Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1009363..1011143 Replicon chromosome
Accession NZ_CP013356
Organism Burkholderia oklahomensis EO147

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag WG70_RS04790 Protein ID WP_010109598.1
Coordinates 1009363..1010712 (-) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag WG70_RS04795 Protein ID WP_010109597.1
Coordinates 1010709..1011143 (-) Length 145 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WG70_RS04770 1004565..1005965 - 1401 WP_010109605.1 hypothetical protein -
WG70_RS35550 1005965..1006132 - 168 WP_162474159.1 hypothetical protein -
WG70_RS04775 1006387..1007340 - 954 WP_010109604.1 agmatinase -
WG70_RS04780 1007493..1008407 + 915 WP_010109602.1 LysR family transcriptional regulator -
WG70_RS04785 1008643..1009086 + 444 WP_010109600.1 hypothetical protein -
WG70_RS04790 1009363..1010712 - 1350 WP_010109598.1 type II toxin-antitoxin system HipA family toxin Toxin
WG70_RS04795 1010709..1011143 - 435 WP_010109597.1 helix-turn-helix domain-containing protein Antitoxin
WG70_RS34815 1011214..1011414 - 201 WP_124072353.1 hypothetical protein -
WG70_RS04800 1011583..1011893 - 311 Protein_911 hypothetical protein -
WG70_RS04805 1012115..1014487 + 2373 WP_041282198.1 cellulose biosynthesis cyclic di-GMP-binding regulatory protein BcsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(12-112)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-71)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 49883.80 Da        Isoelectric Point: 8.7644

>T58490 WP_010109598.1 NZ_CP013356:c1010712-1009363 [Burkholderia oklahomensis EO147]
VSARRGTRTARLHLWMNGLPVGYWEHARDGERLVYFDEWIADPQGRPLSLSLPFTPGNQPYRGRLVSDYFDNLLPDSEPI
RRRIAMRYRTGGTSPFELLSTLGRDCVGALQMLPPGETPDDLERIRGRALADADIARLLREITSAPQAGQHEPLDDLRLS
IAGAQEKTALLRHRGRWLLPEGSTPTTHILKLPLGLVGNRRADMRTSVENEWLCSKIVAAYGLPVAHCDIAHFDDQKALV
VERFDRKPSSDARWILRLPQEDMCQATGTSAFDKYQADGGPGIEAIMDVLAGSEHTADRYAFFATQIVFWLLAATDGHAK
NFSIAHLPGNRFRSTPLYDVLSAHPVIGRGANQLPMQRARLAMGVRGKNIHYPINQIQRRHWIAQGQRVGFAPAEVDDMI
DALTARTAGVVDEVSARLPRDFPRDVADAVFSGMLRLNAKLAASSPTRA

