58489

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 2037272..2037813 Replicon chromosome
Accession NZ_CP013355
Organism Lutibacter profundi strain LP1

Toxin (Protein)


Gene name parE Uniprot ID A0A0X8G7D0
Locus tag Lupro_RS09000 Protein ID WP_068209003.1
Coordinates 2037272..2037574 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0X8G7B9
Locus tag Lupro_RS09005 Protein ID WP_068209005.1
Coordinates 2037571..2037813 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Lupro_RS08975 2032279..2032689 - 411 WP_068208991.1 hypothetical protein -
Lupro_RS08980 2032773..2033189 - 417 WP_144439127.1 hypothetical protein -
Lupro_RS08985 2033393..2033698 - 306 WP_068208997.1 hypothetical protein -
Lupro_RS08990 2033893..2034693 - 801 WP_068208999.1 response regulator -
Lupro_RS08995 2034700..2036703 - 2004 WP_068209001.1 tetratricopeptide repeat protein -
Lupro_RS09000 2037272..2037574 - 303 WP_068209003.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Lupro_RS09005 2037571..2037813 - 243 WP_068209005.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
Lupro_RS09010 2038331..2038804 + 474 WP_068209008.1 hypothetical protein -
Lupro_RS09015 2038840..2039412 + 573 WP_068209010.1 YceI family protein -
Lupro_RS09020 2039533..2040459 + 927 WP_068209013.1 patatin-like phospholipase family protein -
Lupro_RS09025 2040488..2042026 + 1539 WP_068209015.1 FMN-binding glutamate synthase family protein -
Lupro_RS13545 2042581..2042745 - 165 WP_158499560.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-94)

Antitoxin

Antitoxin ParD

(1-77)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 12196.11 Da        Isoelectric Point: 9.9514

>T58489 WP_068209003.1 NZ_CP013355:c2037574-2037272 [Lutibacter profundi]
MNKNKYRISEQAIKDLNAIWIYTLNKWSKEQADRYYDLIIGEIEFISDKFLTGKSAEQTRKNYRVTKIKSHLIFYRKIEN
DIVEVIRILHQRMDIKERLD

Download         Length: 303 bp

>T58489 NZ_CP013355:c2037574-2037272 [Lutibacter profundi]
ATGAATAAAAACAAATATCGCATAAGTGAACAGGCGATTAAAGACTTAAATGCCATTTGGATTTATACATTAAATAAATG
GTCTAAAGAACAAGCTGATAGATATTACGACTTAATAATTGGAGAAATTGAGTTTATTTCTGACAAATTTTTGACTGGAA
AATCAGCAGAGCAAACACGAAAAAATTATAGAGTGACTAAAATAAAATCACATTTGATTTTTTATAGAAAAATAGAAAAC
GACATTGTGGAAGTAATAAGAATTTTGCATCAAAGAATGGATATAAAAGAACGACTAGATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9252.56 Da        Isoelectric Point: 8.5258

>AT58489 WP_068209005.1 NZ_CP013355:c2037813-2037571 [Lutibacter profundi]
MGKNTSISIGNHFEEFIQNEVKSGKYGSVSEVIRSALRLLEREETKEKELIKALKIGEKSGFIENFNPKENLKELHRQYL

Download         Length: 243 bp

>AT58489 NZ_CP013355:c2037813-2037571 [Lutibacter profundi]
ATGGGAAAAAACACATCAATATCAATCGGTAATCATTTCGAGGAATTTATTCAAAATGAGGTTAAATCTGGAAAATATGG
CTCTGTAAGCGAAGTTATTCGCTCTGCTTTGAGACTTCTTGAAAGAGAAGAGACTAAGGAAAAAGAACTAATTAAAGCTT
TGAAAATAGGGGAAAAAAGTGGATTTATTGAAAATTTCAACCCCAAAGAAAATTTGAAAGAATTACACCGACAATATTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X8G7D0

Antitoxin

Source ID Structure
AlphaFold DB A0A0X8G7B9

References