Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1188553..1190309 Replicon chromosome
Accession NZ_CP013361
Organism Burkholderia thailandensis strain 2003015869

Toxin (Protein)


Gene name doc Uniprot ID Q2T555
Locus tag WI24_RS22470 Protein ID WP_009900384.1
Coordinates 1188553..1189458 (+) Length 302 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q2T556
Locus tag WI24_RS22475 Protein ID WP_009897321.1
Coordinates 1189455..1190309 (+) Length 285 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WI24_RS22440 1183948..1185036 - 1089 WP_009900389.1 porin -
WI24_RS22445 1185471..1185788 + 318 WP_009897336.1 non-heme iron oxygenase ferredoxin subunit -
WI24_RS22450 1185790..1186101 + 312 WP_009900387.1 hypothetical protein -
WI24_RS22455 1186136..1187203 + 1068 WP_019255252.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
WI24_RS22460 1187200..1187970 + 771 WP_009900385.1 SDR family oxidoreductase -
WI24_RS22465 1188009..1188536 + 528 WP_009897327.1 cupin domain-containing protein -
WI24_RS22470 1188553..1189458 + 906 WP_009900384.1 alpha/beta fold hydrolase Toxin
WI24_RS22475 1189455..1190309 + 855 WP_009897321.1 IclR family transcriptional regulator Antitoxin
WI24_RS22480 1190306..1191103 + 798 WP_009897318.1 SDR family oxidoreductase -
WI24_RS22485 1191096..1192769 + 1674 WP_009900383.1 thiamine pyrophosphate-binding protein -
WI24_RS22490 1192762..1193577 + 816 WP_009897315.1 aspartate dehydrogenase -
WI24_RS22495 1193599..1195089 + 1491 WP_009900381.1 aldehyde dehydrogenase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - bopE / bopA / bicP / bprB / bprD / bprC / tssL-5 / tssK-5 / tssJ-5 / tagD-5 / tagC-5 / tagB-5 / tagAB-5 / tssI-5 / tssH-5/clpV / tssG-5 / tssF-5 / tssE-5 / tssC-5 / tssB-5 / bimA / pmlI/bspI1 / pmlR/bspR1 1057536..1429212 371676


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(54-285)

Antitoxin

(143-265)


Sequences


Toxin        


Download         Length: 302 a.a.        Molecular weight: 30752.67 Da        Isoelectric Point: 8.4768

>T58498 WP_009900384.1 NZ_CP013361:1188553-1189458 [Burkholderia thailandensis]
MSAISTTTTDASATPFAALLERFAERRAAAGGARTIGYREAGAAYAAHAGRDPVVLLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGVSSRVAADSPVASDYAASLAAWLDALRIERCVLVGHSLGAIVAGAFARQAGERLSGLLLISPAGGYGGAPA
DVRAERRDSRLALLASLGPQGLAAERSANMLSAQASDAARAWVRWNMARIVPAGYAQATHLLANADLASDLAHYRGRVAV
AVGADDTITPPAACERIARAAGAGLQVIPRAGHAGYVEAPDAYNALIDAFCRQCDGSRGAA

