Detailed information of TA system TA058496

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 987328..989108
• Replicon: chromosome
• Accession: NZ_CP013359
• Organism: Burkholderia oklahomensis C6786

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A7U4USQ6
• Locus tag: WI23_RS24700
• Protein ID: WP_010119621.1
• Coordinates: 987328..988677 (-)
• Length: 450 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: WI23_RS24705
• Protein ID: WP_010109597.1
• Coordinates: 988674..989108 (-)
• Length: 145 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WI23_RS24680	982539..983939	-	1401	WP_010119624.1	hypothetical protein	-
WI23_RS24685	984364..985317	-	954	WP_010109604.1	agmatinase	-
WI23_RS24690	985470..986384	+	915	WP_010119622.1	LysR family transcriptional regulator	-
WI23_RS24695	986620..987063	+	444	WP_010109600.1	hypothetical protein	-
WI23_RS24700	987328..988677	-	1350	WP_010119621.1	type II toxin-antitoxin system HipA family toxin	Toxin
WI23_RS24705	988674..989108	-	435	WP_010109597.1	helix-turn-helix domain-containing protein	Antitoxin
WI23_RS34175	989179..989379	-	201	WP_124072353.1	hypothetical protein	-
WI23_RS34765	989416..989624	-	209	Protein_881	hypothetical protein	-
WI23_RS24715	990081..992453	+	2373	WP_107950947.1	cellulose biosynthesis cyclic di-GMP-binding regulatory protein BcsB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (12-112)

Antitoxin

• Cro/C1-type helix-turn-helix domain (22-71)

Sequences

Toxin

Protein

• Length: 450 a.a.
• Molecular weight: 49795.74 Da
• Isoelectric Point: 9.0373

>T58496 WP_010119621.1 NZ_CP013359:c988677-987328 [Burkholderia oklahomensis C6786]
VSARRGTRTARLHLWMNGLPVGYWEHARDGERLVYFDEWIADPQGRPLSLSLPFTPGNQPYRGRLVSDYFDNLLPDSEPI
RRRIAMRYRTGGTSPFELLSTLGRDCVGALQMLPPGETPDDLERTRGRALADADIARLLREITSAPQAGQHEPLDDLRLS
IAGAQEKTALLRHRGRWLLPEGSTPTTHILKLPLGLVGNRRADMRTSVENEWLCSKIVAAYGLPVAHCDIAHFDDQKALV
VERFDRKPSSDARWILRLPQEDMCQATGTSAFDKYQADGGPGIEAIMDVLAGSEHAADRYAFFATQIVFWLLAATDGHAK
NFSIAHLPGNRFRSTPLYDVLSAHPVIGRGANQLPMQRARLAMGVRGKNIHYPINQIQRRHWIAQGQRVGFAPAEVDDMI
VALTARTAGVVDEVSARLPRDFPRDVADAVFSGMLRLNAKLAASSPARA

