Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1775033..1776780 Replicon chromosome
Accession NZ_CP013356
Organism Burkholderia oklahomensis EO147

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag WG70_RS08215 Protein ID WP_010108748.1
Coordinates 1775884..1776780 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag WG70_RS08210 Protein ID WP_010108749.1
Coordinates 1775033..1775887 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WG70_RS08190 1770243..1771733 - 1491 WP_010108755.1 aldehyde dehydrogenase -
WG70_RS08195 1771765..1772580 - 816 WP_010108754.1 aspartate dehydrogenase -
WG70_RS08200 1772573..1774246 - 1674 WP_041282030.1 thiamine pyrophosphate-binding protein -
WG70_RS08205 1774239..1775036 - 798 WP_010108750.1 SDR family oxidoreductase -
WG70_RS08210 1775033..1775887 - 855 WP_010108749.1 IclR family transcriptional regulator Antitoxin
WG70_RS08215 1775884..1776780 - 897 WP_010108748.1 alpha/beta fold hydrolase Toxin
WG70_RS08220 1776797..1777324 - 528 WP_010108747.1 cupin domain-containing protein -
WG70_RS08225 1777356..1778126 - 771 WP_010118458.1 SDR family oxidoreductase -
WG70_RS08230 1778123..1779190 - 1068 WP_041282028.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
WG70_RS08235 1779225..1779536 - 312 WP_010108743.1 hypothetical protein -
WG70_RS08240 1779538..1779855 - 318 WP_010108742.1 non-heme iron oxygenase ferredoxin subunit -
WG70_RS08245 1780289..1781377 + 1089 WP_010108741.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-280)

Antitoxin

Transcription regulator IclR, N-terminal

(23-71)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30711.76 Da        Isoelectric Point: 7.3485

>T58491 WP_010108748.1 NZ_CP013356:c1776780-1775884 [Burkholderia oklahomensis EO147]
MSAISVTTNDIGATPFAELLERFPERRAAAGAAGAIGYREAGDARGERCPVVLLHGIGSGAASWVRQLDTLGATRRALAW
DAPGYGASSRVAAESPVAADYAASLDAWLDALRIERCVLVGHSLGAIVAGAFARAAGERLSGLLLISPAGGYGSAPADVR
AERRDSRLALLASLGPQGLAEQRSANMLSAHASDAARAWVRWNMARIVPAGYAQATHLLANADLATDLVHYRGRVAVAVG
ADDAITPPAACERIAQAARVGLQVIPRAGHAGYVEAPDAYGALIDAFCRQCDGLRGAA

Download         Length: 897 bp

>T58491 NZ_CP013356:c1776780-1775884 [Burkholderia oklahomensis EO147]
ATGAGCGCGATTTCCGTGACGACGAACGACATCGGCGCGACGCCGTTCGCCGAACTGCTCGAACGCTTTCCCGAGCGGCG
CGCGGCGGCGGGCGCCGCGGGCGCGATCGGTTACCGCGAGGCCGGCGACGCGCGCGGCGAGCGCTGTCCCGTCGTGCTGT
TGCACGGGATCGGGTCGGGTGCGGCGTCGTGGGTGCGGCAGCTCGATACGCTCGGCGCGACGCGCCGTGCGCTCGCGTGG
GACGCGCCCGGCTACGGCGCGTCGTCGCGCGTCGCCGCCGAGTCGCCCGTCGCGGCCGATTACGCAGCGTCGCTCGACGC
ATGGCTCGACGCGCTGCGGATCGAGCGCTGCGTGCTCGTCGGCCACTCGCTCGGCGCGATCGTCGCCGGTGCGTTCGCGC
GCGCCGCGGGCGAGCGTCTTTCAGGATTGCTGTTGATTTCGCCCGCGGGCGGCTATGGCAGCGCGCCCGCCGACGTGCGG
GCCGAGCGGCGCGACAGCCGTCTCGCGCTGCTCGCGTCGCTCGGCCCGCAAGGGCTCGCCGAGCAGCGCAGCGCGAACAT
GCTGTCCGCGCATGCGAGCGACGCGGCGCGCGCATGGGTGCGCTGGAACATGGCGCGGATCGTGCCCGCCGGCTACGCAC
AGGCGACGCACCTGCTCGCGAACGCCGATCTCGCGACCGATCTCGTGCATTACCGCGGCCGCGTCGCGGTCGCGGTCGGC
GCGGACGACGCGATCACGCCGCCCGCAGCATGCGAGCGGATCGCGCAAGCGGCGCGCGTCGGGCTGCAGGTGATCCCGCG
CGCGGGTCACGCGGGCTACGTAGAAGCACCCGATGCGTATGGCGCGCTGATCGACGCGTTTTGCCGTCAGTGCGACGGAC
TGCGAGGTGCGGCATGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 30991.45 Da        Isoelectric Point: 6.6554

>AT58491 WP_010108749.1 NZ_CP013356:c1775887-1775033 [Burkholderia oklahomensis EO147]
MSEPLLKDADDAKNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIEGLRDATGFTTHIVIRDGRDVVFVAKAQNAGHAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAQLCALYPEPALERVTKATPETVDALFSVIRDDARRGYGIGNSAFERDISVVTAPVRNDASKIVAVVTVTVPR
PEIDASLVADGLIDKVLRAAAELSRRLNYRPDDENTYLKALGLR

Download         Length: 855 bp

>AT58491 NZ_CP013356:c1775887-1775033 [Burkholderia oklahomensis EO147]
ATGAGCGAACCGCTGCTGAAAGACGCCGACGACGCGAAAAACGATTCGAACTACGTAGTACCGGGGCTCGAGCGCGGTCT
GCGGATTCTCGCGGAGTTCTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAGCTGTCGAAGCGGCTCGGCATTCCGCGCA
CGACGGTGTTCCGTCTGCTGCAAACGCTCGAATCGCTCGGTTTTCTCGAGCGCGCGGACAAGGATCGCAATTATCGATTG
GGCGTCGCGGTGCTGCGCCTCGGCTTCGAATACCTGAGCTCGCTCGAGCTGACCGATCTCGGCTTGCCGGTGATCGAAGG
CCTGCGTGACGCGACGGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTCGTGTTCGTCGCGAAGGCGCAGA
ATGCGGGGCACGCGTTCGGCTCGGTGCGGGTGAACGTCGGCACGCGCTTGCCCGCGCATGCGACGACGCACGGCCACGTG
CTGATGGGCGACCTGTCGCTCGCTCAGTTATGCGCGCTGTATCCGGAGCCGGCGCTCGAGCGCGTGACGAAGGCGACGCC
CGAGACCGTCGACGCGCTCTTCAGCGTGATCCGCGACGACGCGCGGCGCGGCTACGGGATCGGCAACTCGGCGTTCGAGC
GCGACATCTCGGTCGTCACGGCGCCGGTGCGCAACGACGCGAGCAAGATCGTCGCCGTCGTCACGGTGACGGTGCCGCGG
CCGGAGATCGACGCGTCGCTCGTCGCCGACGGGCTGATCGACAAGGTGCTGCGCGCGGCGGCGGAGCTGTCGCGGCGGCT
GAACTACCGGCCCGACGACGAAAACACCTATTTGAAGGCATTGGGATTGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References