Download         Length: 906 bp

>T58498 NZ_CP013361:1188553-1189458 [Burkholderia thailandensis]
ATGAGCGCAATCTCCACGACGACTACCGATGCGAGCGCGACGCCGTTCGCCGCGCTGCTCGAACGCTTTGCCGAGCGGCG
CGCGGCCGCGGGCGGCGCGCGTACGATCGGCTATCGCGAAGCGGGCGCGGCGTACGCCGCGCATGCCGGGCGCGATCCCG
TCGTGTTGCTGCACGGGATCGGATCGGGTGCGGCGTCGTGGGTGCGTCAACTCGATGCGCTCGGCGCGACGCGTCGCGCG
CTCGCGTGGGACGCGCCCGGCTATGGCGTCTCGTCGCGCGTCGCGGCCGATTCGCCTGTCGCATCCGACTACGCGGCGTC
GCTCGCCGCGTGGCTAGACGCGCTGCGGATCGAACGCTGCGTGCTCGTCGGCCATTCGCTCGGCGCGATCGTCGCCGGCG
CGTTCGCGCGGCAAGCGGGCGAGCGTCTTTCGGGATTGCTGCTGATTTCTCCGGCGGGCGGCTACGGCGGCGCACCCGCC
GACGTGCGGGCCGAGCGGCGCGACAGCCGCCTCGCGCTGCTCGCGTCGCTCGGCCCGCAAGGGCTCGCCGCCGAGCGCAG
CGCAAACATGCTGTCCGCGCAGGCGAGCGACGCCGCGCGCGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCCGCCG
GCTATGCGCAGGCGACGCACCTGCTCGCGAACGCGGACCTCGCTTCCGATCTCGCGCATTATCGCGGCCGCGTCGCGGTC
GCGGTCGGCGCCGACGATACGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCGCGGGCAGCGGGCGCCGGGTTGCAGGT
GATCCCGCGCGCGGGCCATGCCGGCTATGTCGAAGCGCCGGATGCATACAACGCGTTGATCGACGCATTTTGCCGTCAAT
GCGACGGATCGCGAGGTGCGGCATGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31148.57 Da        Isoelectric Point: 6.9978

>AT58498 WP_009897321.1 NZ_CP013361:1189455-1190309 [Burkholderia thailandensis]
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIEGLRDATGFTAHIVIRDGRDVVFVAKAQNAGHAFGSVRVNVGTRLPAHATTHGHV
LMGDLTLAELRTLYPERALERVTKATPETVDALFDVIRADARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDASLVADGLIDKVVRAAAELSRRLNYRSDDENTYLKALGLR

Download         Length: 855 bp

>AT58498 NZ_CP013361:1189455-1190309 [Burkholderia thailandensis]
ATGAGCGAGCCGCTGCTGAAGGACGCCGACGACGCGCGCAACGATTCGAACTACGTCGTGCCTGGGCTCGAGCGCGGGCT
GCGGATCCTCGCCGAGTTCTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAGCTGTCGAAGCGGCTCGGCATTCCGCGCA
CGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTGGGCTTTCTCGAGCGCGCGGACAAGGATCGCAACTATCGCCTC
GGCGTCGCGGTGCTGCGCCTCGGCTTCGAATACCTGAGCTCGCTCGAGCTGACCGATCTCGGTTTGCCGGTGATCGAGGG
CTTGCGCGACGCGACGGGCTTCACGGCGCACATCGTGATCCGCGACGGCCGCGATGTCGTGTTCGTCGCGAAGGCGCAAA
ACGCGGGGCACGCGTTCGGCTCGGTGCGGGTGAACGTCGGCACGCGCCTGCCCGCGCACGCGACGACGCACGGCCACGTG
CTGATGGGCGACTTGACGCTCGCCGAGTTGCGCACGCTGTATCCGGAGCGGGCGCTCGAACGCGTGACGAAGGCGACGCC
CGAGACCGTCGATGCGCTGTTCGACGTGATCCGTGCCGACGCGCGCCGCGGCTACGGCATCGGCAACTCGGCGTTCGAGC
GCGACATCTCGGTCGTCACGGCGCCCGTGCGCAACGAGGCGAGCCGGATCGTCGCAGTCGTCACGGTGACGGTGCCGAGG
CCGGAGATCGATGCGTCGCTCGTCGCCGACGGGCTGATCGACAAGGTCGTGCGTGCGGCGGCCGAGCTGTCTCGGCGGCT
CAATTACCGGTCCGACGACGAAAACACCTACTTGAAGGCATTGGGATTGCGATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB Q2T555


Antitoxin

Source ID Structure
AlphaFold DB Q2T556

References