Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2063986..2064563 Replicon chromosome
Accession NZ_CP013341
Organism Nitrosomonas ureae strain Nm10

Toxin (Protein)


Gene name vapC Uniprot ID A0A1H2FS26
Locus tag ATY38_RS09440 Protein ID WP_062559077.1
Coordinates 2063986..2064360 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0S3AJU3
Locus tag ATY38_RS09445 Protein ID WP_062559078.1
Coordinates 2064369..2064563 (-) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ATY38_RS09430 2059908..2060717 + 810 WP_062559075.1 NYN domain-containing protein -
ATY38_RS09435 2060733..2063993 - 3261 WP_062559076.1 type I restriction endonuclease subunit R -
ATY38_RS09440 2063986..2064360 - 375 WP_062559077.1 type II toxin-antitoxin system VapC family toxin Toxin
ATY38_RS09445 2064369..2064563 - 195 WP_062559078.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
ATY38_RS09450 2064642..2065082 - 441 WP_201011885.1 hypothetical protein -
ATY38_RS09455 2065175..2066173 - 999 WP_062559079.1 virulence protein RhuM/Fic/DOC family protein -
ATY38_RS09460 2066213..2067433 - 1221 WP_062559080.1 restriction endonuclease subunit S -
ATY38_RS09465 2067430..2069079 - 1650 WP_062559081.1 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2060733..2069795 9062


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-109)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-44)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13642.69 Da        Isoelectric Point: 6.6962

>T58479 WP_062559077.1 NZ_CP013341:c2064360-2063986 [Nitrosomonas ureae]
MILVDTSVWINHLRNNDPHLVRLLTGNSVLGHPFVRGELALGHLRQREAILAALDNLPQAPIAFADEVNVFIEQHALFGL
GIGLIDAHLLASTRLSGNTRLWTQDERLLAAALRLNLAASVHHD

Download         Length: 375 bp

>T58479 NZ_CP013341:c2064360-2063986 [Nitrosomonas ureae]
ATGATTCTGGTCGACACCTCGGTTTGGATTAACCATCTGCGCAATAACGATCCGCATTTAGTCCGCCTGCTGACCGGGAA
CAGCGTATTAGGTCACCCCTTTGTTCGTGGCGAACTGGCGCTGGGCCATTTGCGCCAGCGTGAAGCCATTCTGGCCGCAC
TGGATAACCTGCCCCAAGCCCCCATTGCGTTTGCCGATGAAGTGAATGTTTTCATCGAGCAACATGCGCTATTTGGTTTA
GGCATCGGATTGATCGACGCGCATTTGTTGGCTTCCACACGGTTATCCGGCAATACCCGGCTGTGGACACAGGATGAGCG
GCTTCTGGCAGCCGCGTTACGTCTTAATTTGGCAGCATCAGTTCACCATGACTAA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7110.16 Da        Isoelectric Point: 7.0129

>AT58479 WP_062559078.1 NZ_CP013341:c2064563-2064369 [Nitrosomonas ureae]
MRTTIVLDDELLEKAQALTHVQEKSALVKEALKALIERESAKRLANLGGSEPQLNAIPRRQTSE

Download         Length: 195 bp

>AT58479 NZ_CP013341:c2064563-2064369 [Nitrosomonas ureae]
ATGAGAACCACCATCGTATTGGATGACGAATTACTGGAAAAAGCGCAAGCCTTGACCCATGTGCAAGAGAAATCCGCATT
GGTCAAAGAAGCCTTGAAAGCGCTGATCGAACGGGAAAGCGCCAAAAGGCTGGCCAATTTGGGCGGCTCTGAGCCACAGC
TGAATGCTATCCCTCGCCGACAAACCAGCGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H2FS26

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3AJU3

References