Download         Length: 1350 bp

>T58490 NZ_CP013356:c1010712-1009363 [Burkholderia oklahomensis EO147]
GTGAGCGCGCGCCGCGGCACGCGCACGGCGCGCCTGCATCTGTGGATGAACGGCCTGCCCGTCGGCTACTGGGAGCATGC
CCGCGACGGCGAGCGCCTCGTCTACTTCGACGAATGGATCGCGGACCCGCAAGGCCGCCCGCTGTCGCTTTCGCTGCCGT
TCACGCCGGGCAACCAGCCGTATCGCGGCCGGCTCGTCAGCGACTACTTCGACAACCTGCTGCCCGACAGCGAACCGATC
CGGCGCCGGATCGCGATGCGCTACAGGACGGGCGGCACGTCGCCGTTCGAGCTGCTCTCGACGCTCGGCCGCGATTGCGT
CGGCGCGCTGCAGATGCTGCCGCCCGGCGAAACGCCGGACGATCTCGAGCGCATCCGCGGCCGCGCGCTCGCCGACGCGG
ACATCGCGCGCCTGCTGCGCGAGATCACGTCCGCGCCGCAAGCCGGGCAGCACGAGCCGCTCGACGATCTGCGCCTGTCG
ATCGCGGGCGCGCAGGAAAAGACCGCGCTGCTGCGCCATCGCGGCCGGTGGCTGCTGCCCGAAGGCAGCACGCCGACCAC
GCATATCCTGAAGCTGCCGCTCGGGCTCGTCGGCAACCGGCGCGCCGACATGCGCACGTCGGTCGAGAACGAATGGCTGT
GCTCGAAGATCGTCGCCGCGTACGGGCTGCCCGTCGCGCATTGCGACATCGCGCATTTCGACGATCAGAAGGCGCTCGTC
GTCGAGCGCTTCGACCGCAAGCCGTCGAGCGACGCGCGCTGGATCCTGCGCCTGCCGCAGGAAGACATGTGCCAGGCGAC
GGGCACGTCCGCATTCGACAAATATCAGGCCGACGGCGGACCGGGCATCGAGGCGATCATGGACGTGCTCGCCGGCTCCG
AGCACACGGCGGACCGCTACGCATTCTTCGCGACGCAAATCGTGTTCTGGCTGCTCGCCGCGACCGACGGCCACGCGAAG
AACTTCAGCATCGCGCATCTGCCGGGCAATCGCTTTCGATCGACGCCGCTTTACGACGTGCTGTCCGCGCATCCGGTGAT
CGGTCGGGGTGCCAATCAATTGCCGATGCAGCGCGCGCGGCTCGCGATGGGCGTGCGCGGCAAGAACATCCACTATCCGA
TCAACCAGATCCAGCGGCGGCATTGGATCGCGCAGGGCCAGCGCGTCGGCTTCGCGCCCGCCGAGGTCGACGACATGATC
GATGCATTGACCGCGCGAACCGCGGGCGTCGTCGACGAAGTGTCGGCGCGCCTGCCGCGCGATTTTCCGCGGGACGTCGC
CGATGCGGTCTTCAGCGGGATGCTGCGTCTGAACGCGAAGCTCGCCGCGTCATCGCCGACGCGAGCGTAG

Antitoxin


Download         Length: 145 a.a.        Molecular weight: 15552.15 Da        Isoelectric Point: 11.9043

>AT58490 WP_010109597.1 NZ_CP013356:c1011143-1010709 [Burkholderia oklahomensis EO147]
MAITIEHEIKTLGQLRPILRGFRKAAGLTQAMLASRLGVTQQTYAQFEANPASASVERLFKVLRVLDVELTLTLTHVYVA
PAKPAAKQTVAAPARKAVKTVGSGRVAAKRPASPTSQSAPGPHAAERLPRSPRKRAAPKKREDW

Download         Length: 435 bp

>AT58490 NZ_CP013356:c1011143-1010709 [Burkholderia oklahomensis EO147]
ATGGCCATCACCATCGAACACGAGATCAAGACGCTCGGCCAATTGCGGCCGATCCTGCGCGGCTTCCGCAAGGCGGCCGG
ATTGACGCAGGCGATGCTCGCGAGCCGCCTCGGCGTCACGCAGCAGACCTATGCGCAATTCGAGGCGAACCCGGCGTCGG
CGAGCGTCGAGCGGCTGTTCAAGGTGCTGCGCGTCCTCGATGTCGAACTCACGCTCACGCTGACCCATGTCTACGTCGCG
CCCGCCAAGCCCGCCGCGAAGCAGACGGTCGCCGCGCCCGCGCGCAAAGCCGTGAAAACGGTCGGAAGCGGACGCGTCGC
CGCAAAGCGCCCCGCGTCGCCGACGAGCCAATCCGCGCCCGGCCCGCATGCCGCCGAGCGCCTGCCCCGCTCGCCGCGCA
AGCGCGCCGCCCCGAAGAAGCGGGAGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References