Nucleotide

• Length: 1350 bp

>T58496 NZ_CP013359:c988677-987328 [Burkholderia oklahomensis C6786]
GTGAGCGCGCGCCGCGGCACGCGCACGGCGCGCCTGCATCTGTGGATGAACGGCCTGCCCGTCGGCTACTGGGAGCATGC
CCGCGACGGCGAGCGCCTCGTCTACTTCGACGAATGGATCGCGGACCCGCAAGGCCGCCCGCTGTCGCTTTCGCTGCCGT
TCACGCCGGGCAACCAGCCGTATCGCGGCCGGCTCGTCAGCGACTACTTCGACAACCTGCTGCCCGACAGCGAACCGATC
CGGCGCCGGATCGCGATGCGCTACAGGACGGGCGGCACGTCGCCGTTCGAGCTGCTCTCGACGCTCGGCCGCGATTGCGT
CGGCGCGCTGCAGATGCTGCCGCCCGGCGAAACGCCGGACGATCTCGAGCGCACCCGCGGCCGCGCGCTCGCCGACGCGG
ACATCGCGCGCCTGCTGCGCGAGATCACGTCCGCGCCGCAAGCCGGGCAGCACGAGCCGCTCGACGATCTGCGCCTGTCG
ATCGCGGGCGCGCAGGAAAAGACCGCGCTGCTGCGCCATCGCGGCCGGTGGCTGCTGCCCGAAGGCAGCACGCCGACCAC
GCATATCCTGAAGCTGCCGCTCGGGCTCGTCGGCAACCGGCGCGCCGACATGCGCACGTCGGTCGAGAACGAATGGCTGT
GCTCGAAGATCGTCGCCGCGTACGGGCTGCCCGTCGCGCATTGCGACATCGCGCATTTCGACGATCAGAAGGCGCTCGTC
GTCGAGCGCTTCGACCGCAAGCCGTCGAGCGACGCGCGCTGGATCCTGCGCCTGCCGCAGGAAGACATGTGCCAGGCGAC
GGGCACGTCCGCATTCGACAAATATCAGGCCGACGGCGGACCGGGCATCGAGGCGATCATGGACGTGCTCGCCGGCTCCG
AGCACGCGGCGGACCGCTACGCATTCTTCGCGACGCAAATCGTGTTCTGGCTGCTCGCCGCGACCGACGGCCACGCGAAG
AACTTCAGCATCGCGCATCTGCCGGGCAATCGCTTTCGATCGACGCCGCTTTACGACGTGCTGTCCGCGCATCCGGTGAT
CGGTCGGGGTGCCAATCAATTGCCGATGCAGCGCGCGCGGCTCGCGATGGGCGTGCGCGGCAAGAACATCCACTATCCGA
TCAACCAGATCCAGCGGCGGCATTGGATCGCGCAGGGCCAGCGCGTCGGCTTCGCGCCCGCCGAGGTCGACGACATGATC
GTTGCATTGACCGCGCGAACCGCGGGCGTCGTCGACGAAGTGTCGGCGCGCCTGCCGCGCGATTTTCCGCGGGACGTCGC
CGATGCGGTCTTCAGCGGGATGCTGCGTCTGAACGCGAAGCTCGCCGCGTCATCGCCGGCGCGAGCGTAG

Antitoxin

Protein

• Length: 145 a.a.
• Molecular weight: 15552.15 Da
• Isoelectric Point: 11.9043

>AT58496 WP_010109597.1 NZ_CP013359:c989108-988674 [Burkholderia oklahomensis C6786]
MAITIEHEIKTLGQLRPILRGFRKAAGLTQAMLASRLGVTQQTYAQFEANPASASVERLFKVLRVLDVELTLTLTHVYVA
PAKPAAKQTVAAPARKAVKTVGSGRVAAKRPASPTSQSAPGPHAAERLPRSPRKRAAPKKREDW

Nucleotide

• Length: 435 bp

>AT58496 NZ_CP013359:c989108-988674 [Burkholderia oklahomensis C6786]
ATGGCCATCACCATCGAACACGAGATCAAGACGCTCGGCCAATTGCGGCCGATCCTGCGCGGCTTCCGCAAGGCGGCCGG
ATTGACGCAGGCGATGCTCGCGAGCCGCCTCGGCGTCACGCAGCAGACCTATGCGCAATTCGAGGCGAACCCGGCGTCGG
CGAGCGTCGAGCGGCTGTTCAAGGTGCTGCGCGTCCTCGATGTCGAACTCACGCTCACGCTGACCCATGTCTACGTCGCG
CCCGCCAAGCCCGCCGCGAAGCAGACGGTCGCCGCGCCCGCGCGCAAAGCCGTGAAAACGGTCGGAAGCGGACGCGTCGC
CGCAAAGCGCCCCGCGTCGCCGACGAGCCAATCCGCGCCCGGCCCGCATGCCGCCGAGCGCCTGCCCCGCTCGCCTCGCA
AGCGCGCCGCCCCGAAGAAGCGGGAGGACTGGTGA

Structures

Toxin

• AlphaFold DB: A0A7U4USQ6