Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 107644..109196 Replicon chromosome
Accession NZ_CP013342
Organism Sphingopyxis terrae subsp. terrae NBRC 15098 strain 203-1

Toxin (Protein)


Gene name HipA1 Uniprot ID A0A142VTP7
Locus tag AOA14_RS00505 Protein ID WP_062900402.1
Coordinates 107644..108978 (-) Length 445 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag AOA14_RS00510 Protein ID WP_062902936.1
Coordinates 108981..109196 (-) Length 72 a.a.

Genomic Context

AOA14_RS19005AOA14_RS00515AOA14_RS00520AOA14_RS00525AOA14_RS00475AOA14_RS00480AOA14_RS00485AOA14_RS00490AOA14_RS00495AOA14_RS00500AOA14_RS00505AOA14_RS00510
Location: 109382..109800 (419 bp)
Type: Others
Protein ID: Protein_99
Location: 110301..110546 (246 bp)
Type: Others
Protein ID: WP_062900403.1
Location: 110731..111873 (1143 bp)
Type: Others
Protein ID: WP_202988343.1
Location: 112071..113480 (1410 bp)
Type: Others
Protein ID: WP_082819769.1
Location: 102846..103676 (831 bp)
Type: Others
Protein ID: WP_062900396.1
Location: 104075..105004 (930 bp)
Type: Others
Protein ID: WP_062900397.1
Location: 105068..105241 (174 bp)
Type: Others
Protein ID: WP_202988342.1
Location: 105417..106157 (741 bp)
Type: Others
Protein ID: WP_062900399.1
Location: 106129..106503 (375 bp)
Type: Others
Protein ID: WP_062900400.1
Location: 106751..107647 (897 bp)
Type: Others
Protein ID: WP_062900401.1
Location: 107644..108978 (1335 bp)
Type: Toxin
Protein ID: WP_062900402.1
Location: 108981..109196 (216 bp)
Type: Antitoxin
Protein ID: WP_062902936.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AOA14_RS00475102846..103676-831WP_062900396.123S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ-
AOA14_RS00480104075..105004-930WP_062900397.1HEPN domain-containing protein-
AOA14_RS00485105068..105241-174WP_202988342.1hypothetical protein-
AOA14_RS00490105417..106157-741WP_062900399.1RES family NAD+ phosphorylase-
AOA14_RS00495106129..106503-375WP_062900400.1MbcA/ParS/Xre antitoxin family protein-
AOA14_RS00500106751..107647-897WP_062900401.1HNH endonuclease-
AOA14_RS00505107644..108978-1335WP_062900402.1type II toxin-antitoxin system HipA family toxinToxin
AOA14_RS00510108981..109196-216WP_062902936.1helix-turn-helix domain-containing proteinAntitoxin
AOA14_RS19005109382..109800+419Protein_99DUF2384 domain-containing protein-
AOA14_RS00515110301..110546+246WP_062900403.1helix-turn-helix domain-containing protein-
AOA14_RS00520110731..111873+1143WP_202988343.1hypothetical protein-
AOA14_RS00525112071..113480+1410WP_082819769.1AAA family ATPase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(141-372)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-44)


Sequences

Toxin        


Download         Length: 445 a.a.        Molecular weight: 47548.91 Da        Isoelectric Point: 5.0917

>T58481 WP_062900402.1 NZ_CP013342:c108978-107644 [Sphingopyxis terrae subsp. terrae NBRC 15098]
VDLPVHYEDRLVATISADAQTTRLAYADAWGSSADSFPVSLAMPIRPEPYEGGQVLPWLMNLLPEGEPLRAMTRALGAAP
EDALGLIAQTGNDLAGALSIAPQRPRGEPGYRPIPDTGALERIIEELPARPFLVGEDGVSMSLAGAQEKLPVAVIDGQIA
VPINGAPSTHILKPDNPRLPGSVHNEALCMLLARRIGLNVAPVTTGVAGERSYLLVERYDRTGTGNNVRRLHQEDFCQAL
GSPPAAKYEFNGTGMRGPSIADMFAVVREHMTARDITRLLDAVIFNIAIGNVDSHAKNYSILLGPGAPQLAPLYDLMSGL
AWTNITQNHAQAIGEQRRGRHIYGRHWRRMADAAGLAARGTVQRVEQVTARLLRELPAAVEEVASMPAGSSMLEVFAKEI
EERATEVRGHAEKEGLPDTAEVPTDDVPTIGASAYSADREAGAS

