Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 2882163..2882710 Replicon chromosome
Accession NZ_CP013341
Organism Nitrosomonas ureae strain Nm10

Toxin (Protein)


Gene name parE Uniprot ID A0A1H2G1A8
Locus tag ATY38_RS13430 Protein ID WP_062559734.1
Coordinates 2882163..2882465 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1H2G1B4
Locus tag ATY38_RS13435 Protein ID WP_062559735.1
Coordinates 2882462..2882710 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ATY38_RS13405 2877251..2880754 + 3504 WP_062560221.1 DNA polymerase III subunit alpha -
ATY38_RS13425 2881613..2882050 - 438 WP_062559212.1 IS200/IS605 family transposase -
ATY38_RS13430 2882163..2882465 - 303 WP_062559734.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ATY38_RS13435 2882462..2882710 - 249 WP_062559735.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
ATY38_RS13440 2883296..2885559 + 2264 Protein_2665 CRISPR-associated helicase Cas3' -
ATY38_RS13445 2885581..2886264 + 684 WP_062559736.1 type I-C CRISPR-associated protein Cas5 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-91)

Antitoxin

Antitoxin ParD

(3-65)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11780.63 Da        Isoelectric Point: 9.3656

>T58480 WP_062559734.1 NZ_CP013341:c2882465-2882163 [Nitrosomonas ureae]
MTFTIKITPRAQQDLKNIGRYTLQKWGKKKRDSYLRDLDRCFRWLAGNPKIGKHRIDIEEGYYCYLQGSHLIFYTIGESC
IHIIGIPHQAMGVLNYFDPD

Download         Length: 303 bp

>T58480 NZ_CP013341:c2882465-2882163 [Nitrosomonas ureae]
ATGACATTCACCATCAAAATTACTCCACGTGCACAACAAGACCTCAAAAATATTGGGCGTTATACGTTACAAAAATGGGG
TAAAAAGAAACGAGATAGCTATTTGCGCGATCTTGACCGATGTTTCAGGTGGCTAGCTGGAAATCCTAAAATAGGTAAAC
ACAGGATTGATATCGAAGAAGGCTACTACTGTTATTTGCAAGGATCACATTTGATATTCTACACAATTGGTGAGAGCTGT
ATTCACATCATCGGCATACCGCACCAAGCTATGGGTGTATTAAACTACTTTGATCCAGATTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9378.60 Da        Isoelectric Point: 4.6244

>AT58480 WP_062559735.1 NZ_CP013341:c2882710-2882462 [Nitrosomonas ureae]
MATTSLSLGEHWEIFIKNEIASGRYGSASEVVREALRGMEERKSKLEALRIYLKEGVEQAERGEFVKDYSIDKIIEELDA
KE

Download         Length: 249 bp

>AT58480 NZ_CP013341:c2882710-2882462 [Nitrosomonas ureae]
ATGGCAACGACAAGTTTGAGTTTAGGCGAGCATTGGGAAATATTTATTAAAAATGAGATCGCAAGCGGACGGTATGGCTC
GGCGAGTGAAGTCGTTCGCGAGGCATTACGTGGAATGGAAGAGCGCAAAAGCAAGCTGGAAGCTCTTCGCATATATTTAA
AAGAAGGTGTGGAACAAGCTGAGCGTGGTGAATTCGTAAAAGATTATTCTATTGATAAGATTATTGAGGAGTTGGATGCA
AAGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H2G1A8

Antitoxin

Source ID Structure
AlphaFold DB A0A1H2G1B4

References