASLNAWLEALGIERCVLVGHSLGAIVAGGLARVMPARIAGLLLISPAGGYGSAPAETR
DTRRDARLAMLEELGPAGLAEQRSGNMLSGFASEDARAWVRWNMARIVPAGYAQATHLLANADLASDLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVRLQVIPQAGHAGYVEAPAVYSALIDAFCRQCDRQRGLE

Download         Length: 897 bp

>T58502 NZ_CP013363:c1570978-1570082 [Burkholderia diffusa]
ATGAGTGTCATCGACAAACGTGAACGCGATCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTTCCCGAACAGCGCTG
CGCGGCCGGCGCGGCGGGCACGATCGGCTATCGCGAGGCCGGCGCGCAGCATGCGGGCCGCGCGCTGCCCGTCGTGCTGC
TGCACGGGATCGGCTCGGGCGCCGCATCGTGGGTGCGCCAGCTCGACACGCTCGGTGCGTCGCGACGCGTGCTGGCGTGG
GACGCGCCCGGCTATGGCGCGTCGACCCCCGTGCACGGCGCGTCGCCGACGGCCGCCGATTACGCGGCGTCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTACTGGTCGGGCATTCGCTCGGTGCGATCGTCGCGGGCGGGTTGGCCC
GCGTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGATCTCGCCCGCGGGCGGTTACGGCAGTGCGCCTGCGGAAACGCGC
GACACGCGCCGCGATGCACGCCTCGCCATGCTCGAGGAACTCGGCCCGGCCGGGCTTGCAGAGCAGCGCAGCGGCAACAT
GCTGTCGGGTTTCGCGAGCGAGGATGCGCGTGCGTGGGTGCGCTGGAACATGGCACGCATCGTGCCGGCCGGCTATGCGC
AGGCCACGCACCTGCTCGCGAATGCCGATCTCGCGTCCGATCTCGCCGGCTTTCGCGGTCGCACGGCGGTCGCGGTCGGC
GCGAACGACGCGATCACGCCGCCCGCGGCGTGCGAGCGGATCGCCGCGGCCGCGCACGTCCGGCTGCAGGTGATTCCGCA
GGCCGGTCATGCAGGTTACGTGGAAGCACCGGCGGTGTATTCCGCGCTGATCGACGCGTTCTGTCGTCAATGCGATCGTC
AGCGGGGGCTGGAATGA

Antitoxin


Download         Length: 287 a.a.        Molecular weight: 31555.04 Da        Isoelectric Point: 6.3595

>AT58502 WP_059509032.1 NZ_CP013363:c1570085-1569225 [Burkholderia diffusa]
MSEPLQQQQDAEAAKSDANYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNY
KLGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHG
HVLMGDLSLKELRELYPESTLNRMTSATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNDTQKIVACITVTV
PRPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFMKALGLK

Download         Length: 861 bp

>AT58502 NZ_CP013363:c1570085-1569225 [Burkholderia diffusa]
ATGAGCGAACCGTTGCAACAGCAGCAGGACGCGGAAGCCGCGAAGTCCGACGCCAACTACGTGGTGCCGGGCCTCGAACG
CGGTTTGCGGATCCTCGCCGAATTCTCGCCGCGCGAGCCGGTACTGGGCGCGCCGGAGTTGTCCAAGCGGCTCGGCATTC
CGCGCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGCGCGGACAAGGATCGCAACTAC
AAGCTCGGCATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTCGAGCTGACCGATCTCGGCCTGCCGGTGAT
CGAGAGCCTGCGCGACGCGACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGGGACGTTGTGTTCGTCGCGAAGG
CGCAGAGCCAGTCGCCGGTGTTCAGCTCGATTCGCGTGAACGTCGGCACGCGGCTGCCCGCGCATGCAACGACGCACGGC
CACGTGCTGATGGGCGACCTGTCGCTGAAGGAATTGCGCGAGCTGTATCCGGAAAGCACGCTGAACCGGATGACGAGCGC
GACGCCGGAGACGGTCGATGCGTTGTACGAAGTGATCCGCGAGGACGCATTGCGCGGCTACGGCGTCAGCAATTCGTCGT
TCGAACGCGGCATTTCAGTGGTCACGGCGCCGGTGCGCAACGACACGCAGAAGATCGTCGCGTGCATCACGGTGACTGTG
CCTCGGCCGGAGATCGACGCGGCGCTGATCGCCGACGGCCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAGCTGTCGCG
GCGGCTCAATTACCGCTCGGATGACGAGCACACGTTTATGAAGGCTTTGGGATTGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4C074

Antitoxin

Source ID Structure
AlphaFold DB A0A1B4C064

References