Download         Length: 1335 bp

>T58481 NZ_CP013342:c108978-107644 [Sphingopyxis terrae subsp. terrae NBRC 15098]
GTGGACCTTCCGGTTCACTATGAAGACCGCCTGGTCGCCACGATCAGCGCCGATGCGCAGACAACCCGCCTTGCCTATGC
GGATGCCTGGGGTTCATCCGCTGACAGCTTCCCTGTCTCGCTGGCCATGCCGATCCGGCCAGAGCCCTATGAGGGGGGCC
AAGTTCTTCCCTGGCTGATGAACCTCCTGCCGGAGGGCGAACCGTTGCGCGCCATGACGCGCGCGCTAGGCGCTGCACCG
GAGGACGCGCTCGGCCTGATCGCACAGACCGGCAACGATCTGGCAGGCGCGCTCAGCATCGCTCCGCAGCGGCCGCGCGG
CGAGCCCGGCTATCGCCCGATCCCGGATACCGGTGCACTGGAACGGATCATCGAGGAACTGCCAGCGCGGCCATTCCTGG
TCGGCGAGGACGGCGTCTCGATGAGCCTCGCCGGCGCGCAGGAAAAGCTGCCGGTGGCTGTCATCGACGGCCAGATTGCG
GTGCCGATCAACGGCGCGCCATCCACCCATATCCTAAAGCCCGACAATCCACGCCTACCCGGCAGCGTCCACAATGAAGC
GCTATGCATGCTTCTCGCCCGCCGCATCGGCCTCAATGTCGCGCCGGTGACAACGGGCGTTGCAGGGGAACGCAGCTACC
TGCTGGTCGAGCGCTATGACCGGACGGGTACTGGCAACAATGTCCGCCGCCTGCATCAGGAGGATTTCTGTCAGGCACTC
GGCAGCCCGCCTGCCGCCAAGTATGAATTCAACGGCACCGGAATGCGCGGCCCCTCGATCGCCGACATGTTCGCGGTTGT
CCGCGAGCATATGACGGCGCGCGACATCACCCGGCTGCTGGACGCCGTGATCTTCAATATCGCCATCGGCAACGTGGACT
CACACGCAAAGAACTACTCGATCCTGCTCGGCCCAGGTGCCCCGCAGCTTGCTCCGCTCTACGACCTGATGTCGGGCCTC
GCCTGGACCAACATCACCCAGAACCACGCCCAAGCGATCGGCGAGCAGCGCCGCGGCCGCCACATCTACGGTCGCCACTG
GCGGCGCATGGCCGACGCCGCAGGCCTGGCAGCGCGGGGAACGGTGCAGAGGGTGGAGCAGGTGACGGCACGGTTGCTGC
GCGAATTGCCCGCAGCGGTCGAGGAGGTGGCATCTATGCCAGCAGGTTCGTCGATGCTGGAGGTCTTCGCAAAAGAGATC
GAGGAGCGGGCAACAGAAGTCAGGGGACACGCCGAAAAGGAAGGCCTGCCCGACACCGCTGAAGTGCCTACGGACGACGT
GCCGACGATAGGCGCAAGCGCCTATTCTGCTGACAGGGAAGCGGGAGCGTCATGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7209.34 Da        Isoelectric Point: 10.7685

>AT58481 WP_062902936.1 NZ_CP013342:c109196-108981 [Sphingopyxis terrae subsp. terrae NBRC 15098]
MIDNATQFGAAVASARKALGLTQRELALTINSGERFIVDLEAGKPTAQLGKALAAAKAVGLRLTATGISQA

Download         Length: 216 bp

>AT58481 NZ_CP013342:c109196-108981 [Sphingopyxis terrae subsp. terrae NBRC 15098]
ATGATTGACAACGCAACCCAATTCGGCGCAGCCGTCGCCTCGGCCCGCAAGGCCCTTGGCCTTACCCAGCGGGAGCTGGC
GCTCACCATCAACAGCGGCGAGCGCTTCATCGTCGATCTGGAAGCAGGCAAGCCCACCGCCCAACTCGGGAAGGCACTCG
CCGCCGCAAAGGCTGTCGGCTTGCGGCTCACCGCAACCGGCATTTCGCAGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A142VTP7

Antitoxin

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Source
ID
Structure
No matching records found

References